The present invention relates to an alpha spectrometry scanner for measuring one or more characteristics of radiation particles received from a radioactive sample under test, which sample is comprised in a radiopharmaceutical, said scanner comprising: detector means comprising a pixelated detector comprising a two dimensional array of detector pixels sensitive to said radiation particles received from said sample; a readout circuit in electric communication with said detector means, arranged to readout each pixel of said array, and wherein said readout circuit is arranged to generate, based on said readout of each of said detector pixels, a charge pattern for each hit of a radiation particle on said detector means, said charge pattern comprising spatial data, temporal data and energy deposited for each detector pixel of said array; spectroscopic analyser means in electric communication with said readout circuit to receive each charge pattern generated by said readout circuit, wherein said spectroscopic analyser means are arranged with a selective algorithm to extract features from said charge pattern and to identify and quantify a corresponding alpha particle of said sample based on said extracted features; a collimator arranged for selecting radiation particles that are on a path from said radioactive sample under test, towards said detector means, wherein said collimator is positioned in front of said detector means, and is comprised of an alpha particle vacuum collimator or an alpha particle air-flush collimator, said vacuum collimator or air-flush collimator is arranged to restrict the passage of said radiation particles and select particles on the path towards the pixels of the array of the pixelated detector.

• 출원번호 : NL2024/050347
• 출원인 : TECHNISCHE UNIVERSITEIT DELFT;ERASMUS UNIVERSITY MEDICAL CENTER ROTTERDAM;
• 특허번호 :
• IPC : G01T-001/29(2006.01);G01T-001/24(2006.01);G01T-001/36(2006.01);

A radiation treatment observation system has a camera configured to image Cherenkov light emissions in multiple spectral bands including a band having a center wavelength between 750 and 900 nanometers from a treatment zone to generate Cherenkov images, and an image processor. The image processor determines Cherenkov spectral correction parameters at pixels of the Cherenkov images based on differences between imaged intensity of Cherenkov light in the spectral bands at pixels of the Cherenkov images, and determines a corrected dosage map of the subject based upon at least the Cherenkov images and the Cherenkov spectral correction parameters. A method of monitoring radiation treatment of diffuse media includes determining surface coloration; determining subsurface optical parameters; and using the surface color and optical parameters, determining dose correction functions. The method includes obtaining and totalizing color Cherenkov images, and using the dose correction function to give corrected dose images.

• 출원번호 : US2024/035968
• 출원인 : THE TRUSTEES OF DARTMOUTH COLLEGE
• 특허번호 :
• IPC : A61N-005/10(2006.01);G01T-001/22(2006.01);G01T-001/36(2006.01);G02F-001/37(2006.01);A61B-006/42(2024.01);A61B-006/58(2024.01);A61N-005/06(2006.01);

Provided is a method for photochemical labeling comprising steps of delivering a photoreactive probe to a sample, and the photoreactive probe of formula (I): T─L─W, wherein the T portion is biotin or another biotin-based moiety; the L portion includes a chemical bond or a linker; and the W portion is a photoreactive moiety, wherein the photoreactive moiety can absorb UV light and become active to crosslink with an amino acid; and selectively illuminating the sample with optical radiation to activate the photoreactive moiety of the photoreactive probe in the selected region of interest; and forming a non-specific crosslinking between the photoreactive moiety of the probe and a plurality of amino acids of different proteins of the sample in the selected region of interest.

• 출원번호 : US2024/036001
• 출원인 : SYNCELL (TAIWAN) INC.;LIAO, Jung-Chi;
• 특허번호 :
• IPC :

The disclosure relates to a disinfection module for placement in, or in the proximity of, a heat exchanger unit, the disinfection module comprising at least one disinfection source, the at least one disinfection source configured to emit an electromagnetic radiation; an attachment plate for attachment to a portion of the heat exchanger unit; and at least one disinfection source receiver configured to receive the at least one disinfection source; the at least one disinfection source receiver comprises a first portion extending from the attachment plate, and a second portion for receiving the at least one disinfection source; wherein the second portion is removably attached to the first portion and protrudes from the first portion at an angle, the second portion orientated in a manner such that the at least one disinfection source emit the electromagnetic radiation toward a surface of the heat exchanger unit.

• 출원번호 : SG2024/050429
• 출원인 : OPULENT ELECTRONICS INTERNATIONAL PTE. LTD.
• 특허번호 :
• IPC : A61L-009/20(2006.01);F24F-008/22(2021.01);A61L-009/18(2006.01);

The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to Trop-2 or CEACAM5 and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 16 mg/kg, preferably 4, 6, 8, 9, 10, 12, or 16 mg/kg. When administered at specified dosages and schedules, the immunoconjugate can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Surprisingly, the immunoconjugate is effective to treat cancers that are refractory to or relapsed from irinotecan.

