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2025
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AbstractPhotonics bound states in the continuum (BICs) are peculiar localized states in the continuum of free‐space waves, unaffected by far‐field radiation loss. Although plasmonic nano‐antennas squeeze the optical field to nanoscale volumes, engineering the emergence of quasi‐BICs with plasmonic hotspots remains challenging. Here, the origin of symmetry‐protected (SP) quasi‐BICs in a 2D system of silver‐filled dimers, quasi‐embedded in a high‐index dielectric waveguide, is investigated through the strong coupling between photonic and plasmonic modes. By tailoring the hybridizing plasmonic/photonic fractions, a trade‐off is selected at which the quasi‐BIC exhibits both high intrinsic Q‐factor and strong near‐field enhancement because of dimer‐gap hotspot activation. Not only radiation loss is damped but in a configuration sustaining a lattice of plasmonic hotspots. This leads to an advantageous small modal volume for enhancing light‐matter interaction. The layout of nearly embedded dimers is designed to maximize the spatial overlap between the optical field and the target molecules, enhancing reactive sensing efficiency. The architecture is evaluated for its ability to detect transactive response DNA‐binding protein 43. The refractometric sensitivity outperforms current label‐free biosensing platforms, reaching the zeptomolar range. The approach highlights the potential of combining plasmonic and dielectric nanomaterials for advanced sensing technologies.- Book : ()
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2025
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2025
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2025
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2025
AbstractINTRODUCTIONObservational studies have revealed a close relationship between reduced bone mineral density (BMD) and Alzheimer's disease (AD) risk. The receptor activator of nuclear factor kappa‐B ligand (RANKL) and osteoprotegerin (OPG) system, pivotal in regulating bone metabolism, has been implicated in brain function, but the causal impact on AD risk remains unclear.METHODSWe employed bi‐directional Mendelian randomization (MR) and multivariable MR (MVMR) approaches to elucidate the effect of blood soluble RANKL (sRANKL) and OPG levels on AD, assessing whether this influence was independent of BMD and inflammation. Three distinct AD genome‐wide association study (GWAS) data sets from the International Genomics of Alzheimer's Project (IGAP), UK Biobank (UKB), and FinnGen were utilized. Summary‐level data on blood sRANKL and OPG were sourced from deCODE Genetics.RESULTSGenetically predicted per standard deviation (SD) increase in blood sRANKL levels was significantly associated with a reduced risk of AD across all three AD GWAS data sets (IGAP: odds ratio [OR] = 0.82, 95% confidence interval [CI] = 0.72–0.94, p = 0.004; UKB: OR = 0.85, 95% CI = 0.78–0.91, p < 0.001; FinnGen: OR = 0.83, 95% CI = 0.73–0.94, p = 0.004). No significant causal relationship was observed between OPG levels and AD. In addition, there was no causal impact of AD on the blood levels of sRANKL and OPG. MVMR results showed that the inverse association between sRANKL and AD risk persisted after adjusting for BMD and interleukin‐1α and chemoattractant protein‐1.DISCUSSIONOur study provides evidence that elevated sRANKL levels are causally linked to a reduced risk of AD, independent of BMD and inflammation. These findings enhance our understanding of the complex interactions between bone metabolism and AD.Highlights
Blood soluble receptor activator of nuclear factor kappa‐B ligand (sRANKL) levels are linked to a reduced risk of Alzheimer's disease (AD).
The association between sRANKL levels and AD is independent of bone mineral density (BMD) and inflammation.
No causal link exists between blood osteoprotegerin levels and AD.
AD does not affect blood levels of sRANKL or osteoprotegerin.
- Book : 11(1)
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2025
In order to study the genetic diversity of silkworms (Bombyx mori L.) breeding in Azerbaijan, the following breeds and hybrids were analyzed: SHZEM 4 x GE 143, Chingiz x Yagub, Yagub x Chingiz, GE 143, Yagub, SHZEM 4 belted, Chingiz, GE 143 x SHZEM 4 using RAPD molecular markers. For this purpose, silkworm larvae were taken for DNA extraction and nuclear genome DNA was isolated from various parts of the silkworm (silk gland, epidermis, etc.). Four RAPD primers (BGN 04, BGL 02, BGY 06, BGA 02) were used in the study, resulting in 200-1200 bp 34 dots representing fragments. The average number of amplicons for each primer was 6-11, and 82-100% of the amplicons were polymorphic. The study found that RAPD markers do not fully reflect the similarity between the local breed and hybrids.- Book : 151()
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2025
Abstract
The High-Luminosity LHC will start operations for physics in 2029 and aims to record 3000 fb-1 of proton collision data. This expansion of the dataset will be achieved by a
four-fold increase in the number of collisions per bunch crossing, leading to
∼ 10× higher radiation doses and busier events. To cope with those harsher
conditions and to be compatible with the new ATLAS data acquisition paradigm, the ATLAS Liquid
Argon Calorimeter on-detector electronics will have to be replaced. The presentation will cover
the validation of the performance of the new boards, a critical step before launching the
full production of about 1500 boards and their installation which is planned to start in 2027.- Book : 20(01)
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2025
In this contribution, we report the measurement of D0 meson tagged jets in Au+Au collisions at √sNN = 200 GeV by the STAR experiment at RHIC. We present the nuclear modification factor RCP as a function of the jet transverse momentum and transverse momentum fraction of the jet, carried by D0 meson along the jet axis zJet, and the radial profile of the D0 meson. These results are compared to theoretical predictions provided by a hybrid transport model. Additionally, we show the raw measurement of several generalized angularities λκα, which describe the jet substructure. These results may help distinguish between different models describing jet quenching and heavy flavor quark in-medium energy loss.- Book : 316()
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- Page : pp.04013-04013
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