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• Pub. Date : 2025
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The work is devoted to studying the composition for grain (barley and wheat) by terahertz (THz) high-resolution gas spectroscopy. The comparison of the set of chemical compounds formed during thermal decomposition of grain and cereals produced from grain was carried out with using a high-resolution spectrometer with phase-switching of radiation in the range of 115-175 GHz acting on studied gas developed by the authors. Free online spectroscopy databases were used for identification of substances. The results of comparison of molecular profiles of gas mixtures of thermal decomposition products of two varieties of barley, pearl barley and one variety of wheat are presented. Good agreement of the molecular composition for barley and pearl barley and some difference from the composition of the mixture obtained by heating wheat are shown.

• Book : 2025(1)
• Pub. Date : 2025
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• Pub. Date : 2025
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Abstract Background Cutaneous hypertrophic scar is a fibro-proliferative hard-curing disease. Recent studies have proved that antagonists of angiotensin II type 1 receptor (AT1R) and agonists of type 2 receptor (AT2R) were able to relieve hypertrophic scar. Therefore, establishing new methods to pursue dual-target lead compounds from Chinese herbs is in much demand for treating scar. Methods To this end, we immobilized AT1R or AT2R onto the surface of silica gel from cell lysates through a specific covalent bond by bioorthogonal chemistry. The columns containing immobilized AT1R or AT2R were jointly utilized to pursue potential bioactive compounds simultaneously binding to AT1R and AT2R from the extract of Rhei Radix et Rhizoma. Their functions on AT1R and AT2R expressions were investigated by in vitro and in vivo experiments. Results Aloe-emodin and emodin were identified as the potential bioactive compounds binding to both of the two receptors, thereby improving the appearance and pathomorphology of hypertrophic scar. They blocked the AT1R pathway to down-regulate the expression of transforming growth factor-β1 (TGF-β1) and stimulate matrix metalloproteinase-1 (MMP-1) expression. As such, the expression of collagen I/III reduced. Conversely, the bindings of the two compounds to AT2R reduced the production of nuclear factor-кB1 (NF-кB1), whereby the generation of interleukin-6 (IL-6) was blocked. Conclusion We reasoned that aloe-emodin and emodin had the potential to become dual-target candidates against hypertrophic scar through the regulation of AT1R and AT2R signaling pathways. It showed considerable potential to become a universal strategy for pursuing multi-target bioactive compounds from Chinese herbs by the utilization of diverse immobilized receptors in a desired order.

• Book : 20(1)
• Pub. Date : 2025
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Porcine circovirus type 2 (PCV2) is a significant pathogen responsible for porcine circovirus-associated diseases (PCVAD), and it is widely prevalent in pig farms, leading to huge economic losses for the pig industry. Currently, the ability of PCV2 to enhance its own replication by using the antiviral inflammatory factors IFNα, IFNβ, and IL-2 and its complex immune escape mechanism remain unclear, which has attracted wide attention. Research has indicated that GTPase-activating protein (SH3 domain)-binding protein 1 (G3BP1) is involved in the innate immune response to a variety of viruses, primarily by regulating and composing stress granules (SGs) to inhibit viral replication. Our initial studies identified elevated G3BP1 expression during PCV2 infection, paradoxically promoting PCV2 replication. In light of this phenomenon, this study aims to elucidate how PCV2 regulates G3BP1 to enhance its replication. Our findings demonstrate that G3BP1 overexpression further activates PCV2-induced expression of RIG-I, MDA5, cGAS and STING, thereby promoting IFNβ production and affecting cell cycle arrest in the S phase, facilitating PCV2 replication. Moreover, interactions were observed between PCV2 Cap protein and G3BP1’s RGG domain, and between PCV2 Rep protein and G3BP1’s NTF2 and RRM domains, potentially promoting viral protein nuclear transfer. In summary, PCV2 enhances its replication by modulating G3BP1 to induce IFNβ production and directly binds viral proteins to promote viral protein nuclear transfer. This research provides a foundation for further investigation into the immune evasion mechanisms of PCV2.

• Book : 26(3)
• Pub. Date : 2025
• Page : pp.1083-1083
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• Pub. Date : 2025
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AbstractCoupled‐cavity mini‐array vertical‐cavity surface‐emitting lasers (VCSELs) are promising laser sources for high‐speed data transmission due to their extended intensity modulation frequencies. Here, it is demonstrated for the first time how to use such a 2 × 1 mini‐array VCSEL for the photonic generation of CW THz radiation. The emission frequencies of the cavities are tuned via current and provide the beat frequency for the photoconductive antennae. With coherent lock‐in detection we measured frequencies up to 300 GHz, making the mini‐array VCSEL an extremely simple and low‐cost alternative laser source for frequency‐modulated continuous‐wave radar or spectroscopy systems.

• Book : 61(1)
• Pub. Date : 2025
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• Book : 14(1)
• Pub. Date : 2025
• Page : pp.1-15
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• Pub. Date : 2025
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