A system and method for reducing a number of cancerous cells in the body through use of a treatment package a mixture of scintillating organic silicon-based polymer and a nitric oxide (NO) release agent at least partially surrounded by a functional material that facilitates consumption of the treatment package by a macrophage. The macrophage travels to the tumor and is then radiated with X-ray radiation causing the scintillating polymer to emit photons at a first wavelength which strike and causing the release agent to release substance toxic to the cancer cells. The scintillating polymer may comprise polydimethylsiloxane. The release agents may comprise one or more of the following: iron, copper, CrONO, Ruthenium (phen)(NO)(Cl), and Roussin's black salt. The scintillating polymer is selected such that the emitted photon wavelength corresponds to a wavelength of maximum absorption by the release agent.

• 출원번호 : 18893773
• 출원인 : Tinsley, James R.
• 특허번호 :
• IPC : A61K-033/00(2006.01);A61K-009/50(2006.01);A61K-031/80(2006.01);A61K-035/15(2025.01);A61K-041/00(2020.01);

Compounds, compositions and methods are provided for the inhibition of ENPP1. Aspects of the subject methods include contacting a sample with an ENPP1 inhibitor compound to inhibit the cGAMP hydrolysis activity of ENPP1. In some cases, the ENPP1 inhibitor compound is cell impermeable. ENPP1 inhibitor compounds can act extracellularly to block the degradation of cGAMP. Also provided are pharmaceutical compositions and methods for treating cancer. Aspects of the methods include administering to a subject a therapeutically effective amount of an ENPP1 inhibitor to treat the subject for cancer. In certain cases, the cancer is a solid tumor cancer. Also provided are methods of administering radiation therapy to a subject in conjunction with administering an ENPP1 inhibitor to the subject. The radiation therapy can be administered in the subject methods at a dosage and/or frequency effective to reduce radiation damage to the subject, but still instigate an immune response.

• 출원번호 : 18893468
• 출원인 : Li, Lingyin
• 특허번호 :
• IPC : C07F-009/6512(2006.01);A61K-031/44(2006.01);A61K-031/4706(2006.01);A61K-031/517(2006.01);A61K-031/675(2006.01);A61K-031/69(2006.01);A61K-045/06(2006.01);A61P-035/00(2006.01);C07D-215/46(2006.01);C07D-401/04(2006.01);C07F-005/02(2006.01);C07F-009/60(2006.01);C07F-009/6558(2006.01);

Multifunctional cerium oxide-P7C3 (aminopropyl carbazole) chimeric nanocompositions and methods for using these nanocompositions for enhancing bone deposition are provided. For example, these nanocompositions can be used to combat radiation-induced bone tissue/cell damage, to treat any disorders that promote osteoporosis, and/or to treat bone trauma/injury.

• 출원번호 : 18892448
• 출원인 : University of Central Florida Research Foundation, Inc.
• 특허번호 :
• IPC : A61K-047/69(2017.01);A61K-047/55(2017.01);A61P-019/10(2006.01);A61P-043/00(2006.01);

The present invention describes methods and techniques to improve scintigraphic images obtained by using nuclear medicine techniques for diagnostic analysis. The present invention describes a method and technique to up-sample and down-sample nuclear medicine images that models photon counts and noise characteristics of an image at its target resolution.

• 출원번호 : IB2024/059190
• 출원인 : JUBILANT DRAXIMAGE INC.;OTTAWA HOSPITAL RESEARCH INSTITUTE;
• 특허번호 :
• IPC : G01T-001/164(2006.01);G06T-003/4007(2024.01);G06T-005/00(2024.01);G06T-005/70(2024.01);

PROBLEM TO BE SOLVED: To provide a new pseudo-polymorph of the hemisuccinate of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridine-2-yl]-benzamide.SOLUTION: Provided is a pharmaceutical composition used for treating migraine in a mammal, containing a composition that contains (a) a dihydrate crystalline form (Form D) of the hemisuccinate of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridine-2-yl]-benzamide characterized by an X-ray diffraction containing a specific peak when using Cu-Kα radiation, (b) an anhydrous solid crystalline form (Form A) of the hemisuccinate of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridine-2-yl]-benzamide characterized by an X-ray diffraction containing a specific peak when using Cu-Kα radiation, and (c) a pharmaceutically acceptable carrier.SELECTED DRAWING: Figure 1A

• 출원번호 : 2024163884
• 출원인 : COLUCID PHARMACEUTICALS INC
• 특허번호 :
• IPC : A61K-031/4545(2006.01);A61P-025/06(2006.01);A61P-043/00(2006.01);

Mobile three-dimensional (3D) cadmium-zinc-telluride (CZT) radiation imager with aperture masks provide improved imaging speed and visual depth imaging capabilities, making the disclosed solutions suitable at least for intraoperative medical applications. A 3D CZT imager includes a plurality of CZT crystals configured to generate charge in response to incident radiation emitted from a radiated area within a portion of the anatomical body and one or more electrodes configured to collect the charge generated from the incident radiation and induce electrical signals in response to the collected charge. The 3D CZT imager further includes an aperture mask positioned between the plurality of CZT crystals and the radiation source/target being imaged. The mask includes openings being designed or configured for particular projections of a radiation distribution onto the plurality of CZT crystals. Solutions disclosed herein can generate localized 3D radiation image reconstructions in real-time or near real-time.

