| 764428 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
769 A single dose of intratumoral TransCon™ TLR7/8 agonist monotherapy promoted sustained activation of antigen presenting cells resulting in CD4+ and CD8+ T cell activation and tumor growth inhibition |
2021-11-01 |
10.1136/jitc-2021-sitc2021.769 |
Zuniga Luis, Uppal Karan, Bang Kathy, Hong Enping, Sabharwal Simran, Lee Yuchi, Martinez Solomon, Rosen David, Mirza Amer, Punnonen Juha |
| 764427 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
768 Systemic delivery of a tumor-targeted TLR9 agonist conjugate transforms the tumor immune landscape and induces tumor regression in mice |
2021-11-01 |
10.1136/jitc-2021-sitc2021.768 |
Candidate Caitlyn Miller, Sagiv-Barfi Idit, Neuhoefer Patrick, Czerwinski Debra, Artandi Steven, Bertozzi Carolyn, Levy Ronald, Cochran Jennifer |
| 764426 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
767 Activation of CD8+ T cells in the presence of multiple TLR agonists affects the expression of T-cell checkpoint receptors via IL-12 and type-1 interferon |
2021-11-01 |
10.1136/jitc-2021-sitc2021.767 |
Jeon Donghwan, McNeel Douglas |
| 764425 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
766 Toward safe, systemic delivery of synthetic TLR7/8 agonists using Bottlebrush Prodrugs (BPDs) |
2021-11-01 |
10.1136/jitc-2021-sitc2021.766 |
Bhagchandani Sachin, Milling Lauren, Liu Bin, Fessenden Timothy, Spranger Stefani, Johnson Jeremiah, Irvine Darrell |
| 764424 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
616 CD47 blockade modulates immunosuppressive checkpoint molecules and cellular metabolism to sensitize triple-negative breast cancer tumors to immune checkpoint blockade therapy |
2021-11-01 |
10.1136/jitc-2021-sitc2021.616 |
Stirling Elizabeth, Wilson Adam, Cook Katherine, Thomas Alexandra, Triozzi Pierre, Soto-Pantoja David |
| 764423 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
615 Reactivating antitumor immunity in gliomas with osteopontin/integrin blocking peptide |
2021-11-01 |
10.1136/jitc-2021-sitc2021.615 |
Pilanc-Kudlek Paulina, Poleszak Katarzyna, Ellert-Miklaszewska Aleksandra, Canalda Adria-Jaume Roura, Cyranowski Salwador, Swatler Julian, Gielniewski Bartłomiej, Kamińska Bożena |
| 764422 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
614 Investigating immune mediated mechanisms of PARPi resistance in BRCA1-associated triple negative breast cancer (TNBC) |
2021-11-01 |
10.1136/jitc-2021-sitc2021.614 |
Mehta Anita, Townsend Madeline, Oliwa Madisson, Lee Patrice, Saccomano Nicholas, Lynce Filipa, Shapiro Geoffrey, Mittendorf Elizabeth, Guerriero Jennifer |
| 764421 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
612 Human ribonucleases act as potential plasma biomarkers for targeted therapy and immunotherapy in hepatocellular carcinoma |
2021-11-01 |
10.1136/jitc-2021-sitc2021.612 |
Zha Zhengyu, Zhou Chenhao, Yu Dihua, Hung Mien-Chie, Liu Chunxiao, Ren Ning |
| 764420 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
611 Exploiting T cells as vehicles of liposomal SHP2i to enhance adoptive cell therapy |
2021-11-01 |
10.1136/jitc-2021-sitc2021.611 |
Li Xin, Halldórsdóttir Hólmfridur, Weller Sven, Colliander Anna, Jæhger Ditte, Bak Martin, Clergeaud Gael, Andresen Thomas |
| 764419 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
609 Combining bintrafusp alfa with abituzumab enhances suppression of the TGF-β signaling pathway |
2021-11-01 |
10.1136/jitc-2021-sitc2021.609 |
Jiang Feng, Wang Hong, Yeung Tsz-Lun, Qin Guozhong, Marelli Bo, Huang Hui, Lo Kin-Ming, Lan Yan |
