Disclosed is a system and method for the controlled clustering of gene regulatory proteins at the specific target genomic loci. The technology enables formation of liquid-like droplets closely interfaced with genome organization. This technology can be utilized for perturbing endogenous nuclear structures as well as nucleating synthetic membrane-less assemblies. The technology can also be utilized for inducing or detecting mechanical stresses within the genome.

• 출원번호 : 18754912
• 출원인 : The Trustees of Princeton University
• 특허번호 :
• IPC : C12N-015/90(2006.01);C07K-014/47(2006.01);C12N-009/22(2006.01);

A mutant TDP-43 protein, having a deletion of a nuclear localization signal sequence in the amino acid sequence of a wild-type TDP-43 protein, and also having any one of the following mutations (a) to (c) or a combination of these mutations: (a) a mutation, in which the 147th and 149th phenylalanines are substituted with leucines,(b) a mutation, in which the 194th phenylalanine is substituted with leucine, and(c) a mutation, in which the 229th and 231st phenylalanines are substituted with leucines.

• 출원번호 : 18754639
• 출원인 : TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE
• 특허번호 :
• IPC : C07K-014/47(2006.01);A61K-049/00(2006.01);G01N-033/50(2006.01);

The present invention efficiently performs analysis regarding the amount of an analyte and analysis regarding an element. An analysis device (100) comprises a radiation source, a detector (5), and an analysis unit (6). The radiation source irradiates particulate matter (FP) with radiation. The detector (5) detects transmitted radiation passing through the particulate matter (FP) and a fluorescent X-ray generated through the irradiation of the particulate matter (FP) with radiation. The analysis unit (6) performs analysis regarding the amount of the particulate matter (FP) on the basis of the transmitted radiation detected by the detector (5), and performs analysis regarding an element contained in the particulate matter (FP) on the basis of the fluorescent X-ray detected by the detector (5).

• 출원번호 : JP2024/023176
• 출원인 : HORIBA, LTD.
• 특허번호 :
• IPC : G01N-023/2206(2018.01);G01N-001/02(2006.01);G01N-023/02(2006.01);G01N-023/223(2006.01);

A sanitisation apparatus (1) for vehicles, in particular buses or coaches, comprising at least one radiating body (2) and activation means (3) associable with the radiating body (2) to allow and/or prohibit a radiation emission. Furthermore, the apparatus (1) comprises detection means (4) adapted to detect at least one operating parameter of the sanitisation apparatus (1) and/or of the vehicle and generate at least one detection signal (SR) representative of the at least one operating parameter. In particular, the apparatus (1) comprises a control unit (5) configured to receive the detection signal (SR), generate a command signal (SC) as a function of the contents of the detection signal (SR) and/or as a function of at least one preset operating parameter and to send the command signal (SC) to the activation means (3) to perform sanitisation at least as a function of the contents of the detection signal (SR) and/or of the at least one preset operating parameter.

• 출원번호 : IB2024/056218
• 출원인 : AZIENDA TRASPORTI VERONA S.R.L. - ATV S.R.L.
• 특허번호 :
• IPC : A61L-002/10(2006.01);A61L-002/24(2006.01);B25J-001/00(2006.01);B60S-003/00(2006.01);B62D-047/00(2006.01);

A radiation-activatable compound, a drug conjugate thereof and the use thereof, and the use of the compound as a drug conjugate linking group.

• 출원번호 : CN2024/101253
• 출원인 : PEKING UNIVERSITY
• 특허번호 :
• IPC : C07D-405/12(2006.01);C07D-217/12(2006.01);C07D-213/02(2006.01);A61K-047/54(2017.01);A61K-049/00(2006.01);A61K-041/00(2020.01);A61P-035/00(2006.01);

A solid electrolyte material is composed of Li, M, and X. M is at least one selected from the group consisting of metal elements other than Li and metalloids. X is at least one selected from the group consisting of F, Cl, Br, and I. FWHM/2θp≤0.015 is satisfied, wherein FWHM represents a half width of an X-ray diffraction peak in an X-ray diffraction pattern obtained by performing X-ray diffraction measurement on the solid electrolyte material by using Cu—Kα radiation, the X-ray diffraction peak having the highest intensity within a range of diffraction angles 2θ greater than or equal to 25° and less than or equal to 35°, and 2θp represents a diffraction angle at a center of the X-ray diffraction peak.

