Study Design Narrative Review. Objective Contextualized by a narrative review of recent literature, we propose a wound complication prevention and management algorithm for spinal oncology patients. We highlight available strategies and motivate future research to identify optimal and individualized wound management for this population. Methods We conducted a search of recent studies (2010-2022) using relevant keywords to identify primary literature in support of current strategies for wound complication prevention and management following spine tumor surgery. When primary literature specific to spine tumor cases was not available, data were extrapolated from studies of other spine surgery populations. Results were compiled into a proposed clinical algorithm to guide practice considering available evidence. Results Based on available literature, we recommend individualized stratification of patients according to identifiable risk factors for wound complication and propose several interventions which might be employed preventatively, including intrawound antibiotic administration, negative pressure wound therapy, and primary flap closure of the surgical wound. Of these, the available evidence, weighing possible risks vs benefits, most strongly favors primary flap closure of surgical wounds, particularly for patients with multiple risk factors. A secondary algorithm to guide management of wound complications is also proposed. Conclusions Wound complications such as SSI and dehiscence remain a significant source of morbidity following spine tumor surgery. Triaging patients on an individualized basis according to risk factors for complication may aid in selecting appropriate prophylactic strategies to prevent these complications. Future research in this area is still needed to strengthen recommendations.

• Book : 15(1_suppl)
• Pub. Date : 2025
• Page : pp.143S-156S
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AbstractCoupled‐cavity mini‐array vertical‐cavity surface‐emitting lasers (VCSELs) are promising laser sources for high‐speed data transmission due to their extended intensity modulation frequencies. Here, it is demonstrated for the first time how to use such a 2 × 1 mini‐array VCSEL for the photonic generation of CW THz radiation. The emission frequencies of the cavities are tuned via current and provide the beat frequency for the photoconductive antennae. With coherent lock‐in detection we measured frequencies up to 300 GHz, making the mini‐array VCSEL an extremely simple and low‐cost alternative laser source for frequency‐modulated continuous‐wave radar or spectroscopy systems.

• Book : 61(1)
• Pub. Date : 2025
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• Book : 14(1)
• Pub. Date : 2025
• Page : pp.1-15
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Copper oxidation at low temperatures below 140 ◦C and its effects on corrosive behavior in aerobic groundwater are investigated to estimate the intactness of canisters at early stages of disposal. The Cu coupon surface is covered by fine particles that form thin oxide layers after 30 d of oxidation; a thin Cu2O layer of thickness <100 nm is formed after oxidation at 40 ◦C; after oxidation at 140 ◦C, the Cu2O surface changes to a CuO layer of thickness <500 nm. The thickness of the Cu surface oxidized at 90 ◦C is between those of the surfaces oxidized at 40 and 140 ◦C. All Cu coupons exhibit similar current densities ranging from 0.77 to 1.87 μA cm􀀀 2, although the corrosion potential of the Cu coupon layered with Cu2O is higher than that of the others. Long-term oxidation tests for 406 d reveal no significant changes in the Cu surface at temperatures below 90 ◦C, indicating no significant change in the electrochemical behavior. The results of this study suggest that the storage of canisters at temperatures below 90 ◦C has no significant effect on the degradation of canister performance in long-term disposal

• Book : 57(1)
• Pub. Date : 2025
• Page : pp.1-7
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Purpose Cancer has become a significant major public health concern, making the discovery of new cancer markers or therapeutic targets exceptionally important. Elevated expression of tumor necrosis factor receptor superfamily member 12A (TNFRSF12A) expression has been observed in certain types of cancer. This project aims to investigate the function of TNFRSF12A in tumors and the underlying mechanisms.Materials and Methods Various websites were utilized for conducting the bioinformatics analysis. Tumor cell lines with stable knockdown or overexpression of TNFRSF12A were established for cell phenotyping experiments and subcutaneous tumorigenesis in BALB/c mice. RNA-seq was employed to investigate the mechanism of TNFRSF12A.Results TNFRSF12A was upregulated in the majority of cancers and associated with a poor prognosis. Knockdown TNFRSF12A hindered the colorectal cancer progression, while overexpression facilitated malignancy both in vitro and in vivo. TNFRSF12A overexpression led to increased nuclear factor кB (NF-κB) signaling and significant upregulation of baculoviral IAP repeat containing 3 (BIRC3), a transcription target of the NF-κB member RELA, and it was experimentally confirmed to be a critical downstream factor of TNFRSF12A. Therefore, we speculated the existence of a TNFRSF12A/RELA/BIRC3 regulatory axis in colorectal cancer.Conclusion TNFRSF12A is upregulated in various cancer types and associated with a poor prognosis. In colorectal cancer, elevated TNFRSF12A expression promotes tumor growth, potentially through the TNFRSF12A/RELA/BIRC3 regulatory axis.

• Book : 57(1)
• Pub. Date : 2025
• Page : pp.212-228
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