Method of manufacturing semiconductor device includes forming photoresist layer over substrate. Forming photoresist layer includes combining first precursor and second precursor in vapor state to form photoresist material, wherein first precursor is organometallic having formula: MaRbXc, where M at least one of Sn, Bi, Sb, In, Te, Ti, Zr, Hf, V, Co, Mo, W, Al, Ga, Si, Ge, P, As, Y, La, Ce, Lu; R is substituted or unsubstituted alkyl, alkenyl, carboxylate group; X is halide or sulfonate group; and 1≤a≤2, b≥1, c≥1, and b+c≤5. Second precursor is at least one of an amine, a borane, a phosphine. Forming photoresist layer includes depositing photoresist material over the substrate. The photoresist layer is selectively exposed to actinic radiation to form latent pattern, and the latent pattern is developed by applying developer to selectively exposed photoresist layer to form pattern.

• 출원번호 : 18790000
• 출원인 : Taiwan Semiconductor Manufacturing Company, Ltd.
• 특허번호 :
• IPC : G03F-007/16(2006.01);G03F-007/11(2006.01);G03F-007/20(2006.01);H01L-021/027(2006.01);

Some aspects of this disclosure provide strategies, systems, reagents, methods, and kits that are useful for the targeted editing of nucleic acids, including editing a single site within the genome of a cell or subject, e.g., within the human genome. The disclosure provides fusion proteins of nucleic acid programmable DNA binding proteins (napDNAbp), e.g., Cas9 or variants thereof, and nucleic acid editing proteins such as cytidine deaminase domains (e.g., novel cytidine deaminases generated by ancestral sequence reconstruction), and adenosine deaminases that deaminate adenine in DNA. Aspects of the disclosure relate to fusion proteins (e.g., base editors) that have improved expression and/or localize efficiently to the nucleus. In some embodiments, base editors are codon optimized for expression in mammalian cells. In some embodiments, base editors include multiple nuclear localization sequences (e.g., bipartite NLSs), e.g., at least two NLSs. In some embodiments, methods for targeted nucleic acid editing are provided.

• 출원번호 : 18791223
• 출원인 : The Broad Institute, Inc.
• 특허번호 :
• IPC : C07K-014/47(2006.01);C12N-009/22(2006.01);C12N-009/78(2006.01);

A device that produces control data for a laser device for surgical correction of vision produces control data such that the laser emits the laser radiation to isolate a volume in the cornea. The device calculates radius of curvature RCV* to determine the control data, the cornea reduced by the volume having the radius of curvature RCV* and the radius of curvature being site-specific and satisfying the equation: RCV*(r,φ)=1/((1/RCV(r,φ))+BCOR(r,φ)/(nC−1))+F, wherein RCV(r,φ) is the local radius of curvature of the cornea before the volume is removed, nC is the refractive index of the material of the cornea, F is a coefficient, and BCOR(r,φ) is the local change in refraction required for the desired correction of vision in a plane lying in the vertex of the cornea, and at least two radii r1 and r2 satisfy the equation BCOR(r=r1,φ)≠BCOR(r=r2,φ).

• 출원번호 : 18789935
• 출원인 : Stobrawa, Gregor
• 특허번호 :
• IPC : A61F-009/008(2006.01)

In an example method of forming a waveguide part having a predetermined shape, a photocurable material is dispensed into a space between a first mold portion and a second mold portion opposite the first mold portion. A relative separation between a surface of the first mold portion with respect to a surface of the second mold portion opposing the surface of the first mold portion is adjusted to fill the space between the first and second mold portions. The photocurable material in the space is irradiated with radiation suitable for photocuring the photocurable material to form a cured waveguide film so that different portions of the cured waveguide film have different rigidity. The cured waveguide film is separated from the first and second mold portions. The waveguide part is singulated from the cured waveguide film. The waveguide part corresponds to portions of the cured waveguide film having a higher rigidity than other portions of the cured waveguide film.

