Disclosed herein are compositions and methods for inhibiting collagen production mediated by the Fused in Sarcoma (FUS) ribonucleoprotein. As disclosed herein, the C terminal domain of FUS contains an uncommon nuclear localization sequence (NLS) motif called PY-NLS that binds the nuclear import receptor transportin. Phosphorylation of FUS leads to its association with transportin and nuclear translocation with consequent increased in collagen production. Therefore, disclosed herein is an isolated peptide having a transportin-binding moiety, which inhibits FUS from binding transportin, linked to a membrane translocating motif. These compositions and methods can be used to inhibit FUS-mediated collagen production, and treat fibrotic disease involving FUS-mediated collagen accumulation in kidneys and other organs displaying fibrotic diseases.

• 출원번호 : 18800870
• 출원인 : POZZI, Ambra A.
• 특허번호 :
• IPC : C07K-014/47(2006.01);A61K-038/17(2006.01);A61K-038/18(2006.01);A61K-045/06(2006.01);A61P-013/12(2006.01);C07K-014/50(2006.01);C07K-014/705(2006.01);

The present disclosure provides compositions and methods for use in treating radiation injury such as a radiation induced skin injury in a subject at risk of such injury. Also provided herein is a reproducible animal model of cutaneous radiation injuries for evaluation of medical countermeasures.

• 출원번호 : 18800237
• 출원인 : HAYNES, Carissa
• 특허번호 :
• IPC : A61K-038/17(2006.01);A61K-009/06(2006.01);A61K-047/38(2006.01);A61P-017/02(2006.01);

An MRI system includes a static magnetic field magnet configured to determine an MR frequency for imaging and generate a first static magnetic field be applied to an object during imaging; a pre-polarizing magnet configured to polarize nuclear spin of the object prior to imaging of the object and generate a second static magnetic field, application of which is stopped during imaging of the object; at least one first shield configured to block a leakage magnetic field of the first static magnetic field, the first shield being provided in a region opposite to an imaging region of the object with respect to the static magnetic field magnet; and at least one second shield configured to block a leakage magnetic field of the second static magnetic field, the second shield being provided in a region opposite to the imaging region with respect to the pre-polarizing magnet.

• 출원번호 : 18800203
• 출원인 : CANON MEDICAL SYSTEMS CORPORATION
• 특허번호 :
• IPC : G01R-033/421(2006.01);A61B-005/055(2006.01);G01R-033/34(2006.01);G01R-033/3875(2006.01);

The present invention provides a multi-degree-of-freedom conductor depositing system for tokamak toroidal field coil winding packs, belongs to the field of development of toroidal field superconducting coils for nuclear fusion. The multi-degree-of-freedom conductor depositing system is mounted on a winding table and distributed along the contour of the toroidal field coil. The optical proximity switches detect the position signals between the winding table and the bending unit and transmit them to an automatic control system. The multi-degree-of-freedom conductor depositing system is distributed in a spiral shape from the top to the bottom from the position of the bending unit along the direction of coil winding. The conductor is deposited onto the track drive mechanism of the multi-degree-of-freedom conductor depositing device, which has a bidirectional moving and rotating function. This avoids the risk of insulation rupture due to friction between the conductor and the depositing tooling during the coil winding process. It also has the advantages of simple structure, convenient operation and high reliability.

• 출원번호 : 18801230
• 출원인 : HE, Jian
• 특허번호 :
• IPC : H01F-041/06(2006.01);G21B-001/05(2006.01);

A non-contact material assessment system and method are provided. In embodiments, a system includes: a radiation source generating a pattern of diffracted elements; a detector configured to: capture a first image of a first diffracted element when a sample is in an initial state, and a second image when the sample is in a second state; and capture a first image of a second diffracted element when the sample is in the initial state, and a second image when the sample is in the second state; and a controller to: determine a displacement of the first diffracted element based on the first and second images of the first diffracted element; determine a displacement of the second diffracted element based on the first and second images of the second diffracted element; and determine a characteristic of the sample over based on the displacement of the first and second diffracted elements.

• 출원번호 : 18800684
• 출원인 : The Government of the United States of America, as represented by the Secretary of the Navy
• 특허번호 :
• IPC : G01N-003/06(2006.01);G01N-003/08(2006.01);

A system (100) for determining a gating window (110) for delivering a beam of therapeutic radiation to an anatomical region (130) undergoing cyclical motion, is provided. The system includes one or more processors (140) configured to determine, for each of one or more sets of at least one constraint (Dmax) imposed on the anatomical region, a maximum gating window (110) throughout which a position of the anatomical region (130) in a temporal sequence of images (1601..m) satisfies the set of at least one constraint, and a corresponding start (Ampstart, Pstart) and end (Ampend, Pend) of the gating window in the cycle.

• 출원번호 : EP2024/072716
• 출원인 : KONINKLIJKE PHILIPS N.V.
• 특허번호 :
• IPC : A61N-005/10(2006.01)

• 출원번호 : CN2024/111348
• 출원인 : SHANGHAI NUCLEAR ENGINEERING RESEARCH &DESIGN INSTITUTE CO., LTD.;
• 특허번호 :
• IPC : G21C-015/14(2006.01)

A 3D printing system includes a build vessel, a build platen, a projection light engine, a movement mechanism, and a controller. The build vessel is configured to contain a photocurable liquid. The build vessel includes a lower wall having an opening with an opening width along a lateral X-axis and a transparent sheet that closes the opening. The build platen has a a lower surface in facing relation with the transparent sheet. The build platen defines a platen width along a lateral X-axis that is greater than the opening width. The projection light engine is positioned below the build vessel. The projection light engine is configured to project pixelated radiation up to a build plane that is less than one millimeter above the transparent sheet.

• 출원번호 : 18800637
• 출원인 : Sivaprasad, Akarsh
• 특허번호 :
• IPC : B29C-064/255(2006.01);B29C-064/129(2006.01);B29C-064/236(2006.01);B29C-064/277(2006.01);B33Y-010/00(2006.01);B33Y-030/00(2006.01);

The present invention relates to a method for controlling a part strength control element assembly to enable turbine load-following, comprising the steps of: identifying operation driving characteristics of a part strength control element assembly according to turbine loads through simulation of power plant-simulation calculations with varying turbine load; determining a maximum insertion position within the core of the part strength control element assembly on the basis of the operation driving characteristics; deriving a target position of the part strength control element assembly according to turbine load on the basis of the maximum insertion position; and controlling the insertion position of the part strength control element assembly according to the target position.

• 출원번호 : KR2024/011952
• 출원인 : KOREA HYDRO &NUCLEAR POWER CO., LTD;
• 특허번호 :
• IPC : G21C-007/12(2006.01);G21D-003/00(2006.01);G21D-003/16(2006.01);G06F-030/20(2020.01);

The present invention relates to a method for producing a fired heavy-clay ceramics shaped body by optionally drying and firing using electromagnetic radiation at a frequency of 300 MHz (wavelength: approximately 1000 mmm) to 300 GHz (wavelength: approximately 1 mm), wherein the green shaped body is heated in at least one heating-up phase at an average temperature-change rate of at least 5 K/min.

• 출원번호 : EP2024/072724
• 출원인 : ERLUS AKTIENGESELLSCHAFT
• 특허번호 :
• IPC : C04B-033/30(2006.01);C04B-033/32(2006.01);C04B-033/34(2006.01);