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2025
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2025
Not available.- Book : ()
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2025
Japan and China are in the list of resource-deficient countries, and this fact largely determines the importance of pursuing a targeted policy for the development of low-carbon energy sectors. This refers, first and foremost, to renewable energy and hydrogen, but it is also worth taking into account the growing role of peaceful nuclear energy – Japan, despite the consequences of the Fukushima accident, is gradually increasing the share of nuclear power plants in its generation structure. The authors show that the tasks of achieving “net zero emissions” facing Japan and China have many similar features. The countries under consideration, undoubtedly, have different financial and economic resources, different potential and available capacity of their domestic markets for the implementation of low-carbon energy technologies and products in a broad sense. However, they build public policy in this direction based on the incentive mechanisms that create their own technological foundation, taking into account what advanced solutions are being developed and implemented by their closest competitors. Over the past two decades, Japan and China have elaborated the format of energy cooperation where the emphasis was placed on the supply of energy and transport equipment from Japan, as well as investments by Japanese companies in the construction of various energy infrastructure objects in China. However, at present, China already has sufficient technological potential not only to meet its needs in the production of equipment and components for low-carbon energy, but also to export products of this type. Accordingly, Japanese corporations that used to hold leading positions in the renewable energy segment as suppliers of necessary equipment and initiators of technology transfer to developing countries (mainly in Southeast and South Asia), nowadays face competition with Chinese producers. It is shown that, despite the existing controversy, Japan and China keep a high level of bilateral contacts through intergovernmental organizations and funds, joint research centers, various private business cooperation mechanisms and schemes, all of which foster the implementation of large projects. - Book : (4)
- Pub. Date : 2025
- Page : pp.70-86
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2025
Background: The presence of level IV/V metastasis is a significant prognostic factor for patients with oral and oropharyngeal cancer, while level IV lymphadenopathy defines the N3 stage in nasopharyngeal carcinoma. However, the current staging system for hypopharyngeal squamous cell carcinoma (HPSCC) does not consider the location of involved nodes. Objectives: To evaluate the risk factors and prognostic impact of level IV/V metastasis in patients with HPSCC. Methods: The analysis included 2740 HPSCC patients from the SEER (Surveillance, Epidemiology, and End Results) database, followed by a validated study on 232 patients with pathologically positive nodes (pN+) at our center. Results: Of the 2740 patients, 1961 presented with metastatic lymph nodes (LNs), 20.8% and 14.1% had nodal involvement in level IV and level V, respectively. Multivariate analysis revealed that N3 and M1 stages were independently associated with level IV/V metastasis. Level IV metastasis was the sole independent adverse factor for overall survival (OS) among all LN regions ( p < 0.05). Regarding cancer-specific survival (CSS), only level IV and V involvement were independent predictors of prognosis ( p < 0.05). The rate of pN+ at levels IV and V in our center was 35.8% and 16.4%, respectively. The advanced pN stage was independently associated with metastasis to level IV or V. Patients with level IV/V metastasis had significantly higher rates of regional recurrence and distant metastases ( p < 0.001). Multivariate analysis confirmed a significant association regarding OS, CSS, locoregional relapse-free survival (LRFS), or distant metastasis-free survival between patients with and without level IV metastasis ( p < 0.05). Patients with level IV/V disease exhibited decreased survival rates across stages pN1 to pN3. Postoperative chemoradiotherapy improved LRFS in patients with level IV lymphadenopathy and OS/CSS in patients with level V metastasis. Conclusion: Metastasis to level IV/V was associated with a worse prognosis in HPSCC patients. The level IV/V should be considered for future improvements to the staging system. Design: A retrospective study. - Book : 17()
- Pub. Date : 2025
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2025
