Embodiments are directed to a method of treating acute radiation syndrome comprising administering to a subject following exposure to radiation a PIF peptide. Some embodiments describe a method of treating acute radiation syndrome following radiation exposure comprising transplanting bone marrow that has been exposed to a PIF peptide prior to transplantation into a subject. Other embodiments describe a method of increasing engraftment of a transplanted organ, tissue, or cell by pre-exposing the organ, tissue, or cell to a PIF peptide.

• 출원번호 : 18731133
• 출원인 : Barnea, Eytan R.
• 특허번호 :
• IPC : A61K-038/10(2006.01);A61K-009/00(2006.01);A61K-038/07(2006.01);A61K-038/08(2006.01);A61K-039/00(2006.01);C12N-005/0789(2006.01);

A device for processing a workpiece using a laser beam of a laser includes a retarder plate and a focusing device. The retarder plate is configured to apply a first location-dependent phase retardation to a first part of the laser beam having a first input polarization, and to apply a second location-dependent phase retardation to a second part of the laser beam having a second input polarization. The focusing device is configured to focus the laser beam in at least one focus zone. A beam form of the laser beam in the focus zone is determined by the first location-dependent phase retardation and the second location-dependent phase retardation. The at least one focus zone at least partially overlaps with the workpiece. The workpiece is subjected to laser radiation in the at least one focus zone and is thus processed.

• 출원번호 : 18679672
• 출원인 : Flamm, Daniel
• 특허번호 :
• IPC : B23K-026/064(2006.01);B23K-026/067(2006.01);B23K-026/38(2006.01);B23K-026/70(2006.01);

Disclosed are sunscreen compositions comprising avobenzone, octocrylene, octisalate, and aluminum starch octenylsuccinate. Also disclosed is a method for protecting skin from ultraviolet radiation, the method comprising topically applying to the skin a composition comprising an effective amount of avobenzone, octocrylene, octisalate, and aluminum starch octenylsuccinate.

• 출원번호 : US2024/031897
• 출원인 : MARY KAY INC.
• 특허번호 :
• IPC : A61Q-017/04(2006.01);A61Q-019/00(2006.01);A61K-008/06(2006.01);A61K-008/30(2006.01);A61K-008/04(2006.01);A61K-008/02(2006.01);

Provided is an antenna device capable of achieving radiation directivity of a wide angle by using a single patch antenna, without incurring enlargement of the device or complication of a configuration thereof due to array formation.　An antenna device 1 configured by using a dielectric substrate comprises: a patch antenna 20 that is formed in a prescribed conductor layer; a cavity 12 that has a shape surrounding the patch antenna 20 in a plan view as viewed from a Z direction which is the thickness direction of the dielectric substrate, and that is formed in a dielectric layer 11 disposed above the prescribed conductor layer; and ground conductors 21, 22, 23 that are arranged to face the dielectric layer 11, with the prescribed conductor layer interposed therebetween in the Z direction.

• 출원번호 : JP2024/019948
• 출원인 : NITERRA CO., LTD.
• 특허번호 :
• IPC : H01Q-013/08(2006.01)

In some aspects, the present disclosure provides a catheter system for use with radiation therapy. The catheter can include a core that is formed from a radioprotective material. The core may extend from a proximal end to a distal end along a longitudinal axis. The catheter system further includes a sleeve formed from a biocompatible material that extends about the core along the longitudinal axis. The sleeve may have an outer wall that is configured to extend through a biological lumen of a patient. The sleeve and the core are configured to cooperate to reduce a radiation dose received by tissue or organs in the patient that are proximate to the catheter system. The core may absorb or scatter radiation incident upon the radioprotective material, and the sleeve may absorb at least some of the radiation scattered by the core.

• 출원번호 : US2024/031698
• 출원인 : THE BRIGHAM AND WOMEN’S HOSPITAL, INC.;
• 특허번호 :
• IPC : A61M-025/16(2006.01);A61L-029/02(2006.01);A61L-029/04(2006.01);A61L-029/12(2006.01);A61M-025/10(2013.01);

Water-soluble nanoclusters that include gold, and a bisTV-heterocyclic carbene ligand that includes at least one water soluble moiety are described. The water soluble moiety comprises a polyether, a carboxylic acid, a carboxylate, an ammonium group, a sugar, or a protein. The water soluble moiety is located on the wingtips of the bisNHC ligands or the water soluble moiety is located on the backbone of the bisNHC ligands. The nanocluster may further comprise a targeting ligand such as a derivative of folic acid, or the metal nanocluster may further comprise at least one clickable group such as an azide. As described herein, the water-soluble Atir, nanoclustcrs protected by NHC ligands have been synthesized and characterized. Their water solubility properties aid in biomedical testing and application of this material. Applications for the nanoclusters include photosensitizing and cell imaging due to the properties of luminescence when exposed to radiation.

