All 3,257,929 Page 56/325,793
-
2025
- Book : ()
- Pub. Date : 2025
- Page : pp.1-1
- Keyword :
-
2025
Delays in cancer treatment are detrimental across nearly every disease site in oncology including head and neck cancer. This study aimed to evaluate the impact of same-day access for patients with newly diagnosed head and neck cancer referred for radiation therapy consultation. From March 2021 to March 2023, a total of 50 consecutive patients who completed curative treatment were matched to a control subject who did not use the same-day initiative based on age, gender, histology, performance status, primary tumor site, stage, p16 status, treatment, and smoking history. With a median follow up of 30 months, there were no differences in 3-year overall survival, progression-free survival, or local-regional control between the 2 cohorts ( P > .05, for all). However, the same-day access initiative was associated with significant reductions in time from diagnosis to first day of radiation (49 days vs 71 days, P < .001); time from diagnosis to completion of diagnostic work-up (32 days vs 43 days, P = .01); and time from diagnosis to completion of all treatment (91 days vs 111 days, P < .001).The same-day access initiative was associated with significant reductions in time from diagnosis to first day of radiation (49 days vs 71 days, P < .001); time from diagnosis to completion of diagnostic work-up (32 days vs 43 days, P = .01); and time from diagnosis to completion of all treatment (91 days vs 111 days, P < .001). The same-day access initiative thus enhanced multidisciplinary coordination and expedited treatment for patients with head and neck cancer. - Book : 12()
- Pub. Date : 2025
- Page :
- Keyword :
-
2025
Objective: In this study our main goal is to evaluate the impact of Covid-19 on the mental health among the medical students at Dhaka city. Method: This cross-sectional study was carried out at Tertiary Medical college and hospital from July 2020 to May 2021. A total of 100 who were the Medical college students in Dhaka participated in the survey. The survey targeted active (current) students. Results: During the study, majority of the study group belong to 18 to 24 years and 52% were female. 80% were from nuclear family members, 28% cases economic condition were middle, 60% cases didn’t do any physical exercise and 35% cases sleep patterns were changed. Most of the study group had suffer mid-level of symptoms (depression; 45%, anxiety; 40% and stress; 42%). Followed by extreme severe cases were noted in depression; 8%, anxiety; 12% and stress; 13%. Conclusion: Our results, can help to detect mental health problems and those at high risk and treatment. Future longitudinal research is needed for closer studying and translating this knowledge to enhance student health correlations between mental illness and COVID–19 variables. As many students spend time on the Internet (including social media) during the quarantine, online counseling, campaigns and other awareness efforts are useful for reducing the impact of COVID-19 in the population on mental health.- Book : 13(01)
- Pub. Date : 2025
- Page : pp.204-207
- Keyword :
-
2025
Quantification of the temporal sequence of molecular behavior in live individual cells holds promise for improving causal and mechanistic models of cell biology. In recent years, different methods for inferring molecular labeling from microscopy data have been developed, especially in the context of “virtual pathology”, but less effort has been directed to the context of single-cell dynamics and live-cell imaging. We demonstrate that phase-contrast live-cell imaging of MCF10A cells, without labeling data, is predictive of dynamical, single-cell behavior of the cell-cycle reporter Human DNA Helicase B (HDHB) – in particular, of the nuclear vs. cytoplasmic localization of this fluorescent reporter of cyclin-dependent kinase activity. Prediction quality improves substantially when temporal sequences of images are combined in a “delay embedding” framework. When different featurizations of the imaging data are examined, we find that features derived from a variational auto-encoder (VAE) outperform “classical” image features derived from shape and texture. We find the best performance, with PearsonR∼0.9 on test data, using VAE features augmented by categorical predictions, all within the delay-embedding framework – in comparison toR ∼0.5 based on “ordinary” regression with VAE features.- Book : ()
- Pub. Date : 2025
- Page :
- Keyword :
-
2025
- Book : ()
- Pub. Date : 2025
- Page :
- Keyword :
-
2025
- Book : ()
- Pub. Date : 2025
- Page :
- Keyword :
-
2025
Dark matter may exist today in the form of ultraheavy composite bound states. Collisions between such dark matter states can release intense bursts of radiation that include γ-rays among the final products. Thus, indirect detection signals of dark matter may include unconventional γ-ray bursts. Such bursts may have been missed not necessarily because of their low arriving γ-ray fluxes, but rather their briefness and rareness. We point out that intense bursts whose nondetection thus far are due to the latter can be detected in the near future with existing and planned facilities. In particular, we propose that, with slight experimental adjustments and suitable data analyses, imaging atmospheric Cherenkov telescopes (IACTs) and Pulsed All-Sky Near-Infrared and Optical Search for Extra-Terrestrial Intelligence (PANOSETI) are promising tools for detecting such rare, brief, but intense bursts. We also show that, if we assume these bursts originate from collisions of dark matter states, IACTs and PANOSETI can probe a large dark matter parameter space beyond existing limits. Additionally, we present a concrete model of dark matter that produces bursts potentially detectable in these instruments.
Published by the American Physical Society
2025
- Book : 111(2)
- Pub. Date : 2025
- Page :
- Keyword :
-
2025
La cuestión nuclear de Corea del Norte, que sigue sin resolverse desde la primera crisis nuclear, surgió en 1994. A pesar de que se han hecho esfuerzos para resolver la crisis, hasta ahora el impasse nuclear no se ha resuelto totalmente. El estudio busca demostrar que cualquier uso de la fuerza en Corea del Norte traería riesgos políticos, militares y en el derecho internacional, razones por las cuales ha sido descartada como opción para Estados Unidos.
La importancia de este estudio consiste en evidenciar que el uso de la fuerza en Corea del Norte tiene límites, dadas las implicaciones y riesgos de esta política, especialmente para Estados Unidos, Corea del Sur, Japón, China y Rusia. La metodología es de índole cualitativa porque recurre a descripciones y análisis del objeto de estudio. Este trabajo se divide en cinco partes: en la primera se discutirá la diferencia entre Preemption y Prevención. En la segunda, las implicaciones militares que cualquier eventual uso de la fuerza en la RPC tendría para los vecinos de Estados Unidos y Corea del Norte. En la tercera parte, se considerarán los riesgos políticos del uso de la fuerza En la cuarta sección se discutirán las implicaciones para el derecho internacional, y en la sección final se expondrán las conclusiones.- Book : (18)
- Pub. Date : 2025
- Page : pp.1-23
- Keyword :
-
2025
- Book : ()
- Pub. Date : 2025
- Page :
- Keyword :
-
2025
Thermoelectric effects in p–n junctions are widely used for energy generation with thermal gradients, creation of compact Peltier refrigerators and, most recently, for sensitive detection of infrared and terahertz radiation. It is conventionally assumed that electrons and holes creating thermoelectric current are in equilibrium and share the common quasi-Fermi level. We show that lack of interband equilibrium results in an anomalous sign and magnitude of thermoelectric voltage developed across the p–n junction. The anomalies appear provided the diffusion length of minority carriers exceeds the size of hot spot at the junction. Normal magnitude of thermoelectric voltage is partly restored if interband tunneling at the junction is allowed. The predicted effects can be relevant to the cryogenically cooled photodetectors based on bilayer graphene and mercury cadmium telluride quantum wells.- Book : ()
- Pub. Date : 2025
- Page :
- Keyword :
