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2025
Indonesia has the potential to develop floating wind turbines at sea. Therefore, its movement response needs to be analyzed to ensure that the turbine works properly. This research aims to determine the floating offshore wind turbine barge’s movement response with different floater shapes to regular waves from three different directions (0°, 45°, 90°). The movement response of the floating wind turbine was analyzed using the diffraction and radiation analysis methods in Ansys Aqwa. The research results include the RAO curve for the structure in a couple of two degrees of freedom (heave-pitch) combined with 2-dimensional analyses. The motion response of the floater cube has a maximum value heave motion 0.999 m/m and pitch motion 2.228 °/m, and, the cylindrical shape has a heave motion 1.132 m/m and pitch 10.050 °/m. Lastly, the octagonal has a heave motion 1.010 m/m and pitch 2.565 °/m. The shape and volume of each model affect the response value obtained. The simulation results in this paper can provide considerations in selecting the right floater shape to be used as a wind turbine floater foundation.- Book : 601()
- Pub. Date : 2025
- Page : pp.00084-00084
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2025
- Book : ()
- Pub. Date : 2025
- Page : pp.100153-100153
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2025
Our study aimed to assess air quality within buildings constructed with coal ash concrete, with a specific focus on radon measurement. Coal ash, a by-product of the TAQA Morocco thermal power plant. In this investigation, two concrete mixtures were prepared. It is possible that concrete produced from coal ash may contain elevated levels of radon, a naturally occurring radioactive gas that could prove detrimental to human health, given that coal ash contains considerable quantities of radioactive elements. To this regard, two nuclear techniques were employed for analysis: high-resolution gamma spectrometry and alpha dosimetry based on the use of LR115 on the two concrete mixes. The equivalent radium activity (Raeq), internal (Hin) and external (Hex) risk indices, absorbed dose rate (Ḋ), annual effective dose (Ė) and excess lifetime cancer risk (ELCR) were also calculated. The surface (ES) and mass (EM) radon exhalation rates were calculated for the analysed samples in order to assess the radiological risks resulting from the use of coal ash concrete.The results has revealed no evidence of any health risks to the general public, and therefore coal ash concrete can be used in construction projects.- Book : 601()
- Pub. Date : 2025
- Page : pp.00025-00025
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2025
Abstract
The circadian clock is an internal timekeeper system that regulates biological processes through a central circadian clock and peripheral clocks controlling various genes. Basic helix–loop–helix ARNT-like 1 (BMAL1), also known as aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL1), is a key component of the circadian clock. The deletion of BMAL1 alone can abolish the circadian rhythms of the human body. BMAL1 plays a critical role in immune cell function. Dysregulation of BMAL1 is linked to immune-related diseases such as autoimmune diseases, infectious diseases, and cancer, and vice versa. This review highlights the significant role of BMAL1 in governing immune cells, including their development, differentiation, migration, homing, metabolism, and effector functions. This study also explores how dysregulation of BMAL1 can have far-reaching implications and potentially contribute to the onset of immune-related diseases such as autoimmune diseases, infectious diseases, cancer, sepsis, and trauma. Furthermore, this review discusses treatments for immune-related diseases that target BMAL1 disorders. Understanding the impact of BMAL1 on immune function can provide insights into the pathogenesis of immune-related diseases and help in the development of more effective treatment strategies. Targeting BMAL1 has been demonstrated to achieve good efficacy in immune-related diseases, indicating its promising potential as a targetable therapeutic target in these diseases.- Book : 13()
- Pub. Date : 2025
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2025
- Book : ()
- Pub. Date : 2025
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2025
- Book : ()
- Pub. Date : 2025
- Page :
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2025