• 출원번호 : 18753861
• 출원인 : NAGAMINE, Kenta
• 특허번호 :
• IPC : H01M-010/0562(2006.01);C01F-017/36(2006.01);H01M-004/62(2006.01);H01M-010/0525(2006.01);

An antenna device comprises a dielectric substrate, an antenna including a radiation plate and a ground conductor plate, a connector, and cover member. A position of a feeding point on the radiation plate is different to a position of a centroid of the radiation plate in front view of the antenna, and the antenna and the cover member cover a periphery of the connector when the antenna, the connector, and the cover member are viewed along a direction orthogonal to a first straight line connecting the centroid to the feeding point and orthogonal to a thickness direction of the dielectric substrate.

• 출원번호 : 18754136
• 출원인 : AGC Inc.
• 특허번호 :
• IPC : H01Q-001/32(2006.01);H01Q-001/12(2006.01);H01Q-001/48(2006.01);H01Q-009/04(2006.01);

A device and method of use for the calibration of a detector. The calibration device includes a first source configured to produce first electromagnetic energy EMR. A first diffuser is connected to the first source and is configured to accept the first EMR and provide a first diffused portion of the first EMR. An integrating sphere defines an interior and is optically connected to the first diffuser, and is configured to accept the first diffused portion from the first diffuser into the interior. An exit port connected to the integrating sphere is configured to pass at least a portion of electromagnetic energy. A thermal mechanism is configured to adjust and maintain the temperature of at least the first source. The integrating sphere is configured to pass only a second portion of the first diffused portion of the first EMR from the first diffuser to the exit port. In another embodiment, the calibration device has an arm, an actuator, and a module. The module supports at least a first source that emits electromagnetic energy, a thermal mechanism, and a controller. The actuator is configured to move the arm and module to a calibration position enabling the first source to be within the line of sight of an external detector, while the controller is configured to control the thermal mechanism enabling precise temperature regulation of the source and therefore the regulation of the emitted electromagnetic energy. When the device is not in the calibration position, the actuator is configured to move the arm and module to a stowed position, protecting the device from ambient electromagnetic radiation and harm.

• 출원번호 : 18753768
• 출원인 : FUCILE, Paul Dominic
• 특허번호 :
• IPC : G01S-019/23(2006.01);G01J-005/08(2006.01);G01J-005/80(2006.01);G01S-017/50(2006.01);G01S-019/26(2006.01);

A high-energy x-ray camera with radiation-hardened fiber optic faceplate to protect its sensor chip from radiation damage, a field-replaceable scintillator which degrades under radiation. A signal and SNR monitoring system and method to optimize the scintillator replacement schedule.

• 출원번호 : 18752791
• 출원인 : Wilcox, Randall Arthur
• 특허번호 :
• IPC : G01T-001/24(2006.01);G01T-001/20(2006.01);

The present invention provides methods for recovering metals, including rare earth metals, from mixed metals. An example is the recovery of metals from electronic waste. The method of separation is based on the inversion and/or lowering of the thermodynamic energy barrier by using one or more stressors applied at appropriate ratios to create lower energy points in the thermodynamic energy landscape of the mixed metals. Example stressors include a) a chemical stress, b) a mechanical stress, c) a thermal stress, d) and electromagnetic radiation and/or light stress, an interfacial stress, and/or a magnetic flux gradient stress.

• 출원번호 : 18752936
• 출원인 : Thuo, Martin
• 특허번호 :
• IPC : C22B-059/00(2006.01);C22B-003/02(2006.01);C22B-003/20(2006.01);C22B-003/32(2006.01);C22B-004/04(2006.01);C22B-007/00(2006.01);C22B-011/00(2006.01);C22B-034/24(2006.01);C22B-058/00(2006.01);