An imaging system comprising a light source configured to radiate a biological sample, wherein the light source is optimized for rapid imaging of the biological sample using a photoelectric effect. The system also includes a sample holder configured to secure the biological sample during imaging. The system also includes a stage assembly to which the sample holder is mounted, where stage assembly moves the biological sample during imaging. The system further includes a detector configured to receive electrons emitted from the biological sample in response to radiation from the light source.

• 출원번호 : US2024/031542
• 출원인 : THE UNIVERSITY OF CHICAGO;THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS;
• 특허번호 :
• IPC :

In one aspect, a method of imaging a biological specimen is disclosed, which includes defining a plurality of reference location points across a surface of the biological specimen, directing ablating radiation to the biological specimen at a first plurality of sample locations corresponding to a first subset of the defined reference location points to ablate at least a portion of the specimen at each of said locations, thereby generating a gas phase sample from each of said sample locations, ionizing each of the gas phase samples to generate ions corresponding to that gas phase sample, acquiring one or more mass signals corresponding to ions associated with each of the ablated portions, and identifying at least one region of interest based on analysis of the mass signals. An image of the identified region of interest can be acquiring using image mass cytometry.

• 출원번호 : IB2024/055307
• 출원인 : STANDARD BIOTOOLS CANADA INC.
• 특허번호 :
• IPC : H01J-049/26(2006.01);G02B-021/36(2006.01);

Water-soluble nanoclusters that include gold, and a bisTV-heterocyclic carbene ligand that includes at least one water soluble moiety are described. The water soluble moiety comprises a polyether, a carboxylic acid, a carboxylate, an ammonium group, a sugar, or a protein. The water soluble moiety is located on the wingtips of the bisNHC ligands or the water soluble moiety is located on the backbone of the bisNHC ligands. The nanocluster may further comprise a targeting ligand such as a derivative of folic acid, or the metal nanocluster may further comprise at least one clickable group such as an azide. As described herein, the water-soluble Atir, nanoclustcrs protected by NHC ligands have been synthesized and characterized. Their water solubility properties aid in biomedical testing and application of this material. Applications for the nanoclusters include photosensitizing and cell imaging due to the properties of luminescence when exposed to radiation.

• 출원번호 : CA2024/050729
• 출원인 : QUEEN'S UNIVERSITY AT KINGSTON;NATIONAL UNIVERSITY CORPORATION TOKAI NATIONAL HIGHER EDUCATION AND RESEARCH SYSTEM;
• 특허번호 :
• IPC : C07D-235/04(2006.01);A61K-041/00(2020.01);A61K-049/00(2006.01);A61P-035/00(2006.01);B01J-019/08(2006.01);C07D-403/10(2006.01);C07D-519/00(2006.01);C07H-015/26(2006.01);C07K-016/00(2006.01);C07K-016/28(2006.01);C09K-011/06(2006.01);C12M-001/34(2006.01);G01D-005/26(2006.01);G01N-021/62(2006.01);G01N-024/08(2006.01);G01R-033/28(2006.01);H10K-030/35(2023.01);H10K-030/50(2023.01);

The present disclosure provides compounds of formula I, II, or III or pharmaceutically acceptable salts thereof, wherein R-R, R-R, R, R, and R are defined herein. Also provided are compositions comprising the compounds, methods of using the compounds for delivering radiation to dihydrofolate reductase (DHFR) expressing cells or tissues, killing a cell or tissue comprising dihydrofolate reductase (eDHFR), or treating a cancer in a subject in need thereof.

• 출원번호 : US2024/031640
• 출원인 : THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA
• 특허번호 :
• IPC :

Provided is an antenna device capable of achieving radiation directivity of a wide angle by using a single patch antenna, without incurring enlargement of the device or complication of a configuration thereof due to array formation.　An antenna device 1 configured by using a dielectric substrate comprises: a patch antenna 20 that is formed in a prescribed conductor layer; a cavity 12 that has a shape surrounding the patch antenna 20 in a plan view as viewed from a Z direction which is the thickness direction of the dielectric substrate, and that is formed in a dielectric layer 11 disposed above the prescribed conductor layer; and ground conductors 21, 22, 23 that are arranged to face the dielectric layer 11, with the prescribed conductor layer interposed therebetween in the Z direction.

