| 764388 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
760 In vivo demethylation-mediated reversal of tumor cell-intrinsic cGAS silencing improves the efficacy of STING agonist therapy |
2021-11-01 |
10.1136/jitc-2021-sitc2021.760 |
Falahat Rana, Perez-Villarroel Patricio, Berglund Anders, Pilon-Thomas Shari, Barber Glen, Mule James |
| 764387 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
759 Single-Cell Proteogenomics (Cite-seq) analysis of cGAS-STING pathway activation alone and in combination with nivolumab using a patient-derived 3D ex vivo tumoroid platform |
2021-11-01 |
10.1136/jitc-2021-sitc2021.759 |
Bunch Brittany, Joerger Autumn, Mtchedlidze Nino, Hoff Olivia, Guzman Kelly, Ehrhart Jared, Altiok Soner |
| 764386 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
326 The anti-TIGIT antibody M6223 induces significant anti-tumor efficacy and immune response via multiple mechanisms of action |
2021-11-01 |
10.1136/jitc-2021-sitc2021.326 |
Xu Chunxiao, Jiang Feng, Huang Hui, Webb Lindsay, Yalavarthi Sireesha, Bourin Clotilde, Wang Hong, Belousova Natalya, Chen Zhouxiang, Kelton Christie, Zhang Dong, Halle Joern-Peter, Blaukat Andree, Moisan Jacques |
| 764385 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
758 High-potency synthetic STING agonists rewire the myeloid stroma in the tumour microenvironment to amplify immune checkpoint blockade efficacy in refractory pancreatic ductal adenocarcinoma |
2021-11-01 |
10.1136/jitc-2021-sitc2021.758 |
Boda Akash, Ager Casey, Rajapakshe Kimal, Lea Spencer, Francesco Maria Emilia Di, Jones Philip, Curran Michael |
| 764384 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
757 M9657, a novel tumor-targeted conditional anti-CD137 agonist displays MSLN-dependent anti-tumor immunity |
2021-11-01 |
10.1136/jitc-2021-sitc2021.757 |
Xu Chunxiao, Rabinovich Brain, Deshpande Amit, Zhou Xueyuan, Pipp Frederic Christian, Schweickhardt Rene, Webb Lindsay, Yalavarthi Sireesha, Bourin Clotilde, Ghatak Payel, Safi Barroq, Wollerton Francisca, Brewis Neil, Munoz-Olaya Jose, Belousova Natalya, Alimzhanov Marat, Hubensack Martina, Halle Joern-Peter, Blaukat Andree, Moisan Jacques |
| 764383 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
604 Combining a novel dual RAF/MEK inhibitor with immunomodulation to promote an anti-tumor response |
2021-11-01 |
10.1136/jitc-2021-sitc2021.604 |
Dong Lauren, Choi Hyejin, Budhu Sadna, Schulze Isabell, Mehanna Nezar, Rosen Neal, Merghoub Taha, Wolchok Jedd |
| 764382 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
603 Targeted STAT3 degradation leads to remodeling of an immunosuppressive tumor microenvironment and subsequent sensitization to immune checkpoint therapy |
2021-11-01 |
10.1136/jitc-2021-sitc2021.603 |
Dey Joyoti, Liu Phillip, Mayo Michele, Karnik Rahul, Yang Bin, Dixit Vaishali, Jeong Jieun, Gollob Jared, Savi Chris De |
| 764381 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
601 Sequencing immunotherapy before lymphatic ablation unleashes cDC1-dependent antitumor immunity in HNSCC |
2021-11-01 |
10.1136/jitc-2021-sitc2021.601 |
Saddawi-Konefka Robert, O’Farrell Aoife, Faraji Farhoud, Allevato Michael, Wang Zhiyong, Wu Victoria, Yung Bryan, Anang Nana-Ama, Franiak-Pietryga Ida, Simon Aaron, Jensen Shawn, Fox Bernard, Sharabi Andrew, Cohen Ezra, Califano Joseph, Silvio Gutkind J |
| 764380 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
600 BR101801 stimulates anti-tumor immunity and enhances the efficacy of radiation in a syngeneic model |
2021-11-01 |
10.1136/jitc-2021-sitc2021.600 |
Wang Seungho, Yoon Yi Na, Son Mi kwon, Kim Soo Jung, Lee Bo Ram, Yang Eun hee, Jeon Byeongwook, Lee Seung Hyun, Kim Tae-Jin, Kim Jae-Sung, Lee Joo Han |
| 764379 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
598 Local radiation in combination with CpG and anti-OX40 induces enhanced T cell activation and proliferation |
2021-11-01 |
10.1136/jitc-2021-sitc2021.598 |
Spiegelman Dan, Pieper Alexander, Zangl Luke, Feils Arika, Hoefges Anna, Felder Mildred, Moram Sritha, Rakhmilevich Alexander, Erbe Amy, Hank Jacquelyn, Patel Ravi, Morris Zachary, Sondel Paul |
