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2025
As the forefront of inland extension on the Indian plate, the northeastern Tibetan Plateau, marked by low strain rates and high stress levels, is one of the regions with the highest seismic risk. Analyzing seismicity through statistical methods holds significant scientific value for understanding tectonic conditions and assessing earthquake risk. However, seismic monitoring capacity in this region remains limited, and earthquake frequency is low, complicating efforts to improve earthquake catalogs through enhanced identification and localization techniques. Bi-scale empirical probability integral transformation (BEPIT), a statistical method, can address these data gaps by supplementing missing events shortly after moderate to large earthquakes, resulting in a more reliable statistical data set. In this study, we analyzed six earthquake sequences with magnitudes of MS ≥ 6.0 that occurred in northeastern Tibet since 2009, following the upgrade of the regional seismic network. Using BEPIT, we supplemented short-term missing aftershocks in these sequences, creating a more complete earthquake catalog. ETAS model parameters and b values for these sequences were then estimated using maximum likelihood methods to analyze parameter variability across sequences. The findings indicate that the b value is low, reflecting relatively high regional stress. The background seismicity rate is very low, with most mainshocks in these sequences being background events rather than foreshock-driven events. The p-parameter of the ETAS model is high, indicating that aftershocks decay relatively quickly, while the α-parameter is also elevated, suggesting that aftershocks are predominantly induced by the mainshock. These conditions suggest that earthquake prediction in this region is challenging through seismicity analysis alone, and alternative approaches integrating non-seismic data, such as electromagnetic and fluid monitoring, may offer more viable solutions. This study provides valuable insights into earthquake forecasting in the northeastern Tibetan Plateau.- Book : 27(2)
- Pub. Date : 2025
- Page : pp.174-174
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2025
- Book : ()
- Pub. Date : 2025
- Page : pp.1-19
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2025
This article examines the growing influence of Chinese investments in Latin America, focusing on Venezuela and Argentina. It explores how these countries benefit from Chinese capital and how this investment impacts their economies. Venezuela has relied on oil-backed loans to sustain its political system, worsening its economic challenges. In contrast, Argentina has channeled Chinese investment into infrastructure, including hydroelectric dams, nuclear plants, railway modernization, and energy diversification projects. The study highlights that while infrastructure investment can enhance economic stability and reduce reliance on further loans, both countries remain vulnerable due to their dependence on raw material exports. Despite these challenges, the study underscores that with institutional improvements and a shift toward diversification, such investments can contribute to sustainable growth in both nations. A qualitative research approach using secondary sources was employed to analyze the long-term implications of Chinese investments in these two economies.
- Book : 13(1)
- Pub. Date : 2025
- Page : pp.43-54
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2025
Abstract
We consider the nuclear absorption of dark matter as an alternative to the typical
indirect detection search channels of dark matter decay or annihilation. In this scenario, an
atomic nucleus transitions to an excited state by absorbing a pseudoscalar dark matter particle
and promptly emits a photon as it transitions back to its ground state. The nuclear excitation of
carbon and oxygen in the Galactic Center would produce a discrete photon spectrum in the
𝒪(10) MeV range that could be detected by gamma-ray telescopes. Using the
BIGSTICK large-scale shell-model code, we calculate the excitation energies of carbon and
oxygen. We constrain the dark matter-nucleus coupling for current COMPTEL data, and provide
projections for future experiments AMEGO-X, e-ASTROGAM, and GRAMS for dark matter masses from
∼ 10 to 30 MeV. We find the excitation process to be very sensitive to the dark matter mass
and find that the future experiments considered would improve constraints on the dark
matter-nucleus coupling within an order of magnitude.- Book : 2025(02)
- Pub. Date : 2025
- Page : pp.017-017
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2025
- Book : 1012()
- Pub. Date : 2025
- Page : pp.116821-116821
- Keyword :
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2025
