• Book : 221(1)
• Pub. Date : 2025
• Page :
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Abstract Cells navigating in complex 3D microenvironments frequently encounter narrow spaces that physically challenge migration. While in vitro studies identified nuclear stiffness as a key rate-limiting factor governing the movement of many cell types through artificial constraints, how cells migrating in vivo respond dynamically to confinement imposed by local tissue architecture, and whether these encounters trigger molecular adaptations, is unclear. Here, we establish an innovative in vivo model for mechanistic analysis of nuclear plasticity as Drosophila immune cells transition into increasingly confined microenvironments. Integrating live in vivo imaging with molecular genetic analyses, we demonstrate how rapid molecular adaptation upon environmental confinement (including fine-tuning of the nuclear lamina) primes leukocytes for enhanced nuclear deformation while curbing damage (including rupture and micronucleation), ultimately accelerating movement through complex tissues. We find nuclear dynamics in vivo are further impacted by large organelles (phagosomes) and the plasticity of neighbouring cells, which themselves deform during leukocyte passage. The biomechanics of cell migration in vivo are thus shaped both by factors intrinsic to individual immune cells and the malleability of the surrounding microenvironment.

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• Pub. Date : 2025
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Background/Objectives: Artificial intelligence (AI) is transforming neuroimaging by enhancing diagnostic precision and treatment planning. However, its applications in pediatric cancer neuroimaging remain limited. This review assesses the current state, potential applications, and challenges of AI in pediatric neuroimaging for cancer, emphasizing the unique needs of the pediatric population. Methods: A comprehensive literature review was conducted, focusing on AI’s impact on pediatric neuroimaging through accelerated image acquisition, reduced radiation, and improved tumor detection. Key methods include convolutional neural networks for tumor segmentation, radiomics for tumor characterization, and several tools for functional imaging. Challenges such as limited pediatric datasets, developmental variability, ethical concerns, and the need for explainable models were analyzed. Results: AI has shown significant potential to improve imaging quality, reduce scan times, and enhance diagnostic accuracy in pediatric neuroimaging, resulting in improved accuracy in tumor segmentation and outcome prediction for treatment. However, progress is hindered by the scarcity of pediatric datasets, issues with data sharing, and the ethical implications of applying AI in vulnerable populations. Conclusions: To overcome current limitations, future research should focus on building robust pediatric datasets, fostering multi-institutional collaborations for data sharing, and developing interpretable AI models that align with clinical practice and ethical standards. These efforts are essential in harnessing the full potential of AI in pediatric neuroimaging and improving outcomes for children with cancer.

• Book : 17(4)
• Pub. Date : 2025
• Page : pp.622-622
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Abstract Background Radiation-induced meningiomas represent a late side effect of cranial radiation therapy. The most widely used diagnostic criteria, despite the lack of a standard description, is a meningioma that develops in a previously irradiated area following a predetermined time interval. Case presentation We present four cases of late-onset cranial atypical meningiomas following childhood cranial radiotherapy. Four patients (two females and two males) between 4 and 13 years of age at the time of cranial irradiation developed secondary intracranial meningioma after a latency period of 8–34 years. Surgical resection of the tumors was performed, and histopathological examination revealed a diagnosis of atypical meningioma in all four patients. Conclusion Radiation-induced tumors continue to be a significant side effect of radiotherapy and radiosurgery, and they are frequently identified as recurrent, numerous, and more aggressive. Prolonged follow-up should definitely not be ignored in patients with antecedents of radiotherapy for a primary cerebral tumor or cranial irradiation for an early age malignancy.

• Book : 40(1)
• Pub. Date : 2025
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Abstract Determining stress and strain in a component of a fusion power plant involves defining boundary conditions for the mechanical equilibrium equations, which implies the availability of a full reactor model for defining those conditions. To address this fundamental challenge of reactor design, a finite element method (FEM) model for the Mega-Ampere Spherical Tokamak Upgrade (MAST-U) fusion tokamak, operating at the Culham Campus of UKAEA, has been developed and applied to assess mechanical deformations, strain, and stress in the full tokamak structure, taken as a proxy for a fusion power plant. The model, handling 127 million finite elements using about 800 processors in parallel, illustrates the level of fidelity of structural simulations of a complex nuclear device made possible by the modern supercomputing systems. The model predicts gravitational and atmospheric pressure-induced deformations in broad agreement with observations, and enables computing the spectrum of acoustic vibrations of a tokamak, arising from mechanical disturbances like an earthquake or a plasma disruption. We introduce the notion of the {\it density of stress} to characterise the distribution of stress in the entire tokamak structure, and to predict the magnitude and locations of stress concentrations. The model enables defining computational requirements for simulating a whole operating fusion power plant, and provides a digital foundation for the assessment of reactor performance as well as for specifying the relevant materials testing programme.

