Provided is a method for photochemical labeling comprising steps of delivering a photoreactive probe to a sample, and the photoreactive probe of formula (I): T─L─W, wherein the T portion is biotin or another biotin-based moiety; the L portion includes a chemical bond or a linker; and the W portion is a photoreactive moiety, wherein the photoreactive moiety can absorb UV light and become active to crosslink with an amino acid; and selectively illuminating the sample with optical radiation to activate the photoreactive moiety of the photoreactive probe in the selected region of interest; and forming a non-specific crosslinking between the photoreactive moiety of the probe and a plurality of amino acids of different proteins of the sample in the selected region of interest.

• 출원번호 : US2024/036001
• 출원인 : SYNCELL (TAIWAN) INC.;LIAO, Jung-Chi;
• 특허번호 :
• IPC :

A radiation treatment observation system has a camera configured to image Cherenkov light emissions in multiple spectral bands including a band having a center wavelength between 750 and 900 nanometers from a treatment zone to generate Cherenkov images, and an image processor. The image processor determines Cherenkov spectral correction parameters at pixels of the Cherenkov images based on differences between imaged intensity of Cherenkov light in the spectral bands at pixels of the Cherenkov images, and determines a corrected dosage map of the subject based upon at least the Cherenkov images and the Cherenkov spectral correction parameters. A method of monitoring radiation treatment of diffuse media includes determining surface coloration; determining subsurface optical parameters; and using the surface color and optical parameters, determining dose correction functions. The method includes obtaining and totalizing color Cherenkov images, and using the dose correction function to give corrected dose images.

• 출원번호 : US2024/035968
• 출원인 : THE TRUSTEES OF DARTMOUTH COLLEGE
• 특허번호 :
• IPC : A61N-005/10(2006.01);G01T-001/22(2006.01);G01T-001/36(2006.01);G02F-001/37(2006.01);A61B-006/42(2024.01);A61B-006/58(2024.01);A61N-005/06(2006.01);

The disclosure relates to a disinfection module for placement in, or in the proximity of, a heat exchanger unit, the disinfection module comprising at least one disinfection source, the at least one disinfection source configured to emit an electromagnetic radiation; an attachment plate for attachment to a portion of the heat exchanger unit; and at least one disinfection source receiver configured to receive the at least one disinfection source; the at least one disinfection source receiver comprises a first portion extending from the attachment plate, and a second portion for receiving the at least one disinfection source; wherein the second portion is removably attached to the first portion and protrudes from the first portion at an angle, the second portion orientated in a manner such that the at least one disinfection source emit the electromagnetic radiation toward a surface of the heat exchanger unit.

• 출원번호 : SG2024/050429
• 출원인 : OPULENT ELECTRONICS INTERNATIONAL PTE. LTD.
• 특허번호 :
• IPC : A61L-009/20(2006.01);F24F-008/22(2021.01);A61L-009/18(2006.01);

The invention relates to a method for depositing a thermochromic vanadium dioxide layer on a glass substrate (101) inside a processing chamber, wherein a) the glass substrate (101) is guided past a coating device (103) inside the working chamber; b) oxygen is introduced into the working chamber through at least one inlet (106); c) the glass substrate (101) is heated by means of at least one heating device (105) prior to the layer deposition; d) a target made of vanadium or vanadium oxide is sputtered by means of at least one magnetron inside the coating device (103); e) after the layer deposition, light radiation, which is visible to the human eye, is emitted by means of at least one illumination device (108) positioned on one side of the glass substrate (101); a first actual value for the transmission of the light radiation is detected by means of a first sensor (109) on the other side of the glass substrate (101); the first actual value for the transmission is compared inside an evaluation device with a first setpoint value for the transmission and, depending on said first comparison result, the oxygen flow through the at least one inlet (106) into the working chamber is regulated, and wherein f) after the layer deposition but before reaching the first sensor (109), a second actual value for the temperature of the glass substrate (101) is detected by means of a second sensor (110), is compared with a second setpoint value inside the evaluation device, and the oxygen flow through the at least one inlet (106) into the working chamber is regulated depending on the second comparison result.

• 출원번호 : EP2024/068329
• 출원인 : FRAUNHOFER-GESELLSCHAFT ZUR FÖRDERUNG DER ANGEWANDTEN FORSCHUNG E.V.;
• 특허번호 :
• IPC : C23C-014/00(2006.01);C03C-017/00(2006.01);C23C-014/08(2006.01);

The present invention relates to therapeutic immunoconjugates comprising SN-38 attached to an antibody or antigen-binding antibody fragment. The antibody may bind to Trop-2 or CEACAM5 and the immunoconjugate may be administered at a dosage of between 4 mg/kg and 16 mg/kg, preferably 4, 6, 8, 9, 10, 12, or 16 mg/kg. When administered at specified dosages and schedules, the immunoconjugate can reduce solid tumors in size, reduce or eliminate metastases and is effective to treat cancers resistant to standard therapies, such as radiation therapy, chemotherapy or immunotherapy. Surprisingly, the immunoconjugate is effective to treat cancers that are refractory to or relapsed from irinotecan.