• 출원번호 : 18790541
• 출원인 : Bhagat, Sharad D.
• 특허번호 :
• IPC : B29D-011/00(2006.01);B29C-035/08(2006.01);B29C-039/26(2006.01);B29L-011/00(2006.01);

A lithography system for extreme ultraviolet (EUV) radiation includes a housing (25) with an interior (24) containing a residual gas (27), and at least one gas-binding component (29) which is arranged in the interior (24) and has a gas-binding material for binding contaminating substances (28). The gas-binding component (29) has at least one flow duct (33) having at least one surface with the gas-binding material, with a gas flow of the residual gas (27) in the flow duct (33) having a Knudsen number of between 0.01 and 5, preferably between 0.01 and 0.5, in particular between 0.01 and 0.3, and with a casing (26) which encapsulates a beam path of the EUV lithography system (1) being arranged in the interior (24) of the housing (25). The casing (26) preferably has an opening (37) with a maintenance shaft (36) in which the gas-binding component (29) is arranged.

• 출원번호 : 18790520
• 출원인 : KRUITHOF, Wilbert
• 특허번호 :
• IPC : G03F-007/00(2006.01)

The present disclosure relates to a pharmaceutical composition comprising 177Lu-PSMA I&T and methods of administering the same. The administration of the composition results in a low absorbed radiation dose per gram of tissue in a human patient's body, including the kidneys, gastrointestinal tract, left colon, liver, rectum, red marrow, spleen, lacrimal glands, and salivary glands.

• 출원번호 : 18791256
• 출원인 : Jalomäki, Jarno
• 특허번호 :
• IPC : A61K-051/04(2006.01)

The present disclosure relates to a pharmaceutical composition comprising 177Lu-PSMA I&T and methods of administering the same. The administration of the composition results in a low absorbed radiation dose per gram of tissue in a human patient's body, including the kidneys, gastrointestinal tract, left colon, liver, rectum, red marrow, spleen, lacrimal glands, and salivary glands.

• 출원번호 : 18791270
• 출원인 : Jalomäki, Jarno
• 특허번호 :
• IPC : A61K-051/04(2006.01);A61P-035/00(2006.01);

A computer-implemented method of image reconstruction can comprise acquiring projection data of a region of a patient. The projection data comprising one or more projections representing measured ray intensities of attenuated rays of radiation emitted from a radiation source, passed through the patient, and detected at a detector. The detector and the radiation source are rotated about an isocentre. The method can further comprise performing opposing projection data correction to obtain modified projection data. The opposing projection data correction comprising modification of the measured ray intensities for projection data acquired at substantially 180 degrees offsets about the isocentre. The method can further comprise running an image reconstruction process on the modified projection data to obtain an image of the region of the patient.

• 출원번호 : 18790412
• 출원인 : Mason, Jonathan Hugh
• 특허번호 :
• IPC : G06T-011/00(2006.01);G06T-005/73(2006.01);

The present disclosure relates to a pharmaceutical composition comprising Lu-PSMA I&T and methods of administering the same. The administration of the composition results in a low absorbed radiation dose per gram of tissue in a human patient's body, including the kidneys, gastrointestinal tract, left colon, liver, rectum, red marrow, spleen, lacrimal glands, and salivary glands.

• 출원번호 : US2024/040449
• 출원인 : CURIUM US LLC
• 특허번호 :
• IPC : A61K-051/08(2006.01);A61P-013/08(2006.01);A61K-006/50(2020.01);

The invention relates to an arrangement (1) for non-invasively characterising cerebrospinal fluid and other bodily fluids, • comprising a sensor head (7) for emitting terahertz radiation (T) and receiving its reflections (R), which sensor head, during use, is applied to the patient (3) in such a way that the terahertz radiation (T) radiates into the bodily fluid, • comprising an electronic evaluation circuit for calculating measurement data from the emitted and received radiation (T, R), wherein this circuit automatically determines the extinction of different wavelengths and, from this, calculates the concentration of different substances in the bodily fluid, • and comprising a display (8) for optically representing the data calculated by the evaluation circuit as results.

• 출원번호 : EP2024/071758
• 출원인 : LALA, Helin;LALA, Sultan;
• 특허번호 :
• IPC : G01N-021/3581(2014.01);A61B-005/00(2006.01);A61B-005/0507(2021.01);A61B-005/145(2006.01);