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2025
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2025
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2025
ABSTRACTCitronellol (CT) is a naturally occurring lipophilic monoterpenoid which has shown anticancer effects in numerous cancerous cell lines. This study was, therefore, designed to examine CT's potential as an anticancer agent against glioblastoma (GBM). Network pharmacology analysis was employed to identify potential anticancer targets of CT. A comprehensive data mining was carried out to assess CT and GBM‐associated target genes. Protein–protein interaction network was constructed to identify hub genes and later GO and KEGG enrichment analysis was performed to elucidate the possible mechanism. Human glioblastoma cell line “SF767” was used to confirm in silico findings. MTT, crystal violet, and trypan blue assays were performed to assess the cytotoxic effects of various concentrations of CT. Subsequently, ELISA and qPCR were performed to analyze the effects of CT on proapoptotic and inflammatory mediators. In silico findings indicated that CT differentially regulated proapoptotic and inflammatory pathways by activating caspase‐3 and 8 and inhibiting nuclear factor‐kappa B (NF‐κB), tumor necrosis factor‐α, Janus kinase 2 (JAK2). Molecular docking also demonstrated strong binding affinities of CT with the above‐mentioned mediators when compared to 5‐fluorouracil or temozolomide. In SF767 cell line, CT displayed dose‐dependent cytotoxic and antioxidant effects, and upregulation of annexin‐V, caspase‐3, and 8 along with downregulation of inflammatory modulators. In a nutshell, it can be concluded from these findings that CT possesses robust anticancer activity which is mediated via differential regulation of caspase‐3, JAK2, and NF‐κB pathways.- Book : 13(1)
- Pub. Date : 2025
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2025
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2025
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2025
The article provides a comparative analysis of the current practice of Russian organisations in the development and implementation of a balanced score-card. The reasons for low efficiency of the companies are described separately. The expediency of using a strategic management mechanism in the activities of the companies is substantiated in detail, and also, based on the application of tabular data, the scale of scientific research in the field of key performance indicators is indicated. The recommendations formulated by the authors reflect cause-and-effect relationships between customer requests and the needs of suppliers of goods and services. Particular attention is paid to assessing the potential effect of introducing the balanced scorecard into the activities of the Russian companies. As the article is written, patterns are revealed in the processes of implementation of personnel policies by the objects of research, formation of strategic goals, and realisation of a mechanism for disseminating information about the declared strategy among all official levels of the company. The authors of this work state detailed conclusions for each section indicating the detected motives for actions and predicting potential results. The algorithm for formulating recommendations for the development and implementation of the balanced scorecard identified at the beginning of the article finds its step-by-step development within the framework of the ongoing research and is accompanied by reasoned comments based both on previously published sources of information and on provisions proposed by the authors.- Book : (11)
- Pub. Date : 2025
- Page : pp.120-130
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2025
Abstract
The study of hybrid nanofluids is significant in thermal management applications by optimizing heat transfer through pioneering materials, mainly the flow of sodium alginate-based hybrid nanofluids. This work addresses the demand for effective cooling solutions in a variety of industrial processes and uses the unique characteristics of non-Newtonian fluids and their inferences for rheological modeling and heat transform enhancement. Inspired by the progressive properties of the non-Newtonian Casson fluid and its applied significance in the rheological modeling and heat transfer characteristics of different dynamic fluids, there is limited knowledge of their response in the mixed convective flow, particularly when influenced by factors like thermal radiation, joule heating, and thermal relaxation time. The present study aims to investigate the heat transfer enhancement of the mixed convective flow of a sodium alginate-based hybrid nanofluid on an extending sheet concentrating on the interaction of different physical parameters that affect thermal performance. The physical phenomena are modeled in a nonlinear partial differential equation, which is then converted into ordinary differential equations with the help of suitable similarity variables. Tables and figures are constructed to show the behavior of the physical