Objectives: The aim of this study was to compare the efficacy and safety of thermal ablation, focusing on radiofrequency ablation (RFA) and microwave ablation (MWA), for hepatocellular carcinoma (HCC) using US-, CT-, and MR-guidance. Methods: PubMed, EMBASE, Cochrane Library, and Web of Science were searched for studies comparing US, CT, and MR guidance in thermal ablation for HCC. Observational studies and randomized controlled trials (RCTs) were included. Overall survival (OS), local tumor recurrence (LTR), primary technique effectiveness (PTE), and major complications were assessed with network meta-analysis. Results: One RCT and 13 retrospective cohort studies reporting on 2349 patients were included. For OS at 3 years, compared to CT, US had hazard ratios (HRs) of 0.98 (95%CI: 0.77–1.26), and MR had HRs of 1.60 (95%CI: 0.51–5.00); For OS at 5 years, US had HRs of 0.80 (95%CI: 0.64–1.01), and MR had HRs of 1.23 (95%CI: 0.52–2.95) compared to CT. LTR rates, PTE, and major complications did not show statistical significance among the three guidance modalities (LTR: RR = 0.29 (95%CI: 0.08–1.14), p = 0.97 MR vs. CT; RR = 0.25 (95%CI: 0.06–1.02), p = 0.97 MR vs. US; PTE: RR = 1.06 (95%CI: 0.96–1.17), p = 0.90 MR vs. CT; RR = 1.08 (95%CI: 0.98–1.20), p = 0.90 MR vs. US. Major complications: RR = 0.27 (95%CI: 0.13–0.59), p = 0.94 MR vs. CT; RR = 0.41 (95%CI: 0.10–1.74), p = 0.94 MR vs. US). Conclusions: CT-, US-, and MR-guided RFA and MWA are equally effective and safe for HCC patients.

• Book : 17(3)
• Pub. Date : 2025
• Page : pp.409-409
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Recent results on the identified charged-hadron (π±, K±, p, p¯) production vat midrapidity region (|η| < 0.35) have been measured by the PHENIX experiment in p + Al, 3He + Au, Cu + Au collisions at √SNN = 200 GeV and U + U collisions at √SNN = 193 GeV. These measurements are presented through the invariant transverse-momentum (pT ) and transverse-mass (mT) spectra for different collision centralities. The averaged freeze-out temperature value for different systems was found to be 166.1 ± 2.2 MeV, and do not exhibit any dependence on the collision centrality and 〈Nparti〉 values. The particle ratios of K/π and p/π have been measured in different centrality ranges of large and small collision systems. The values of K/π ratios measured in all considered collision systems were found to be consistent with those measured in p+p collisions. Furthermore, the identified charged-hadron nuclear-modification factors (RAB) are also presented. Enhancement of proton RAB values over meson RAB values was observed in central 3He+Au, Cu+Au, and U+U collisions. The proton RAB values measured in p+Al collision system were found to be consistent with RAB values of ∅, π±, K±, and π0 mesons, suggesting that the size of the system produced in p+Al collisions is too small for recombination to cause a noticeable increase in proton production.

• Book : 316()
• Pub. Date : 2025
• Page : pp.03006-03006
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Hyperpolarized-13C magnetic resonance imaging (HP-13C MRI) was used to image changes in 13C-lactate signal during a visual stimulus condition in comparison to an eyes-closed control condition. Whole-brain 13C-pyruvate, 13C-lactate and 13C-bicarbonate production was imaged in healthy volunteers (N = 6, ages 24–33) for the two conditions using two separate hyperpolarized 13C-pyruvate injections. BOLD-fMRI scans were used to delineate regions of functional activation. 13C-metabolite signal was normalized by 13C-metabolite signal from the brainstem and the percentage change in 13C-metabolite signal conditions was calculated. A one-way Wilcoxon signed-rank test showed a significant increase in 13C-lactate in regions of activation when compared to the remainder of the brain ([Formula: see text]). No significant increase was observed in 13C-pyruvate signal ([Formula: see text]) or 13C-bicarbonate signal ([Formula: see text]). The results show an increase in 13C-lactate production in activated regions that is measurable with HP-13C MRI.