• 출원번호 : 18759723
• 출원인 : Goldenberg, David M.
• 특허번호 :
• IPC : A61K-031/454(2006.01);A61K-031/337(2006.01);A61K-031/4184(2006.01);A61K-031/4375(2006.01);A61K-031/4745(2006.01);A61K-031/513(2006.01);A61K-031/675(2006.01);A61K-031/7068(2006.01);A61K-031/7088(2006.01);A61K-031/713(2006.01);A61K-039/00(2006.01);A61K-039/395(2006.01);A61K-041/00(2006.01);A61K-045/06(2006.01);A61K-047/68(2006.01);A61K-051/10(2006.01);A61N-005/10(2006.01);C07K-016/28(2006.01);C07K-016/30(2006.01);

Arrangements and devices for reducing and/or preventing wear of a thermal sleeve in a nuclear reactor are disclosed. Arrangements include a first structure provided on or in one the thermal sleeve and a second structure provided on or in the head penetration adapter. At least a portion of the first structure and at least another portion of the second structure interact to resist, reduce, and/or prevent rotation of the thermal sleeve about its central axis relative to the head penetration adapter. Devices include a base for coupling to a guide tube of the reactor and a plurality of protruding members extending upward from the base. Each member having a portion for engaging a corresponding portion of a guide funnel of the thermal sleeve.

• 출원번호 : 18758967
• 출원인 : Westinghouse Electric Company LLC
• 특허번호 :
• IPC : G21C-013/036(2006.01);G21C-013/04(2006.01);

A transfer structure includes a circuit board that includes a first metal layer, a second metal layer, and a dielectric layer. The dielectric layer is located between the first metal layer and the second metal layer. The first metal layer includes a radiation portion and a microstrip that is coupled to one end of the radiation portion. The second metal layer is grounded. The radiation portion is provided with an opening to enable the radiation portion to form at least two resonance frequencies such that the operating bandwidth of the transfer structure can be extended.

• 출원번호 : 18758864
• 출원인 : He, Yin
• 특허번호 :
• IPC : H01Q-009/04(2006.01);G01S-007/03(2006.01);H01Q-001/48(2006.01);H01Q-013/06(2006.01);

Radiofrequency system includes a main antenna and a radiation pattern adaptation device including a printed circuit, on which two radiating strands and a reflector are printed, and on which a switching circuit is mounted, connected to the two radiating strands and arranged to be controlled, such that when the switching circuit is in a blocked mode, the radiofrequency system has a first radiation pattern; and when the switching circuit is in a passing mode, the two radiating strands form a halfwave dipole antenna, the radiofrequency system thus having a second radiation pattern having an increased or decreased gain in at least one predetermined direction.

• 출원번호 : 18758913
• 출원인 : KARTOUT, Madani
• 특허번호 :
• IPC : H01Q-009/28(2006.01);H01Q-003/24(2006.01);

The present invention concerns cucurbituril derivatives for radiolabeling, processes of production and uses thereof. Said invention also concerns the corresponding radiolabeled cucurbituril derivatives of formula (I), processes of production and uses thereof to obtain conjugates by supramolecular chemistry, in particular with targeting agents, more particularly labelled biomolecules, notably in nuclear medicine.

• 출원번호 : EP2024/068337
• 출원인 : UNIVERSITÉDE BOURGOGNE;CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE;
• 특허번호 :
• IPC : C07D-487/00(2006.01);C07B-059/00(2006.01);A61K-031/395(2006.01);A61P-035/00(2006.01);

The invention relates to a device and a method for a combined disinfection of surfaces and interior air in the public health sector. The disinfection device (1) according to the invention comprises a device for generating UV-C radiation (2), said device emitting radiation directly into the surrounding area, as well as a device for generating ozone (3) and is characterized in that the disinfection device (1) is designed to convey room air along the device for generating UV-C radiation (2) and/or the device for generating ozone (3) by means of at least one outlet (9). The method according to the invention for operating a disinfection device (1) is characterized in that during the operation of the device for generating UV-C radiation (2) and/or during the operation of the device for generating ozone (3), room air is conveyed along same through outlets (9).

• 출원번호 : IB2024/056342
• 출원인 : DINIES TECHNOLOGIES GMBH
• 특허번호 :
• IPC : A61L-002/20(2006.01);A61L-002/24(2006.01);A61L-009/015(2006.01);