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Copper oxidation at low temperatures below 140 ◦C and its effects on corrosive behavior in aerobic groundwater are investigated to estimate the intactness of canisters at early stages of disposal. The Cu coupon surface is covered by fine particles that form thin oxide layers after 30 d of oxidation; a thin Cu2O layer of thickness <100 nm is formed after oxidation at 40 ◦C; after oxidation at 140 ◦C, the Cu2O surface changes to a CuO layer of thickness <500 nm. The thickness of the Cu surface oxidized at 90 ◦C is between those of the surfaces oxidized at 40 and 140 ◦C. All Cu coupons exhibit similar current densities ranging from 0.77 to 1.87 μA cm􀀀 2, although the corrosion potential of the Cu coupon layered with Cu2O is higher than that of the others. Long-term oxidation tests for 406 d reveal no significant changes in the Cu surface at temperatures below 90 ◦C, indicating no significant change in the electrochemical behavior. The results of this study suggest that the storage of canisters at temperatures below 90 ◦C has no significant effect on the degradation of canister performance in long-term disposal

• Book : 57(1)
• Pub. Date : 2025
• Page : pp.1-7
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Purpose Cancer has become a significant major public health concern, making the discovery of new cancer markers or therapeutic targets exceptionally important. Elevated expression of tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) expression has been observed in certain types of cancer. This project aims to investigate the function of TNFRSF12A in tumors and the underlying mechanisms.Materials and Methods Various websites were utilized for conducting the bioinformatics analysis. Tumor cell lines with stable knockdown or overexpression of TNFRSF12A were established for cell phenotyping experiments and subcutaneous tumorigenesis in BALB/c mice. RNA-seq was employed to investigate the mechanism of TNFRSF12A.Results TNFRSF12A was upregulated in the majority of cancers and associated with a poor prognosis. Knockdown TNFRSF12A hindered the colorectal cancer progression, while overexpression facilitated malignancy both in vitro and in vivo. TNFRSF12A overexpression led to increased nuclear factor кB (NF-κB) signaling and significant upregulation of baculoviral IAP repeat containing 3 (BIRC3), a transcription target of the NF-κB member RELA, and it was experimentally confirmed to be a critical downstream factor of TNFRSF12A. Therefore, we speculated the existence of a TNFRSF12A/RELA/BIRC3 regulatory axis in colorectal cancer.Conclusion TNFRSF12A is upregulated in various cancer types and associated with a poor prognosis. In colorectal cancer, elevated TNFRSF12A expression promotes tumor growth, potentially through the TNFRSF12A/RELA/BIRC3 regulatory axis.

• Book : 57(1)
• Pub. Date : 2025
• Page : pp.212-228
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Homogeneity is an important factor for ensuring the structural stability of solidified radioactive waste, and the most effective approach for assessing its homogeneity is by performing compressive strength measurements using the minimum amount of coring specimens. The efficiency of detecting inhomogeneous waste is affected by the coring position and number of coring positions. However, no guidelines exist for coring solidified waste for compressive-strength tests. Therefore, this study compared uniform, random, and quasi-Monte Carlo sampling methods to determine the most effective core position. Further, the effects of different sampling amounts on the detection rate of inhomogeneous solidified waste were observed, and the detection rate of the inhomogeneous waste was obtained by modeling the coring procedure of solidified radioactive waste using MATLAB. Thus, a sampling method and a method for increasing the specimen amount, both of which can efficiently detect inhomogeneous waste during compressive strength tests, were presented in this paper. The results of this study can be applied as background data for developing homogeneity assessment guidelines for solidified radioactive waste.

• Book : 57(1)
• Pub. Date : 2025
• Page : pp.1-11
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• Book : 16(4)
• Pub. Date : 2025
• Page : pp.1051-1053
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