parameters involved in the momentum and temperature equations. Premilinary assumptions applied to the flow are electrically conducting, rotating, dissipative, and thermal boundary conditions. A semi-analytical approach homotopy analysis method is employed to obtain the solution of the problem. The outcome witnessed that the velocity profiles show a diminishing behavior through a magnetic parameter; however, the temperature profile shows an escalating behavior. Similarly, the thermal plot intensifies with the Eckert number and thermal radiation. In addition, the numerical data from the tables portrayed that the skin friction decreases with the Casson parameter and the rotation parameter; however, an improvement behavior is noticed in the Nusselt number through thermal radiation and thermal Biot number. From the numerical data, it is concluded that the hybrid nanofluid has superior heat transfer characteristics compared to nanofluid. The finding of this result has also been compared with available results in the literature through a comparative study.- Book : 14(1)
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2025
Study Design Systematic review. Objective In patients with extradural metastatic spine disease, we sought to systematically review the outcomes and complications of patients with intermediate Spinal Instability Neoplastic Score (SINS) lesions undergoing radiation therapy, percutaneous interventions, minimally invasive surgeries, or open spinal surgeries. Methods Following PRISMA guidelines for systematic reviews, MEDLINE, EMBASE, Web of Science, the Cochrane Database of Systematic Reviews and the Cochrane Center Register of Controlled Trials were queried for studies that reported on SINS intermediate patients who underwent: 1) radiotherapy, 2) percutaneous intervention, 3) minimally invasive, or 4) open surgery. Dates of publication were between 2013-22. Patients with low- or high-grade SINS were excluded. Outcome measures were pain score, functional status, neurological outcome, ambulation, survival, and perioperative complications. Results Thirty-nine studies (n = 4554) were included that analyzed outcomes in the SINS intermediate cohort. Radiotherapy appeared to provide temporary improvement in pain score; however, recurrent pain led to surgery in 15%–20% of patients. Percutaneous vertebral augmentation provided improvement in pain. Minimally invasive surgery and open surgery offered improvement in pain, quality of life, neurological, and ambulatory outcomes. Open surgery may be associated with more complications. There was limited evidence for radiofrequency ablation. Conclusion In the SINS intermediate group, radiotherapy was associated with temporary improvement of pain but may require subsequent surgery. Both minimally invasive surgery and open spinal surgery achieved improvements in pain, quality of life, and neurological outcomes for patients with spine metastases. Open surgery may be associated with more complications. - Book : 15(1_suppl)
- Pub. Date : 2025
- Page : pp.132S-142S
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2025
- Book : 13()
- Pub. Date : 2025
- Page : pp.101088-101088
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2025
Study Design Narrative Review. Objective The management of spinal tumors requires a multi-disciplinary approach including surgery, radiation, and systemic therapy. Surgical approaches typically require posterior segmental instrumentation to maintain long-term spinal stability. Carbon fiber reinforced pedicle screws (CFRP) are increasingly used in the oncologic setting due to reductions in both imaging artifacts and radiotherapy perturbations compared to titanium implants. We performed a review of the literature and highlight advantages and future areas of study for CFRP. Methods We performed a systematic review of the literature using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines and identified 10 articles including 573 patients. Across all studies we reviewed patient demographics, tumor types treated, hardware-related features, complication rates, recurrence, survival, and follow-up. Results Across 10 studies, a total of 1371 screws placed. Surgical and non-surgical complications were reported in 18.3% of patients. Disease progression at the surgical site was detected in 7.3% of patients. There was no significant difference in clinical or hardware complications between CFRP or titanium implants. The most frequent complication attributable to implanted CFRP hardware included screw breakage in 2.4% and loosening in 1.7% of patients, respectively. Conclusion CFRP provide a unique tool in the setting of spinal oncology. With a safety profile comparable to titanium, we review the documented advantages of CFRP posterior implants compared to titanium, while also addressing their current limitations. Additionally, we highlight several areas of future research to identify the optimal patients who will achieve the greatest benefit of CFRP. - Book : 15(1_suppl)
- Pub. Date : 2025
- Page : pp.157S-165S
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