Embodiments of the disclosure concern methods and compositions related to optimization and selection of cord blood units for production of immune cells, such as NK cells, for adoptive cell therapy use. In specific embodiments, particular characteristics of the cord blood units and/or characteristics of cells derived therefrom are analyzed. When a threshold measurement for one or more characteristics is met for the cord blood unit(s) and/or characteristics of cells derived therefrom, the cord blood unit(s) are utilized as a source for production of immune cells. Specific characteristics for measurement include, for example, cord blood cell viability, time from birth to cord blood unit cryopreservation, total nuclear cell recovery, baby weight, baby gender, mothers age, gestational age, CD34 positive cell percentage, and/or nucleated red blood cell content. Characteristics may be determined prior to and/or post-cryopreservation.
- 출원번호 : US2024/031821
- 출원인 : BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM
- 특허번호 :
- IPC :