The present invention aims to provide a medicament capable of treating and/or preventing diseases associated with oxidative stress by inhibiting the protein-protein interaction between Keap1 and Nrf2 and activating Nrf2. The present invention relates to a compound represented by the following formula (1): wherein each symbol is as described in the DESCRIPTION, or a pharmaceutically acceptable salt thereof. In addition, the present invention also relates to a medicament containing the aforementioned compound, for the prophylaxis and/or treatment of diseases involving oxidative stress selected from the group consisting of chronic kidney disease, non-alcoholic steatohepatitis, chronic obstructive pulmonary disease, radiation skin disorder, radiation mucosal disorder, cardiac failure, pulmonary arterial hypertension, Parkinson's disease, Friedreich's ataxia, multiple sclerosis, age-related macular degeneration, retinitis pigmentosa and glaucoma.
- 출원번호 : 18927756
- 출원인 : DAIICHI SANKYO COMPANY, LIMITED
- 특허번호 :
- IPC : C07D-515/04(2006.01);A61K-031/554(2006.01);C07D-417/10(2006.01);C07D-419/10(2006.01);C07D-419/14(2006.01);C07D-513/04(2006.01);C07D-515/20(2006.01);C07D-519/00(2006.01);