• 출원번호 : CA2024/050729
• 출원인 : QUEEN'S UNIVERSITY AT KINGSTON;NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM;
• 특허번호 :
• IPC : C07D-235/04(2006.01);A61K-041/00(2020.01);A61K-049/00(2006.01);A61P-035/00(2006.01);B01J-019/08(2006.01);C07D-403/10(2006.01);C07D-519/00(2006.01);C07H-015/26(2006.01);C07K-016/00(2006.01);C07K-016/28(2006.01);C09K-011/06(2006.01);C12M-001/34(2006.01);G01D-005/26(2006.01);G01N-021/62(2006.01);G01N-024/08(2006.01);G01R-033/28(2006.01);H10K-030/35(2023.01);H10K-030/50(2023.01);

Disclosed herein are 6-thiopurine containing dimer compounds of formula I: or a pharmaceutically acceptable salt, ester, prodrug, hydrate, or tautomer thereof, wherein both Rs are concurrently H, or (PO), and both Rs are concurrently H or OH. Methods for preparing the compounds of formula I from the corresponding 6-thiopurine containing monomer compounds are also disclosed. Also disclosed are methods for converting the dimer compounds of Formula I to the corresponding 6-thiopurine containing monomer compounds. The compounds are useful for treating, ameliorating, or preventing various types of cancer, particularly those that are drug resistant. The compounds of Formula I can also be used in conjunction with a checkpoint inhibitor and/or radiation in different ways for treating various types of cancer.

• 출원번호 : US2024/031754
• 출원인 : MAIA BIOTECHNOLOGY, INC.
• 특허번호 :
• IPC : C07H-019/173(2006.01);C07H-019/19(2006.01);C07H-019/20(2006.01);A61P-035/00(2006.01);A61K-031/7076(2006.01);

The present disclosure provides compounds of formula I, II, or III or pharmaceutically acceptable salts thereof, wherein R-R, R-R, R, R, and R are defined herein. Also provided are compositions comprising the compounds, methods of using the compounds for delivering radiation to dihydrofolate reductase (DHFR) expressing cells or tissues, killing a cell or tissue comprising dihydrofolate reductase (eDHFR), or treating a cancer in a subject in need thereof.

• 출원번호 : US2024/031640
• 출원인 : THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
• 특허번호 :
• IPC :

A method and apparatus for calculating the electric arc radiation energy of an electric power switch device, and a device. The method comprises: constructing a two-dimensional electric arc simulation model for an electric power switch device according to a fundamental equation of two-dimensional magnetohydrodynamics; performing iterative calculation in the two-dimensional electric arc simulation model according to the initial temperature and initial pressure of the electric power switch device, so as to obtain temperature data that meets iterative constraint conditions; and according to the temperature data and the electric arc radius of the electric power switch device, calculating the electric arc radiation energy of the electric power switch device. Radiation calculations of different regions of an electric arc are taken into consideration, such that a calculated radiation energy result has a high accuracy and a rational physical mechanism, the existing need to solve a radiation transport equation is avoided, the radiation calculation time is greatly reduced, the calculation efficiency is improved, and the method is more suitable for simulation calculation of electric arcs in the field of electric power industry. The technical problem of the results of electric arc calculations of existing circuit breakers obtained by means of using existing radiation transport equations being inaccurate due to the dependency of radiation of the circuit breakers on space and spectra is solved.

• 출원번호 : CN2024/096269
• 출원인 : ELECTRIC POWER RESEARCH INSTITUTE, CHINA SOUTHERN POWER GRID
• 특허번호 :
• IPC : G06F-030/28(2020.01);G06F-111/04(2020.01);G06F-113/08(2020.01);G06F-119/14(2020.01);G06F-119/08(2020.01);

A system for and method of measuring one or more spectral properties such as wavelength and/or bandwidth of a beam of deep ultraviolet excimer laser radiation in which an absolute reference is used to calibrate instrumentation for measuring the one or more spectral properties, the absolute reference being generated using Doppler free spectroscopy. Also disclose are systems and methods in which an isotopically concentrated material is used.

• 출원번호 : IB2024/055270
• 출원인 : CYMER, LLC
• 특허번호 :
• IPC : G03F-007/00(2006.01);H01S-003/13(2006.01);