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• Pub. Date : 2025
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Reducing dehydrogenation temperature while preserving high hydrogen generation capacity obstructs the hydrolysis of sodium borohydrides (NaBH4). The two-dimensional (2D) MAX phase of titanium aluminum carbide (Ti3AlC2) and MXene (Ti3C2Tx) multilayers was investigated for hydrogen generation via NaBH4 hydrolysis with and without light. The material was characterized using X-ray diffraction (XRD), Fourier transform infrared (FT-IR), transmission electron microscopy (TEM), high-resolution TEM (HR-TEM), scanning electron microscopy (SEM), and diffuse reflectance spectroscopy (DRS). The activity of Ti3AlC2 was significantly enhanced by the integration of UV light radiation during hydrolysis. Ti3AlC2/Ti3C2Tx improved the dehydrogenation rates of NaBH4 at ambient conditions and maintained high hydrogen generation rates (HGRs) over time compared to a conventional method. It exhibited a HGR of 200–300 mL·min−1·g−1. Photo-assisted hydrolysis over the catalyst can be maintained for several times at ambient temperature. The catalyst demonstrated effective performance even after five cycles of usage.

• Book : 13(2)
• Pub. Date : 2025
• Page : pp.44-44
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• Pub. Date : 2025
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• Pub. Date : 2025
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In this paper, the numerical method is used to investigate the flow around two tandem teardrop cylinders for four different arrangements at low Reynolds numbers. The influence of Reynolds number and spacing ratio on the drag, lift coefficient and Strouhal number are calculated and analyzed. The Reynolds number ranges from 50 to 200, while the spacing ratio ranges from 0 to 15. The results indicate that the Reynolds number has a more significant effect than the spacing ratio on the two tandem teardrop cylinders. Moreover, the influence of Reynolds number and spacing ratio on drag and lift coefficients can be divided into three regions. The drag and lift coefficients exhibit regular variations in the front and rear regions, and irregularly in the intermediate region, which are 140~ 170,125 ~ 140,80 ~ 125 and 125 ~ 140 at Reynolds number and concentrated in 2.4-2.8 ?S <6 in spacing ratio for the four arrangements. A sudden increase present in both cylinders in all arrangements, except for the drag coefficient of the upstream cylinder which varies with Reynolds number. For a fixed spacing ratio or Reynolds numbers, constant vortex shedding is observed in cylinders with the various of Re or S. Arrangement A shows the latest onset of vortex shedding, regardless variations in the Reynolds number or the the spacing ratio. Additionally, intermittent vortex shedding is noted in Arrangements A and C before transitioning to a constant state. Overall, compared to the circular cylinders in tandem arrangement, the teardrop cylinders demonstrate superior flow characteristics. The results will provide a certain theoretical foundation for applications in engineering practice.

• Book : (00)
• Pub. Date : 2025
• Page : pp.9-9
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Background: Breast cancer (BC) is a common type of malignancy in females in Iraq. This study investigated BC's clinical and diagnostic features in 30 women and displayed its relationship with periodontal disease. Methods: This cross-sectional study comprised 30 BC patients diagnosed in 2023. The clinical signs, ultrasound, biopsy, histopathology and Immunohistochemistry, treatment modules, and clinical signs of periodontal disease were reported and analyzed. Results: The mean and standard deviation of patients’ age was 51.73± 11.41. The location of Breast Cancer lesions was on the left and right sides in 11 (36.66%) and 19 (63.33%) patients, respectively. All patients showed various sizes of non-painful lumps with well-defined masses in different areas of the breast tissue with regular or irregular borders in ultrasound and MRI. The gross and histopathological changes of cancerous tumors differed according to conditions, stage, and interaction with the cancer receptors in Immunohistochemistry. The percentage of metastases was 100% (in 30 cases) for the lymph nodes and 66.66%  (in 20 cases) for the rest of the other organs. Different treatment modules were used, including chemotherapy, surgery, radiation, and hormonal therapy. The cases suffering from mild, moderate, and severe periodontal disease were 7 (23.33 %), 2 (6.66%), and 21 (70%), respectively. Conclusion: The clinical signs, histopathological, IHC, and occurrence of periodontal disease in 30 women with breast cancer were documented in this study.  The authors recommend further studies on breast cancer to support its early diagnosis and prevention strategies.

• Book : 12(1)
• Pub. Date : 2025
• Page : pp.85-98
• Keyword :