| 764198 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
704 The computationally designed human antibody, AU-007, mediates human immune activation by endogenous IL-2, while uniquely breaking the IL-2 auto-inhibitory loop and preventing Treg expansion |
2021-11-01 |
10.1136/jitc-2021-sitc2021.704 |
Amit Inbar, Levin Itay, Wyant Timothy, Levitan Natali, Barak Reut, Ben-Mayor May, Bluvshtein Olga, Grossman Noam, Sasson Yehezkel, Nimrod Guy, Zehnin Michael, Fischman Sharon, Štrajbl Marek, Danielpur Liron, Knickerbocker Aron, Vasselli James, Ofran Yanay |
| 764197 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
746 Vectorized Treg-depleting anti-CTLA-4 elicits antigen cross-presentation and CD8+ T cell immunity to reject “cold” tumors |
2021-11-01 |
10.1136/jitc-2021-sitc2021.746 |
Semmrich Monika, Marchand Jean-Baptiste, Rehn Matilda, Fend Laetitia, Remy-Ziller Christelle, Holmkvist Petra, Silvestre Nathalie, Svensson Carolin, Kleinpeter Patricia, Deforges Jules, Junghus Fred, Martensson Linda, Foloppe Johann, Teige Ingrid, Quemeneur Eric, Frendeus Bjorn |
| 764196 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
545 A phase 2 study of retifanlimab in patients with advanced or metastatic merkel cell carcinoma (MCC) (POD1UM-201) |
2021-11-01 |
10.1136/jitc-2021-sitc2021.545 |
Grignani Giovanni, Rutkowski Piotr, Lebbe Celeste, Prinzi Natalie, Grob Jean-jaques, Tanda Enrica Teresa, Guida Michele, Burgess Melissa, Pulini Jennifer, Shankar Sadhna, Tian Chuan, Bhatia Shailender |
| 764195 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
544 DELTA-1: A global, multicenter phase 2 study of ITIL-168, an unrestricted autologous tumor-infiltrating lymphocyte (TIL) cell therapy, in adult patients with advanced cutaneous melanoma |
2021-11-01 |
10.1136/jitc-2021-sitc2021.544 |
Gastman Brian, Hamid Omid, Corrie Pippa, Gibney Geoffrey, Daniels Gregory, Chmielowski Bartosz, Thomas Sajeve, Domingo-Musibay Evidio, Lawrence Donald, Jiang Yizhou, Kennedy Audrey, Aycock Jeff, Alvarez-Rodriguez Ruben, Robbins Paul, Gall John Le, Roberts Zachary, Hawkins Robert, Sarnaik Amod |
| 764194 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
543 Sensitive quantification and tracking of the active components of a Clonal Neoantigen T cell (cNeT) therapy: From manufacture to peripheral circulation |
2021-11-01 |
10.1136/jitc-2021-sitc2021.543 |
Turajlic Samra, Jamal-Hanjani Mariam, Furness Andrew, Plummer Ruth, Cave Judith, Thistlethwaite Fiona, Leire Emma, Middleton Jen, Williams Eloise, Baker Amy, Maine Chloe, Epstein Michael, Sassi Monica, Newton Katy, Grant Michael, Saggese Matilde, Quezada Sergio, Forster Martin |
| 764193 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
542 Randomized trial of tumor lysate particle only vaccine vs. tumor lysate particle-loaded, dendritic cell vaccine to prevent recurrence of resected stage III/IV melanoma: 36-month analysis |
2021-11-01 |
10.1136/jitc-2021-sitc2021.542 |
Carpenter Elizabth, Adams Lexy, Chick Robert, Clifton Guy, Vreeland Timothy, Valdera Franklin, McCarthy Patrick, O’Shea Anne, Hale Diane, Bohan Phillip Kemp, Hickeron Annelies, Myers John, Cindass Jessica, Hyngstrom John, Berger Adam, Sussman Jeffrey, Jakub James, Shaheen Montaser, Yu Xianzhong, Wagner Thomas, Faries Mark, Peoples George |
| 764192 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
540 Baseline mTOR transcriptional signatures in CD8 T cells are associated with immune-related adverse events but not anti-tumor responses in patients receiving immune checkpoint inhibitors |
2021-11-01 |
10.1136/jitc-2021-sitc2021.540 |
Zhao Chen, Mule Matthew, Martins Andrew, Fernandez Iago Pinal, Donahue Renee, Chen Jinguo, Schlom Jeffrey, Gulley James, Mammen Andrew, Tsang John, Rajan Arun |
| 764191 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
539 Phase 1 study of mRNA-2752, a lipid nanoparticle encapsulating mRNAs encoding human OX40L/IL-23/IL-36γ, for intratumoral (ITu) injection +/- durvalumab in advanced solid tumors and lymphoma |
2021-11-01 |
10.1136/jitc-2021-sitc2021.539 |
Patel Manish, Jimeno Antonio, Wang Ding, Stemmer Salomon, Bauer Todd, Sweis Randy, Geva Ravit, Kummar Shivaani, Reagan Patrick, Perets Ruth, LoRusso Patricia, Gupta Shilpa, Zacharek Sima, Laino Andressa, Milberg Oleg, Frederick Josh, Chen Sheryl, Pascarella Stephanie, Randolph William, Aanur Praveen, Johansen Lisa, Do Khanh, Meehan Robert, Sullivan Ryan |
| 764190 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
191 GAPDH knock-in of high affinity CD16 in iPSC derived NK cells drives high-level expression and increased anti-tumor function |
2021-11-01 |
10.1136/jitc-2021-sitc2021.191 |
Pattali Rithu, Izzo Kaitlyn, Goncz Edward, Sexton Steven, Wasko Kevin, Zuris John, Nehil Michael, Zhang Kate, Shearman Mark, Chang Kai-Hsin, Allen Alexander |
| 764189 |
JOURNAL FOR IMMUNOTHERAPY OF CANCER |
188 Development of WU-NK-101, a feeder cell-free expanded allogeneic memory NK cell product with potent anti-tumor activity |
2021-11-01 |
10.1136/jitc-2021-sitc2021.188 |
Sullivan Ryan, Mathyer Mary, Govero Jennifer, Dean John, Martens Andrew, Zhou You, Darwech Malik, Tumala Brunda, Vessoni Alex, Hamil Alexander, Leedom Tom, Johnson Corey, Berrien-Elliot Melissa, Foster Mark, Becker-Hapak Michelle, McClain Ethan, Neal Carly, Fehniger Todd, Shrestha Niraj, Dee Mike, Wong Hing, Kabakibi Ayman, Cooper Matthew, Chrobak Ken |
