The invention provides methods of using chloroplast-selectable markers to detect nuclear genome editing. The methods involve selecting a genetic modification that has occurred in a nuclear genome of a photosynthetic cell; transforming a photosynthetic cell with a ribonucleoprotein complex that effects a genetic modification in the genome in the nucleus of a photosynthetic cell; transforming the photosynthetic cell with a construct that effects an insertion of a selectable marker into the plastome of a plastid of the cell; selecting for photosynthetic cells having the selectable marker inserted into the plastome; and thereby selecting for the genetic modification to the genome in the nucleus of the photosynthetic cell.

• 출원번호 : 18793396
• 출원인 : Verruto, John
• 특허번호 :
• IPC : C12N-015/82(2006.01);C12N-009/22(2006.01);C12N-015/11(2006.01);C12N-015/89(2006.01);

The present disclosure relates to the identification of gene signature panels and tumor characteristics for predicting solid tumors (e.g., lung cancer) response to immune checkpoint blockade and/or radiation therapy, and methods of uses thereof.

• 출원번호 : US2024/040687
• 출원인 : CORNELL UNIVERSITY
• 특허번호 :
• IPC : C12Q-001/6886(2018.01)

The present invention relates to a screen (1) made of radioprotective material(s) for protecting an operator against emissions of ionising radiation such as X-rays or others, the screen comprising a rear face of the screen (2) facing which the operator is intended to be positioned, and a front face of the screen (3) opposite the rear face of the screen (2). According to the invention, this screen (1) comprises means (17, 17a) for generating a luminous marking (18, 18a) on the ground, suitable for delimiting a zone (C) considered to be a protective zone on the side of the rear face of the screen (2).

• 출원번호 : EP2024/072036
• 출원인 : LEMER PAX
• 특허번호 :
• IPC : A61B-006/10(2006.01)

An apparatus comprises an electronic component comprising at least one circuit, a shielding material, coupled to the electronic component, forming a protective shield over or partially surrounding said at least one circuit. The protective shield comprises one or more layers formed of a composite material. At least one layer of said is disposed on the electronic component to form the protective shield protecting the electronic component from radiation. The composite material comprises a polymer composite comprising an arrangement of carbon material to increase the emissivity of the composite material, and/or a thermal conductive coating disposed over said at least one layer facing toward the electronic component and/or a thermal reflective coating disposed over said at least one layer facing away from the electronic component.

• 출원번호 : US2024/040790
• 출원인 : COSMIC SHIELDING CORPORATION;SIHVER, Lembit;BARGHOUTY, Fakhri, Yanni;
• 특허번호 :
• IPC : H05K-009/00(2006.01)

A fuel element (1) for a nuclear reactor comprises a box structure (3), containing fuel bars (10), and at least one foot (2) and one head (5) positioned at respective opposite longitudinal ends of the box structure (3); the foot (2) being provided with at least one opening (2b) to allow in use reactor core cooling fluid to enter inside the box structure (3); the foot (2) is provided with a shutter member (30) cooperating with a peripheral edge (37b) of the opening (2b) to selectively open and close the opening (2b), so as to allow circulation of cooling fluid within the box structure (3) during reactor operation, and to prevent circulation of cooling fluid and keep the box structure (3) filled with cooling fluid during and after extraction of the fuel element from the reactor core, even in gas environment.

• 출원번호 : IB2024/057505
• 출원인 : NEWCLEO S.R.L.
• 특허번호 :
• IPC : G21C-003/322(2006.01);G21C-015/18(2006.01);G21C-015/28(2006.01);

The invention relates to a stroboscopic light-emitting device (1) for locating purposes, comprising a housing (10) provided with an infrared light emitter (20), a stabilised power supply module (40) contained in the housing and coupled to an electric accumulator (50), and a control module (30) also contained in the housing (10) and capable of controlling the duration and frequency of emission of the emitter (20) so as to generate a strobe light signal, characterised in that the light emitter consists of an infrared thermal emitter (20) comprising a heating element (21) through which an electric current is able to flow such that it causes the heating of the element and the emission of infrared thermal radiation.

• 출원번호 : EP2024/072058
• 출원인 : ACTION COMMUNICATION
• 특허번호 :
• IPC : G08B-005/00(2006.01);G08B-005/38(2006.01);F21L-004/00(2006.01);

The invention provides methods of using chloroplast-selectable markers to detect nuclear genome editing. The methods involve selecting a genetic modification that has occurred in a nuclear genome of a photosynthetic cell; transforming a photosynthetic cell with a ribonucleoprotein complex that effects a genetic modification in the genome in the nucleus of a photosynthetic cell; transforming the photosynthetic cell with a construct that effects an insertion of a selectable marker into the plastome of a plastid of the cell; selecting for photosynthetic cells having the selectable marker inserted into the plastome; and thereby selecting for the genetic modification to the genome in the nucleus of the photosynthetic cell.

• 출원번호 : US2024/040732
• 출원인 : VIRIDOS, INC.
• 특허번호 :
• IPC : C12N-015/64(2006.01);C12N-015/87(2006.01);C12N-015/63(2006.01);C12N-015/65(2006.01);C12N-015/66(2006.01);C12N-015/82(2006.01);

SOLUTION: Disclosed is a dark field digital holography microscope which is configured to determine features of interest of a structure. The dark field digital holography microscope comprises: a luminaire which is configured to provide at least a first beam pair including a first illumination radiation beam and a first reference radiation beam, and a second beam pair including a second illumination radiation beam and a second reference radiation beam; and one or multiple optical elements which can operate so as to capture first scattering radiation and second scattering radiation scattered by the structure and generated from a first illumination beam and a second illumination beam, respectively. Beams of the first beam pair are coherent mutually, and beams of the second beam pair are coherent mutually. The luminaire is configured to apply incoherence between the first beam pair and the second beam pair.SELECTED DRAWING: Figure 10

• 출원번호 : 2024127596
• 출원인 : ASML NETHERLANDS BV
• 특허번호 :
• IPC : G02B-021/06(2006.01);G03H-001/04(2006.01);G01B-011/02(2006.01);G01B-009/021(2006.01);

PROBLEM TO BE SOLVED: To provide newly improved treatment of liver cancers, in particular hepatocellular carcinoma.SOLUTION: The disclosure relates to compositions and methods for treating liver cancer, in particular, hepatocellular carcinoma using an antisense (AS) nucleic acid against an insulin-like growth factor 1 receptor (IGF-1R). The AS allows for systemic administration to the patient or is used for producing an autologous cancer cell vaccine. In embodiments, the AS is provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated with radiation and implanted in the abdomen of the subject and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of liver cancer.SELECTED DRAWING: Figure 1A

• 출원번호 : 2024127685
• 출원인 : UNIV THOMAS JEFFERSON
• 특허번호 :
• IPC : C12N-005/10(2006.01);C12N-015/113(2010.01);

A distributed computing system for a space flight environment includes a radiation hardened single board computer and a peripheral board including a radiation hardened processor module. The radiation hardened single board computer includes a first radiation hardened processor and a first radiation hardened field programmable gate array. The radiation hardened processor module includes a second radiation hardened processor and a second radiation hardened field programmable gate array. The radiation hardened processor module is connected to the radiation hardened single board computer through a VPX backplane.

• 출원번호 : 18793416
• 출원인 : Morgan, Keith S.
• 특허번호 :
• IPC : G21K-001/10(2006.01);G01T-001/36(2006.01);