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2025
Melanoma skin cancer is a global public health threat due to its increasing rates and the possibility of severe outcomes if not adequately addressed. Melanoma is caused by ultraviolet radiation and, among its two stages, malignant is more dangerous than benign. The diagnosis of melanoma is typically based on visual inspection and manual methods carried out by experienced physicians. However, this method is usually slow and has a high probability of error. Deep-learning-based models can offer better and low-cost treatments for people with melanoma. This study aimed to develop a deep-learning model to classify melanoma skin cancer in its early stages. This study presents a modified deep-learning model, named DeepMelaNet, to correctly classify skin cancer images as benign or malignant. The proposed classifier achieved an accuracy of 93.40%, a precision of 98%, a recall of 94%, and an F1 score of 93% on a dataset of 10,000 melanoma skin cancer images, offering a practical solution that can help healthcare professionals in early skin cancer prediction.- Book : 15(1)
- Pub. Date : 2025
- Page : pp.19627-19635
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2025
- Book : 15(7)
- Pub. Date : 2025
- Page : pp.2700-2719
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2025
AbstractOcean water clarity, influenced by marine chlorophyll concentration, significantly alters the distribution of shortwave radiation in the water column. This work aims to assess the effects of varying chlorophyll on the upper‐ocean physical properties and their subsequent impact on the atmosphere, using a coupled ocean‐atmosphere regional model for the Mediterranean and Black Seas. We performed 11‐year (2011–2021) twin‐simulation experiments based on different chlorophyll concentrations to estimate the penetration of solar radiation in the ocean. The first simulation used a monthly climatology field of chlorophyll concentrations derived from satellite observations, while in the second experiment, the chlorophyll concentration was kept constant at 0.05 , representing clear water conditions. Results show that radiative heating driven by chlorophyll amplifies the seasonal cycle of temperature in the upper layers, leading to increased surface warming in summer and surface cooling in winter. Also, higher surface chlorophyll contributes to cooling in subsurface layers throughout the year due to its shading effect. The temperature response to chlorophyll variations is controlled by the mixed layer depth and a balance between (a) direct near‐surface radiative heating due to the chlorophyll absorption and (b) indirect cooling resulting from vertical turbulent mixing processes with subsurface waters. The atmosphere moderates the seasonal sea surface temperature (SST) response caused by chlorophyll differential heating primarily through changes in latent heat flux. Ultimately, our simulations suggest that increased surface chlorophyll concentrations enhance the Mediterranean overturning circulation, highlighting the necessity of incorporating realistic optical forcing into regional climate modeling studies.- Book : 130(2)
- Pub. Date : 2025
- Page :
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2025
- Book : 29(4)
- Pub. Date : 2025
- Page :
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2025
This work aims to study the technical and economical feasibility of a new hydrogen transport network by 2035 in France. The goal is to furnish the charging stations for fuel cell electrical vehicles with a hydrogen produced by electrolysis of water using low carbon energy. Contrary to previous research work on hydrogen transport for road transport, we assume a more realistic assumption of demand side: we assume that only drivers driving more than 20,000 km per year will switch to fuel cell electrical vehicles. This corresponds to a total demand of 100TWh of electricity for the production of hydrogen by electrolysis. To meet this demand, we primarily use surplus electricity production from wind power. This surplus will satisfy approximately 10% of demand. We assume that the rest of the demand will be produced using the surplus from nuclear power plants disseminated in the regions. We assume also a decentralized production, namely that 100 MW electrolyzers will be placed near the electricity production plants. Using an optimization model, we define the hydrogen transport network by considering decentralized production. Then we compare it to more centralized production. Our main conclusion is that decentralized production makes it possible to significantly reduce distribution costs, particularly due to significantly shorter transport distances.- Book : ()
- Pub. Date : 2025
- Page :
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2025