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• Pub. Date : 2025
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• Pub. Date : 2025
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The work is devoted to studying the composition for grain (barley and wheat) by terahertz (THz) high-resolution gas spectroscopy. The comparison of the set of chemical compounds formed during thermal decomposition of grain and cereals produced from grain was carried out with using a high-resolution spectrometer with phase-switching of radiation in the range of 115-175 GHz acting on studied gas developed by the authors. Free online spectroscopy databases were used for identification of substances. The results of comparison of molecular profiles of gas mixtures of thermal decomposition products of two varieties of barley, pearl barley and one variety of wheat are presented. Good agreement of the molecular composition for barley and pearl barley and some difference from the composition of the mixture obtained by heating wheat are shown.

• Book : 2025(1)
• Pub. Date : 2025
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• Pub. Date : 2025
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Abstract Background Cutaneous hypertrophic scar is a fibro-proliferative hard-curing disease. Recent studies have proved that antagonists of angiotensin II type 1 receptor (AT1R) and agonists of type 2 receptor (AT2R) were able to relieve hypertrophic scar. Therefore, establishing new methods to pursue dual-target lead compounds from Chinese herbs is in much demand for treating scar. Methods To this end, we immobilized AT1R or AT2R onto the surface of silica gel from cell lysates through a specific covalent bond by bioorthogonal chemistry. The columns containing immobilized AT1R or AT2R were jointly utilized to pursue potential bioactive compounds simultaneously binding to AT1R and AT2R from the extract of Rhei Radix et Rhizoma. Their functions on AT1R and AT2R expressions were investigated by in vitro and in vivo experiments. Results Aloe-emodin and emodin were identified as the potential bioactive compounds binding to both of the two receptors, thereby improving the appearance and pathomorphology of hypertrophic scar. They blocked the AT1R pathway to down-regulate the expression of transforming growth factor-β1 (TGF-β1) and stimulate matrix metalloproteinase-1 (MMP-1) expression. As such, the expression of collagen I/III reduced. Conversely, the bindings of the two compounds to AT2R reduced the production of nuclear factor-кB1 (NF-кB1), whereby the generation of interleukin-6 (IL-6) was blocked. Conclusion We reasoned that aloe-emodin and emodin had the potential to become dual-target candidates against hypertrophic scar through the regulation of AT1R and AT2R signaling pathways. It showed considerable potential to become a universal strategy for pursuing multi-target bioactive compounds from Chinese herbs by the utilization of diverse immobilized receptors in a desired order.

• Book : 20(1)
• Pub. Date : 2025
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Porcine circovirus type 2 (PCV2) is a significant pathogen responsible for porcine circovirus-associated diseases (PCVAD), and it is widely prevalent in pig farms, leading to huge economic losses for the pig industry. Currently, the ability of PCV2 to enhance its own replication by using the antiviral inflammatory factors IFNα, IFNβ, and IL-2 and its complex immune escape mechanism remain unclear, which has attracted wide attention. Research has indicated that GTPase-activating protein (SH3 domain)-binding protein 1 (G3BP1) is involved in the innate immune response to a variety of viruses, primarily by regulating and composing stress granules (SGs) to inhibit viral replication. Our initial studies identified elevated G3BP1 expression during PCV2 infection, paradoxically promoting PCV2 replication. In light of this phenomenon, this study aims to elucidate how PCV2 regulates G3BP1 to enhance its replication. Our findings demonstrate that G3BP1 overexpression further activates PCV2-induced expression of RIG-I, MDA5, cGAS and STING, thereby promoting IFNβ production and affecting cell cycle arrest in the S phase, facilitating PCV2 replication. Moreover, interactions were observed between PCV2 Cap protein and G3BP1’s RGG domain, and between PCV2 Rep protein and G3BP1’s NTF2 and RRM domains, potentially promoting viral protein nuclear transfer. In summary, PCV2 enhances its replication by modulating G3BP1 to induce IFNβ production and directly binds viral proteins to promote viral protein nuclear transfer. This research provides a foundation for further investigation into the immune evasion mechanisms of PCV2.

• Book : 26(3)
• Pub. Date : 2025
• Page : pp.1083-1083
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• Pub. Date : 2025
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• Pub. Date : 2025
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