Massive stars (M* > 8 M⊙) play a pivotal role in shaping their galactic surroundings due to their high luminosity and intense ionizing radiation. However, the precise mechanisms governing the formation of massive stars remain elusive. Complex organic molecules (COMs) offer an avenue for studying star formation across the low- to high-mass spectrum because COMs are found in every young stellar object (YSO) phase and offer insight into the structure and temperature. We aim to unveil patterns in the evolution of COM chemistry in 41 massive young stellar objects (MYSOs) sourced from diverse catalogues, using Atacama Large Millimeter/Submillimeter Array Band 6 spectra. Previous line analysis of these sources revealed the presence of methanol, methyl acetylene, and methyl cyanide with diverse excitation temperatures (a few tens to hundreds of Kelvin) and column densities (spanning two to four orders of magnitude in range), indicating a possible evolutionary path across sources. However, such analyses usually involve manual line extraction and rotational diagram fitting. We improved upon this process by directly retrieving the physicochemical state of MYSOs from their dimensionally reduced spectra. We used a locally linear embedding to find a lower-dimensional projection for the physicochemical parameters obtained from individual line analysis. We identified clusters of similar MYSOs in the embedded space using a Gaussian mixture model, revealing three groups of MYSOs corresponding to distinct physicochemical conditions: (i) cold, COM-poor sources, (ii) warm, medium-COM-abundance sources, and (iii) hot, COM-rich sources. Principal component analysis (PCA) of the source spectra further supported an evolutionary path across MYSO groups. Finally, by training a simple random forest model on the first few PCA components, we found that the physicochemical state of MYSOs in our sample can be derived directly from the spectra. Our results highlight the effectiveness of dimensionality reduction in obtaining clear physical insights directly from MYSO spectra.- Book : 694()
- Pub. Date : 2025
- Page : pp.A20-A20
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2025
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2025
To enhance the floating raft vibration isolation system’s effect, a new two-stiffness floating raft vibration isolation experimental was constructed. First, the system’s mathematical model was established. The vibration transfer function was deduced via substructure derivative synthesis and four-end parameter matrix methods, and the structural parameter impacts on it were analyzed. Then, a modal test was conducted, and a finite element model was built. Comparing finite element analysis with test results verified the model’s validity, followed by a study of the support structure’s vibration characteristics. Finally, by measuring acceleration responses at the isolator’s upper and lower ends and using the difference as an evaluation index, the isolator’s vibration isolation effect on land and underwater was investigated, along with its impact on the device’s underwater acoustic radiation. The results demonstrate that the two-stiffness vibration isolator can reduce vibration transmission within a specific frequency range both on land and underwater, guiding practical engineering vibration isolation research.- Book : 13(2)
- Pub. Date : 2025
- Page : pp.254-254
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2025
Metastatic meningioma is rare, occurring in less than 1% of patients, and very few case studies have been reported, in particular for those that have spread to the lungs. Here we describe a rare case of metastatic meningioma to the lungs. Following a discussion at a medical oncology multi-disciplinary team meeting, whole genome sequencing was requested in November 2021 and discussed at a neurosurgical molecular tumor board in June 2022. Sequencing was performed on matched longitudinal collected samples of the primary tumor resection, the re-excised recurrent tumor after adjuvant radiation therapy, the lung metastases before treatment with sunitinib, and one paired blood sample for tumor-normal analysis. Whole genome characterization and clonal evolution analysis confirmed neurofibromatosis 2 (NF2) gene loss as the main driver of this cancer. In the same cancer clone as NF2, we identified a BRCA2 (p.E51K) mutation was present in all tumors, which may represent a potential driver event, though evidence supporting this is currently limited. Although this mutation is predicted to potentially influence homologous recombination, its clinical relevance as a biomarker for PARP inhibition remains speculative and requires further investigation. We also noted a SETD2 (p.S1885N) mutation that was present only in the recurrent tumor which was identified as a predicted biomarker of response to WEE1 inhibition. There was a stepwise increase in tumor mutational burden (TMB) from the primary meningioma to lung metastases, suggesting this patient may have been a candidate for immunotherapy.- Book : ()
- Pub. Date : 2025
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2025
In the last decades, the study of many nuclear envelope components in Dictyostelium amoebae has revealed conserved mechanisms of nuclear envelope dynamics that root back unexpectedly deep into the eukaryotic tree of life. In this review, we describe the state of the art in nuclear envelope research in this organism starting from early work on nuclear pore complexes to characterization of the first true lamin in a non-metazoan organism and its associated nuclear envelope transmembrane proteins, such as the HeH-family protein Src1 and the LINC complex protein Sun1. We also describe the dynamic processes during semi-closed mitosis, including centrosome insertion into the nuclear envelope, and processes involved in the restoration of nuclear envelope permeability around mitotic exit and compare them to the situation in cells with open or fully closed mitosis.- Book : 14(3)
- Pub. Date : 2025
- Page : pp.186-186
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2025
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