• 출원번호 : US2024/047647
• 출원인 : M3D, INC.
• 특허번호 :
• IPC : A61B-006/00(2024.01);G01T-001/202(2006.01);G01T-001/24(2006.01);

The invention describes a sensor device for testing a flat data carrier, in particular a value document, having an OSL security feature, which data carrier is transported through a detection region of the sensor device, in a specified transport direction at a specified transport speed in a measuring plane of the sensor device, with: a charging radiation source for charging the OSL security feature at a first wavelength, which is designed to emit charging radiation of a first wavelength onto a charging region in the detection region; a read-out radiation source for reading out the OSL security feature, which is designed to emit read-out radiation of a second wavelength, which differs from the first wavelength, onto a read-out region in the detection region; a detection device for detecting signal radiation, of a third wavelength which differs from the first and second wavelength, emitted from the OSL security feature when illuminated by the read-out radiation, said signal radiation being incident along a detection beam axis, wherein the sensor device is configured such that a region on the data carrier transported through the detection region in the measurement plane in the specified transport direction is first irradiated by the charging radiation and then by the read-out radiation.

• 출원번호 : DE2024/100829
• 출원인 : GIESECKE+DEVRIENT CURRENCY TECHNOLOGY GMBH
• 특허번호 :
• IPC : G07D-007/1205(2016.01);G07D-007/121(2016.01);G07D-007/202(2016.01);

An apparatus including an integrated system, which can include a nuclear reactor; and a containment isolation system configured to prevent release of radioactive material from the nuclear reactor. The containment isolation system can include a containment vessel and a containment isolation test valve. The containment isolation test valve can include a body having a first test port and a first test port plug. The containment isolation test valve can include a cover configured to couple with the body, the cover having, a first seal, a second seal, an area between the first seal and the second seal, a second test port, and a second test port plug. The containment isolation system can include a containment isolation valve.

• 출원번호 : US2024/047711
• 출원인 : NUSCALE POWER, LLC
• 특허번호 :
• IPC : G21C-017/00(2006.01);G21C-013/10(2006.01);G21C-009/00(2006.01);

A device and method for removing a rolled joint insert are provided. The device comprising: a body extending axially from a first end to a second end; a carriage coupled to the first end. The carriage is configured to extend or retract the body into or out of a lattice site of the fuel channel assembly. The device also comprises a tool head having a distal end and a proximate end, the proximate end is coupled to the second end of the body, and the distal end has a surface configured to push an end of a pressure tube in a nuclear fuel channel to expose the rolled joint. The tool head comprises: a heater for heating the rolled joint insert; a removal member for removing the rolled joint; and at least one centering member for centering the tool head in the lattice site.

• 출원번호 : CA2024/051253
• 출원인 : CANDU ENERGY INC.
• 특허번호 :
• IPC : G21C-019/20(2006.01);G21C-017/017(2006.01);

PROBLEM TO BE SOLVED: To provide a technique advantageous for acquiring signals from a plurality of regions of interest at high speed in AEC.SOLUTION: A radiography apparatus includes: a plurality of pixels; a plurality of drive circuits to which a plurality of row signal lines are connected to drive the plurality of pixels line by line; and a control unit. The control unit supplies a selection signal to a drive circuit group composed of two or more drive circuits, among a plurality of drive circuits, that drive detection pixels, in order to set, prior to irradiation, two or more detection pixels for measuring the dose of radiation incident from a plurality of pixels during irradiation. The control unit causes each of the drive circuits included in the drive circuit group to select a row signal line to which the detection pixel is connected from a plurality of row signal lines, and supplies a drive signal for driving a pixel connected to the row signal line selected from a plurality of row signal lines to each drive circuit included in the drive circuit group during irradiation, thereby acquiring a signal for measuring the dose of radiation incident from each of the detection pixels.SELECTED DRAWING: Figure 1

• 출원번호 : 2024164101
• 출원인 : CANON INC
• 특허번호 :
• IPC : A61B-006/42(2024.01);A61B-006/00(2024.01);