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2025
Fibrosis is a pathological process with few therapeutic options. Experimental molecules are being developed to counteract the fibrotic effects through TGFβ receptor inhibition. Additionally, phosphodiesterase 5 (PDE5) inhibitors also have anti-fibrotic effects; however, the mechanism of action remains unresolved. IPW5371 is an example of an experimental TGFβ-mediated anti-fibrotic compound, and tadalafil is an example of a PDE5 inhibitor. Irradiation increases the frequency of fibrotic lesions, driven by the activation of the TGFβ pathway. We hypothesized that the TGFβ receptor and PDE5 inhibitor agents would be additive in their ability to prevent fibrosis development in tissues in a sub-lethal whole-body irradiation mouse model. However, the combined use of anti-fibrotic agents, tadalafil and IPW5371, caused increased male mouse mortality associated with ascending and thoracic aortic rupture compared to mice that only received one of the drugs. Following histopathological analysis of the mouse hearts, we also observed that irradiation protected against lesions caused by the combination therapy as non-irradiated male mice had significantly worse outcomes as compared to irradiated male mice, substantiating the drug–drug interaction independent of the radiation effects. This important drug interaction needs further investigation as these agents are developed for anti-fibrosis therapy, and PDE5 inhibitors are commonly prescribed to male patients.- Book : ()
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2025
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2025
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2025
- Book : 25(1)
- Pub. Date : 2025
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2025
Using the color dipole picture for photon-nucleus interactions at small x together with the color glass condensate (CGC) effective theory, we demonstrate that the next-to-leading (NLO) order corrections to the cross section for the inclusive production of a pair of hard jets encode not only the Jalilian-Marian, Iancu, McLerran, Weigert, Leonidov and Kovner (JIMWLK) evolution with decreasing x, but also the Dokshitzer-Gribov-Lipatov-Altarelli-Parisi (DGLAP) evolution of the gluon distribution function and the Collins-Soper-Sterman (CSS) evolution of the gluon transverse momentum dependent (TMD) distribution. The emergent CSS equation takes the form of a rate equation describing the evolution of the dijet distribution in the transverse momentum imbalance K⊥ when increasing the dijet relative momentum P⊥. All three types of evolution become important when both P⊥ and K⊥ are much larger than the nuclear saturation momentum Qs(x) and we propose a framework which encompasses all of them. The solution to the JIMWLK equation provides the source term for the DGLAP evolution with increasing K⊥, which in turn generates the initial condition for the CSS evolution with increasing P⊥.
Published by the American Physical Society
2025
- Book : 111(7)
- Pub. Date : 2025
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2025
A central spin qubit interacting coherently with an ensemble of proximal spins can be used to engineer entangled collective states or a multiqubit register. Making full use of this many-body platform requires tuning the interaction between the central spin and its spin register. GaAs quantum dots offer a model realization of the central spin system where an electron qubit interacts with multiple ensembles of ∼104 nuclear spins. In this work, we demonstrate tuning of the interaction between the electron qubit and the nuclear many-body system in a GaAs quantum dot. The homogeneity of the GaAs system allows us to perform high-precision and isotopically selective nuclear sideband spectroscopy, which reveals the single-nucleus electronic Knight field. Together with time-resolved spectroscopy of the nuclear field, this fully characterizes the electron-nuclear interaction for control. An algorithmic feedback sequence selects the nuclear polarization precisely, which adjusts the electron-nuclear exchange interaction via the electronic g-factor anisotropy. This allows us to tune directly the activation rate of a collective nuclear excitation (magnon) and the coherence time of the electron qubit. Our method is applicable to similar central-spin systems and enables the programmable tuning of coherent interactions in the many-body regime.
Published by the American Physical Society
2025
- Book : 15(2)
- Pub. Date : 2025
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2025
The present paper analyzes the individual effects of three dimensions of
knowledge management on product and process innovations in the field of PV/T
technologies. Forms of a specially prepared questionnaire were adequately
filled in by 300 Serbian companies who already use, produce or plan to
produce some PV/T technology. The collected data were analyzed by means of
the partial least squares structural equation modeling algorithm in the
partial least squares path modeling software package version 0.5.0. The
survey was conducted in the period from May to September 2023 in 300 small-
and medium-sized companies. The findings show that knowledge acquisition,
knowledge storage, and knowledge sharing, as dimensions of knowledge
management, have positive effects on the implementation of product and
process innovations in the surveyed companies. However, it is revealed that
knowledge sharing has the greatest effect on the considered innovations in
companies dealing with PV/T technologies. In addition, the lowest effect is
obtained for the dimension of knowledge acquisition, while the effect of
knowledge storage is medium.- Book : (00)
- Pub. Date : 2025
- Page : pp.71-71
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