• 출원번호 : 18759723
• 출원인 : Goldenberg, David M.
• 특허번호 :
• IPC : A61K-031/454(2006.01);A61K-031/337(2006.01);A61K-031/4184(2006.01);A61K-031/4375(2006.01);A61K-031/4745(2006.01);A61K-031/513(2006.01);A61K-031/675(2006.01);A61K-031/7068(2006.01);A61K-031/7088(2006.01);A61K-031/713(2006.01);A61K-039/00(2006.01);A61K-039/395(2006.01);A61K-041/00(2006.01);A61K-045/06(2006.01);A61K-047/68(2006.01);A61K-051/10(2006.01);A61N-005/10(2006.01);C07K-016/28(2006.01);C07K-016/30(2006.01);

The present invention relates to a radiation-curable ink composition. The present invention further relates to a method for preparing a radiation-curable ink composition. In addition, the present invention relates to a method for applying an image onto a recording medium.

• 출원번호 : 24185071.8
• 출원인 : Canon Production Printing Holding B.V.
• 특허번호 :
• IPC : C09D-011/101(2014.01);C09D-011/34(2014.01);C09D-011/12(2006.01);C09D-011/38(2014.01);

Disclosed herein is a radiotherapy system comprising: a radiation delivery system for delivering radiation to a target region of a patient; a computer data store configured to store a current radiotherapy treatment plan, the current radiotherapy treatment plan comprising a plurality of control points, each control point defining a value of at least one radiation delivery variable; a delivery control module configured to retrieve the current radiotherapy treatment plan and control the radiation delivery system to deliver radiation to the target region based on the current radiotherapy treatment plan; and a plan adaptation module.

• 출원번호 : EP2024/068125
• 출원인 : ELEKTA LIMITED
• 특허번호 :
• IPC : A61N-005/10(2006.01)

The present invention relates to methods of diagnosis and/or radiotherapy, comprising the administration of a compound of Formula (I) and aCu /Cu radioisotope to deliver a targeted dose of radiation for the diagnosis and treatment of a neuroendocrine cancer, particularly neuroblastoma in children.

• 출원번호 : AU2024/050685
• 출원인 : CLARITY PHARMACEUTICALS LIMITED
• 특허번호 :
• IPC : A61K-051/08(2006.01);A61K-009/08(2006.01);A61P-035/00(2006.01);

The present invention relates to a method for base editing of plant DNA, comprising expressing, in a plant, a plant cell or a protoplast of interest, a base editing composition comprising at least one DNA binding protein and at least one enzyme protein or comprising polynucleotides that encoding the proteins. The present invention is useful for editing bases of nuclear DNA or organellar DNA in plants and, in particular, is useful for editing bases of DNA of plant organelles such as chloroplasts or mitochondria. This base editing composition can be used in methods for causing, in plant DNA, targeted conversion of an adenine (A) base to guanine (G), targeted conversion of a cytosine (C) base to thymine (T) base, or both. In addition, the present invention relates to plant cells, plants or seeds in which this base editing is carried out.

• 출원번호 : KR2024/008974
• 출원인 : GREENGENE, INC.
• 특허번호 :
• IPC : C12N-015/82(2006.01);C12N-009/22(2006.01);C12N-009/78(2006.01);C07K-014/47(2006.01);A01H-005/10(2006.01);

Provided in the present application are a process module, a semiconductor process device and a thin film deposition method. The process module comprises a reaction module, a base used for bearing a wafer being arranged in the reaction module; a heating module in communication with the reaction module, a thermal radiation apparatus being arranged at the top of the heating module and used for radiating heat towards the interior of the heating module; and a conveying apparatus, which is arranged in the reaction module and used for bearing the wafer, and can convey the wafer between the reaction module and the heating module. The process module, the semiconductor process device and the thin film deposition method provided in the present application can improve the wafer heating efficiency and the wafer heating uniformity.

• 출원번호 : CN2024/101917
• 출원인 : BEIJING NAURA MICROELECTRONICS EQUIPMENT CO., LTD.
• 특허번호 :
• IPC : C23C-014/54(2006.01);C23C-014/56(2006.01);H01L-021/67(2006.01);H01L-021/677(2006.01);