India is characterized by strong temperature variations in different seasons ranging from mean temperature of about 10°C in winter to about 32 °C in summer season. The temperatures start to increase all over the country in March and by April; the interior parts of the peninsula record mean daily temperatures of 30-35 °C. Heat stress is a condition that is caused by worker’s over-exposure to the high temperature work environments often found in outdoor agriculture operations. Workers should be informed of the nature of heat stress and its adverse effects as well as the protective measures provided in the workplace. This operation was performed by traditionally used manually operated sickle, when the average dry bulb temperature was above 32°C which caused the heat stress during the work because of high humidity in the field. Head temperature, forehead temperature, oral temperature, left lower hand temperature, middle left-hand temperature, upper right-hand temperature, left upper chest temperature, right scapula temperature, left calf temperature and right anterior thigh temperature were measured to assess the effect of environmental heat direct sun radiation on selected farm workers during both the agricultural operations. To assess the effect of heat on the human body, physiological parameters like heart rate (HR) and oxygen consumption rate (OCR). Thermal parameters like oral, head, left lower hand, middle left hand, upper right hand, left upper chest, right scapula, left calf, right anterior thigh, mean skin temperatures of farm workers increased with increase in WBGT due to heat stress.- Book : 31(1)
- Pub. Date : 2025
- Page : pp.547-555
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2025
- Book : 1012()
- Pub. Date : 2025
- Page : pp.116810-116810
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2025
- Book : ()
- Pub. Date : 2025
- Page :
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2025
This paper deals with an experimental analysis of performance and emissions
of a single cylinder, air cooled, direct injection, compression ignition
engine using synthetic fuel extracted from Tilia B233 refrigerator
lubricating oil and waste cooking oil biodiesel. Biodiesel and synthetic
fuel are produced by transesterification process using methanol and
potassium hydroxide. Physical properties as well as liquid density, liquid
viscosity, total acidity number and flash point are measured. Physical
properties and their blends are compared with conventional diesel fuel
properties. A first insight to the results indicates that, unlike biodiesel,
synthetic fuel which is distinguished by their its low acidity, which
enables its storage. In addition, their viscosity is quite high and require
the use of synthetic fuel blends with diesel fuel. A careful investigation
according to current limitations and standards leads us to a direct engine
test with a maximum blending rate of 50%. Thus, blends are achieved by
mixing 15%, 30% and 45% of biodiesels with a complementary amount of
commercial diesel fuel. The experimental results are obtained on single
cylinder diesel engine operating at 1600 rpm for a wide range of loads.
Brake specific fuel consumption, specific NOx and CO emissions are compared
for each blend with those obtained by conventional diesel fuel.- Book : (00)
- Pub. Date : 2025
- Page : pp.11-11
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2025
Mitochondria are important organelles for cell metabolism and tissue survival. Their cell-to-cell transfer is important for the fate of recipient cells. Recently, bone marrow mesenchymal stem cells (BM-MSCs) have been reported to provide mitochondria to cancer cells and rescue mitochondrial dysfunction in cancer cells. However, the details of the mechanism have not yet been fully elucidated. In this study, we investigated the humoral factors inducing mitochondrial transfer (MT) and the mechanisms. BM-MSCs produced MT in colorectal cancer (CRC) cells damaged by 5-fluorouracil (5-FU), but were suppressed by the anti-high mobility group box-1 (HMGB1) antibody. BM-MSCs treated with oxidized HMGB1 had increased expression of MT-associated genes, whereas reduced HMGB1 did not. Inhibition of nuclear factor–κB, a downstream factor of HMGB1 signaling, significantly decreased MT-associated gene expression. CRC cells showed increased stemness and decreased 5-FU sensitivity in correlation with MT levels. In a mouse subcutaneous tumor model of CRC, 5-FU sensitivity decreased and stemness increased by the MT from host mouse BM-MSCs. These results suggest that oxidized HMGB1 induces MTs from MSCs to CRC cells and promotes cancer cell stemness. Targeting of oxidized HMGB1 may attenuate stemness of CRCs.- Book : 26(3)
- Pub. Date : 2025
- Page : pp.1192-1192
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