The rapid development of nuclear medicine offers vast opportunities for diagnosing neoplasms, particularly in endocrinology. The use of the [11C]C-methionine radiotracer is currently limited due to its physical properties and the complex production process. However, studies conducted so far have demonstrated its utility in PET imaging, helping to detect lesions that often remain elusive with other modalities. This systematic review focuses on [11C]C-methionine in diagnosing hyperparathyroidism and pituitary tumors, highlighting its high effectiveness, which can be crucial in diagnosis. Despite some disadvantages, it should be considered when available, especially when other modalities or radiotracers fail.- Book : 18(2)
- Pub. Date : 2025
- Page : pp.229-229
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2025
ABSTRACT
Over the past two decades, significant progress has been made in understanding mechanotransduction to the nucleus. Nevertheless, most research has focused on outside-in signalling orchestrated by external mechanical stimuli. Emerging evidence highlights the importance of intrinsic nuclear mechanisms in the mechanoresponse. The discovery of actin and associated motor proteins, such as myosins, in the nucleus, along with advances in chromatin organisation research, has raised new questions about the contribution of intranuclear architecture and mechanics. Nuclear actin and myosins are present in various compartments of the nucleus, particularly at sites of DNA processing and modification. These proteins can function as hubs and scaffolds, cross-linking distant chromatin regions and thereby impacting local and global nuclear membrane shape. Importantly, nuclear myosins are force-sensitive and nuclear actin cooperates with mechanosensors, suggesting a multi-level contribution to nuclear mechanics. The crosstalk between nuclear myosins and actin has significant implications for cell mechanical plasticity and the prevention of pathological conditions. Here, we review the recent impactful findings that highlight the roles of nuclear actin and myosins in nuclear organisation. Additionally, we discuss potential links between these proteins and emphasize the importance of using new methodologies to unravel nuclear-derived regulatory mechanisms distinct from the cytoskeleton.- Book : 138(3)
- Pub. Date : 2025
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2025
- Book : ()
- Pub. Date : 2025
- Page : pp.100723-100723
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2025
Abstract
Constitutive androstane receptor (CAR) and pregnane X receptor (PXR) are closely related nuclear receptors with overlapping regulatory functions in xenobiotic clearance but distinct roles in endobiotic metabolism. Car activation has been demonstrated to ameliorate hypercholesterolemia by regulating cholesterol metabolism and bile acid elimination, whereas PXR activation is associated with hypercholesterolemia and liver steatosis. Here we show a human CAR agonist/PXR antagonist, MI-883, which effectively regulates genes related to xenobiotic metabolism and cholesterol/bile acid homeostasis by leveraging CAR and PXR interactions in gene regulation. Through comprehensive analyses utilizing lipidomics, bile acid metabolomics, and transcriptomics in humanized PXR-CAR-CYP3A4/3A7 mice fed high-fat and high-cholesterol diets, we demonstrate that MI-883 significantly reduces plasma cholesterol levels and enhances fecal bile acid excretion. This work paves the way for the development of ligands targeting multiple xenobiotic nuclear receptors. Such ligands hold the potential for precise modulation of liver metabolism, offering new therapeutic strategies for metabolic disorders.- Book : 16(1)
- Pub. Date : 2025
- Page :
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2025
Abstract
One of the specialized spectroscopic techniques used to analyze the interaction of a light field with a target atom or molecule is nonlinear four-wave mixing in the extreme ultraviolet (XUV) region. In this paper, we investigate the fundamental interaction of atomic argon and molecular nitrogen gases with a light field in the perturbative nonlinear regime by cascading high-order harmonic generation (HHG) radiation with a multi-color laser. We optimize the phase-matching of collinear, multiple-cycle laser pulses with incommensurate frequencies (800 nm, 1400 nm and 560 nm) in third-order nonlinear wave-mixing with HHG-XUV radiation. Using a single-gas-cell interaction chamber, we reveal the electron wave packet dynamics in atomic and molecular systems by examining the time-dependent spectral features of the wave-mixing field, including intensity and frequency modulation patterns. This simple experimental setup presents a novel spectroscopy technique that can provide deeper insights into target systems, and potentially more complex molecular gases, involving multi-electron interaction regimes.- Book : 27(2)
- Pub. Date : 2025
- Page : pp.023022-023022
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