• 출원번호 : JP2024/019948
• 출원인 : NITERRA CO., LTD.
• 특허번호 :
• IPC : H01Q-013/08(2006.01)

In some aspects, the present disclosure provides a catheter system for use with radiation therapy. The catheter can include a core that is formed from a radioprotective material. The core may extend from a proximal end to a distal end along a longitudinal axis. The catheter system further includes a sleeve formed from a biocompatible material that extends about the core along the longitudinal axis. The sleeve may have an outer wall that is configured to extend through a biological lumen of a patient. The sleeve and the core are configured to cooperate to reduce a radiation dose received by tissue or organs in the patient that are proximate to the catheter system. The core may absorb or scatter radiation incident upon the radioprotective material, and the sleeve may absorb at least some of the radiation scattered by the core.

• 출원번호 : US2024/031698
• 출원인 : THE BRIGHAM AND WOMEN’S HOSPITAL, INC.;
• 특허번호 :
• IPC : A61M-025/16(2006.01);A61L-029/02(2006.01);A61L-029/04(2006.01);A61L-029/12(2006.01);A61M-025/10(2013.01);

Disclosed herein are 6-thiopurine containing dimer compounds of formula I: or a pharmaceutically acceptable salt, ester, prodrug, hydrate, or tautomer thereof, wherein both Rs are concurrently H, or (PO), and both Rs are concurrently H or OH. Methods for preparing the compounds of formula I from the corresponding 6-thiopurine containing monomer compounds are also disclosed. Also disclosed are methods for converting the dimer compounds of Formula I to the corresponding 6-thiopurine containing monomer compounds. The compounds are useful for treating, ameliorating, or preventing various types of cancer, particularly those that are drug resistant. The compounds of Formula I can also be used in conjunction with a checkpoint inhibitor and/or radiation in different ways for treating various types of cancer.

• 출원번호 : US2024/031754
• 출원인 : MAIA BIOTECHNOLOGY, INC.
• 특허번호 :
• IPC : C07H-019/173(2006.01);C07H-019/19(2006.01);C07H-019/20(2006.01);A61P-035/00(2006.01);A61K-031/7076(2006.01);

시스템이 기판 상의 광경화성 조성물을 가열하기 위한 제1 가열 수단; 700 nm 미만의 파장으로 화학 방사선을 방출하도록 구성된 화학 방사선 소스; 및 광경화성 조성물이 화학 방사선 소스에 의해 노출될 때 광경화성 조성물의 광경화 온도를 달성하기 위해 제1 가열 수단에 의해 생성될 목표 온도를 결정하도록 구성된 제어기를 포함할 수 있으며, 광경화 온도는 주위 온도보다 높다.방법이 기판 상에 광경화성 조성물을 분배하는 단계; 경화된 층을 형성하기 위해 광경화성 조성물의 층을 주위 온도보다 높은 광경화 온도에서 광경화시키는 단계; 및 베이킹된 층을 형성하기 위해 경화된 층을 베이킹하는 단계를 포함할 수 있다.시스템 및 방법은 층의 두께 변화가 0% 또는 0%에 더 근접하게 할 수 있다.

• 출원번호 : 10-2024-0069842
• 출원인 : 캐논 가부시끼가이샤
• 특허번호 :
• IPC : G03F-007/00;H01L-021/3105;H01L-021/67;

A tile for heat insulation has a body forming an enclosure. The body can be aluminum or aluminum alloy material. Inside the enclosure one or more panels of reflective material are disposed and divide the enclosure into two or more separate sub-chambers. The tile inhibits conduction, convection and radiation heat transfer therethrough. The tile can be a rectangular box (e.g., have planar surfaces) for insulating a home or building, or can be curved with a C-shape to allow the tile to conform to a curved surface, such as a vessel (e.g., tank, pipe) having a circular perimeter, or can have an S-shape to provide a roof tile.

• 출원번호 : US2024/031442
• 출원인 : IDEALAB STUDIO, LLC
• 특허번호 :
• IPC : E04D-001/06(2006.01);E04B-001/80(2006.01);E04D-011/02(2006.01);

Provided is a LiDAR system for a vehicle capable of optimizing light distribution of a laser beam irradiating an irradiation area, while simplifying the structure of an irradiation-side optical system. A lens 58 of an irradiation device 12 of a LiDAR system 10 has a reflection surface 69n of a conical side surface in which a vertex T68n is on a light source 33n side and a center axis (auxiliary line C68n) is deviated with respect to an optical axis (auxiliary line C33n) of a light source 33n, and reflects a laser beam from the light source 33n in a radiation direction on a reflection surface 69n.

• 출원번호 : JP2024/019775
• 출원인 : STANLEY ELECTRIC CO., LTD.
• 특허번호 :
• IPC : G01S-007/481(2006.01);G01S-017/931(2020.01);