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2025
ABSTRACTBackgroundThe comparative effectiveness of radiotherapy and surgery for treating intracranial meningioma is unknown.ObjectivesTo compare survival after treatment of suspected intracranial meningioma by either surgery or radiotherapy.AnimalsTwo hundred eighty‐five companion dogs with suspected intracranial meningiomas presenting to 11 specialty clinics in three countries.MethodsParallel cohort comparison study on retrospective data. Dogs diagnosed with intracranial meningioma by board‐certified veterinary neurologists or radiologists and treated by radiotherapy or surgery were identified through medical record searches and presenting and survival data extracted. Lesion site was classified as rostro‐ or caudotentorial and size was measured on contrast magnetic resonance images. Outcome was all‐cause death. Analysis of survival by Cox proportional hazards, including selection for optimal multivariable model using lasso, counterfactual modeling including variables associated with treatment allocation and survival.ResultsOne hundred sixty‐eight dogs received radiotherapy and 117 received surgery. All analyses indicated reduced survival associated with surgery compared to radiotherapy. There was a median survival after surgery of 297 (IQR: 99–768) days compared with 696 (IQR: 368–999) for dogs treated by radiation, associated with a univariable hazard ratio of 1.802 (95% CI: 1.357–2.394). Counterfactual modeling estimated a mean survival of 480 (95% CI: 395–564) days after surgery and 673 (95% CI: 565–782) days after radiotherapy, representing a decrease in survival of 29%. Location and size of the lesion were not associated with survival duration.Conclusions and Clinical ImportanceDogs with suspected intracranial meningioma have substantially superior survival after radiotherapy compared to surgery.- Book : 39(2)
- Pub. Date : 2025
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2025
Gold nanoparticles (GNPs) have gained significant attention as multifunctional agents in biomedical applications, particularly for enhancing radiotherapy. Their advantages, including low toxicity, high biocompatibility, and excellent conductivity, make them promising candidates for improving treatment outcomes across various radiation sources, such as femtosecond lasers, X-rays, Cs-137, and proton beams. However, a deeper understanding of their precise mechanisms in radiotherapy is essential for maximizing their therapeutic potential. This review explores the role of GNPs in enhancing reactive oxygen species (ROS) generation through plasmon-induced hot electrons or radiation-induced secondary electrons, leading to cellular damage in organelles such as mitochondria and the cytoskeleton. This additional pathway enhances radiotherapy efficacy, offering new therapeutic possibilities. Furthermore, we discuss emerging trends and future perspectives, highlighting innovative strategies for integrating GNPs into radiotherapy. This comprehensive review provides insights into the mechanisms, applications, and potential clinical impact of GNPs in cancer treatment.- Book : 15(4)
- Pub. Date : 2025
- Page : pp.317-317
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2025
AbstractIn this paper, the effect of gamma‐ray irradiation on the electrical conductivity of polypropylene (PP) composites has been studied. The samples are prepared using PP and styrene–ethylene–butylene–styrene elastomer with contents ranging from 0 wt% to 50 wt%, and exposed to Cobalt‐60 gamma irradiation, with a dose from 0 to 250 kGy. Electrical conductivities at different temperatures and trap distributions are measured to observe the deterioration of insulation performance. The microstructure of the sample is estimated using differential scanning calorimetry, X‐ray diffraction, thermogravimetric analysis and a scanning electron microscope. The obtained results demonstrate a correlation between the increase in electrical conductivity and the elevation in both total dose and temperature. At 250 kGy, the trap distribution tends to become shallower, accompanied by a decrease in crystallinity, melting and decomposition temperatures of the sample. The PP composite exhibits better stability against irradiation and thermal effects, primarily due to the cross‐linked structures formed by irradiation.- Book : ()
- Pub. Date : 2025
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2025
AbstractWe investigate if mesoscale self‐organisation of trade cumuli in 150 km‐domain large‐eddy simulations modifies the top‐of‐atmosphere radiation budget relative to 10 km‐domain simulations, across 77 characteristic, idealized environments. In large domains, self‐generated mesoscale circulations produce fewer, larger and deeper clouds, raising the cloud albedo. Yet they also precipitate more than small‐domain cumuli, drying and warming the cloud layer, and reducing cloud cover. Consequently, large domains cool slightly less through the shortwave cloud‐radiative effect, and slightly more through clear‐sky outgoing longwave radiation, for a net cooling (−0.5 W ). This cooling is generally smaller than the large‐domain radiation's sensitivity to large‐scale meteorological variability, which is similar in small‐domain simulations and observations. Hence, mesoscale self‐organisation would not alter weak trade‐cumulus feedback estimates previously derived from small‐domain simulations. We explain this with a symmetry hypothesis: ascending and descending branches of mesoscale circulations symmetrically increase and reduce cloudiness, weakly modifying the mean radiation budget.- Book : 52(3)
- Pub. Date : 2025
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2025
Background: Sub clinical hypothyroidism is defined as thyroid stimulating hormone (TSH) >4.2 mIU/ml with a normal level of free T3 and free T4. The prevalence of sub clinical hypothyroidism in adults’ ranges from 1-10%, being higher in the elderly and in females. In children and adolescents, the prevalence is estimated to be less than 2%. Usually children and adolescents with sub clinical hypothyroidism have minimal signs and symptoms and the diagnosis is mostly made incidentally. Objective of the study was evaluation of clinical and etiological characteristics of children and adolescents with sub clinical hypothyroidism and to look at long term consequences in terms of progression to overt hypothyroidism.