Background: Sodium butyrate (NaBu), a short-chain fatty acid, modulates global gene expression through histone deacetylase (HDAC) inhibition, suppressing proliferation and inducing apoptosis in various cancers. Rutin (RUT), a polyphenolic flavonoid found in many plants, exhibits notable anticancer properties. Combining chemotherapeutic agents with natural polyphenols represents a promising strategy for cancer therapy. This study aims to evaluate, for the first time, the potential effects of NaBu and RUT combination therapy on metastatic castration-resistant prostate cancer (mCRPC) cells. Methods: PC-3 cells were treated with varying concentrations of NaBu, RUT, and their combinations. Cell viability was assessed using the WST-1 assay. Based on combination index values, selected treatments were further analyzed for apoptosis (Annexin V assay), intracellular reactive oxygen species (ROS) production, mRNA expression levels, and changes in cell and nuclear morphology. Results: The combined treatment of NaBu and RUT significantly reduced cell viability compared to individual treatments. Enhanced apoptotic induction and elevated ROS levels were observed in combination-treated cells, alongside notable changes in cellular and nuclear morphology and mRNA expression levels. Conclusions: NaBu and RUT combination therapy exhibits a synergistic anticancer effect in mCRPC cells by inhibiting cell viability, inducing apoptosis, and increasing ROS production. These findings suggest a promising therapeutic approach that warrants further investigation to elucidate the underlying molecular mechanisms and assess its potential in preclinical and clinical settings.- Book : 13(2)
- Pub. Date : 2025
- Page : pp.296-296
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2025
Tests of nuclear weapons, routine and accidental releases of radionuclides from nuclear fuel cycle facilities, on one hand, and the long half-life decay time of 137Cs have led to significant levels of accumulation of this radioactive isotope in environmental objects in vast territories, which can have a negative impact on biota and public health. The search for effective methods to limit the transfer of radionuclides into food chains and remediate contaminated areas remains a pressing issue. One of the factors influencing the transfer of 137Cs from soil to plants is soil microbiom. The main hypothesis of this study is that developing arbuscular mycorrhizaon plant root systems leads to increasing the availability of cesium isotopes for root absorption and enhances their accumulation in underground and aboveground parts of plants. Therefore, the aim of this study was to determine the significance of arbuscular mycorrhiza in the root uptake of 137Cs from soil into a model plant.The vegetative experiment was conducted with barley variety Burshtyn chosen as a model plant. Mycorrhization of the root system was performed using the MycoApply SuperConcentrate inoculant. The results of the experiment allowed for the first time to demonstrate the relationship between accumulation and distribution parameters of 137Cs in barley plants with the level of arbuscular mycorrhiza development in the plant root system. Developing mycorrhizal infection in the barley root system increased the transfer factor of 137Cs from soil to the aboveground organs of barley 1.8–2.6 times compared to the control.At the same time, there is a tendency towards a decrease in the activity concentration of the radionuclide in the root system. - Book : 70(1)
- Pub. Date : 2025
- Page : pp.31-39
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2025
- Book : 128()
- Pub. Date : 2025
- Page : pp.107074-107074
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2025
Solvents are particularly hazardous among the mixture of pollutants found in the air, as their low vapor pressure allows them to reach the atmosphere, causing damage to ecosystems, and producing secondary deleterious effects on living organisms through a wide variety of possible reactions. In response, innovative, sustainable, and ecological methods are being developed to recover solvents from industrial wastewater, which is typically contaminated with other organic compounds. This study describes the procedure for recovering acetone from a residue from the pharmaceutical industry. This compound contains a high amount of solid organic compounds, which are generated during the manufacture of medicines. The treatment consisted of performing a simple solar distillation using a single-slope glass solar still, which separated the acetone from the mother solution. Under ideal circumstances, the use of solar radiation allowed an efficiency rate of 80% using solar concentration by means of mirrors to increase the temperature and 85% without the use of mirrors in the production of distilled acetone, which was characterized to evaluate its quality using instrumental analytical techniques: NMR, IR, and GC. The results obtained indicate that the acetone recovered by this procedure has a good quality of 84%; however, due to this percentage obtained, its reuse is limited for certain applications where a high degree of purity is required, such as its reuse for pharmaceutical use; for this reason, it was proposed to use said compound to eliminate the organic impurities contained in the catalyst waste granules used in a Mexican oil refinery. The resulting material was examined by SEM and EDS, revealing a high initial carbon content that decreased by 29% after treatment. Likewise, as an additional study, a study was carried out to evaluate the characteristics of the residues obtained at the end of the distillation where rubidium, silicon, carbon, nitrogen, oxygen, and chlorine contents were observed.- Book : 13(2)
- Pub. Date : 2025
- Page : pp.361-361
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