Methods: Children in the age group of 5-18 years who were referred to the Department of Thyroid and Endocrine Research of Institute of Nuclear Medicine and Allied Sciences (INMAS), from April 2022 to October 2024 with the diagnosis of sub clinical hypothyroidism were recruited for the study. They were followed up for a period of two years.
Results: 52 cases of sub clinical hypothyroidism included 33 girls and 19 boys in the age group of 5-18 years. At the end of two year follow up period, in 67.3% of our patients, TSH reverted to normal range spontaneously without any treatment and only 17 patients (32.7%) progressed to overt hypothyroidism and were initiated levothyroxine replacement therapy.
Conclusions: Sub clinical hypothyroidism in children is a benign and self-limiting condition with low rate of progression to overt hypothyroidism.- Book : 13(2)
- Pub. Date : 2025
- Page : pp.757-760
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2025
ABSTRACTObjectivesStage III non‐small cell lung cancer (NSCLC) treatment remains challenging, with a multitude of treatment options available. We assessed Stage IIIA NSCLC outcomes by treatment received.MethodsWe performed a single‐institution retrospective review of NSCLC patients with Stage IIIA disease treated January 01, 2010—March 01, 2022. Demographics, treatments, outcomes, and failure patterns were collected. Progression‐free survival (PFS) and overall survival (OS) were assessed using Kaplan–Meier analysis. Failure patterns were assessed for differences using chi‐square analysis.ResultsOf 270 Stage III NSCLC patients, 134 had Stage IIIA disease with a median follow‐up of 29.9 months and a median age of 66 years (IQR 60–75). 66 (49.3%) patients were male, and 105 (78.4%) were current/former smokers (with 30 median pack‐years). Patients were treated with definitive radiation with/without chemotherapy (CRT; n = 77, 57.5%), surgery with neoadjuvant chemotherapy and/or radiation (Neoadj; n = 42, 31.3%), and surgery without neoadjuvant therapy (Surg; n = 15, 11.2%). Median PFS was 25.4 months (95% CI 12.5–42.6) for CRT, 22.6 months (95% CI 12.2–44.4) for Neoadj, and 22.8 months (95% CI 5.2‐NA) for Surg with no significant intergroup difference (p = 0.99). Median OS was 57.0 months (95% CI 37.4–77.5) for CRT, 51.5 months (95% CI 36.7–65.5) for Neoadj, and 35.3 months (95% CI 16.8‐NR) for Surg with no significant intergroup difference (p = 0.99).ConclusionsIn this single institution retrospective study, we find no significant differences in PFS, OS, and failure patterns between patients with Stage IIIA NSCLC treated with definitive (chemo)radiation and surgery with or without neoadjuvant therapy. Further work in the immunotherapy era is needed.- Book : 16(3)
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2025
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2025
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- Pub. Date : 2025
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2025
With the increasing utilization of renewable energy sources, hydrogen production from complementary wind and solar (HPCWS) systems has become a part of the construction of the integrated energy system (IES). However, renewable energy generation faces uncertainty; in addition, the IES lacks model representation. To solve this problem, this study proposes a carbon day-ahead optimal dispatch model for an integrated energy system with HPCWS and establishes carbon equations for conventional power generation and natural gas. The demand-side response of the IES is considered in conjunction with the objective functions of low-carbon operation and hydrogen storage gain maximization; furthermore, constraints are established to keep the dispatch results of the equipment within reasonable limits. Secondly, the scheduling model requires a faster and more accurate solution algorithm, so an improved particle swarm algorithm is proposed to solve the minimum of the objective function, and the superior convergence speed and accuracy of the algorithm are verified. The comparison of the IES before and after the introduction of HPCWS yields the changes in carbon emission values and hydrogen production before and after the optimization for the respective seasons and scenarios. In addition, the article also discusses the effect of season on the optimization results.- Book : 6(1)
- Pub. Date : 2025
- Page : pp.8-8
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2025
- Book : 233()
- Pub. Date : 2025
- Page : pp.116785-116785
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