□ 연구개발 목표 및 내용 ○ 최종 목표 Development of bio- and engineered-textiles by multilayered nanomaterials to provide the microenvironment for the treatment of skin cancer and filtering of radiations (ultraviolet (UV) & electromagnetic (EM)) to prevent onset and growth of cancer. ○ 전체 내용 Main description of goals: ● Synthesis of multi-layered nanomaterials on textile fabric suitable for microenvironment with UV protection and EM shielding ● Analysis of the prepared textiles for functional properties toward the textile characteristics and desired applications ● In-vitro studies on modified textiles with normal and skin cancer cells ● Development of bio-engineered textiles with the capability of cancer cell apoptosis and radiation filter In this project, we intend to design bio-cum-engineering textiles modified with nanomaterials of suitable characteristics of UV protection, EM shielding, and cytotoxicity toward skin cancer cells. ○ 1단계 ● 목표 Development of biocompatible nanomaterials to attach on textiles cloth for proliferation of skin cells. ● 내용 To achieve this goal, I have chosen gold nanoparticles (AuNPs) as they are considered the most suitable materials for drug delivery, and their hot electrons are non-active in the UV zone. Consequently, I optimized the preparation of AuNPs using various methodologies and surfactants to enhance their ability to promote the proliferation of skin cells and load drug molecules. In the first year, I developed AuNPs using two different strategies for cell proliferation and drug delivery: 1. 60 nm AuNPs were prepared using a novel, sustainable, and green technique capable of loading drug molecules and promoting the proliferation of skin cells. 2. 50 nm AuNPs were prepared using the standard Turkevich protocol without any additional surfactant modifications. The prepared AuNPs were subjected to standard procedures to evaluate their effectiveness in promoting the proliferation of skin cells: 1. L929 cells were tested with textile samples modified with AuNPs. 2. MTT assay was performed to assess the proliferation capability or toxicity of cells on the textile surface. The results confirmed that both types of AuNPs promoted cell proliferation, but the citrate-capped AuNPs showed higher proliferation. ○ 2단계 ● 목표 Textile cloth modified with nanomaterials to filter the radiation ● 내용 To achieve this, I have chosen zinc oxide (ZnO) nanomaterials as they are effective UV filters and widely utilized in radiation filters. To identify the most suitable ZnO nanomaterials, I prepared them to use the following methods: 1. ZnO was prepared using different Zn binders such as chloride, nitrate, sulfate, and acetate. 2. ZnO was synthesized using different surfactants like HMTA (hexamethylenetetramine). These methods resulted in the formation of various nanostructures including particles, nanopillars, nanorods, and nanodisks. Among these structures, the nanopillars made of ZnO exhibited a radiation filter capability. □ 연구개발성과 ● Biocompatible cotton textile cloth material: It can promote the proliferation of skin cells for various applications, such as intuitive wound healing, skin cancer treatment, and biocompatible intralayer for wearables. ● Selective improvement in the narrow band radiation filter. ● Identification of active methodologies for textile treatment. □ 연구개발성과 활용계획 및 기대 효과 The developed AuNPs have shown significant potential as an internal wound healing agent, without negatively affecting the skin's physiological mechanisms. Furthermore, they have the capability to efficiently load drugs to support other skin tissues. The AuNPs-modified textile cloth, as a wearable, effectively nourishes our skin cells through proliferation. Expected effect： The transfer of this strategy to the scale-up process is projected to secure a position in the future million-dollar market (estimated to reach US$249.95 billion by 2026). In the healthcare industry, bio-functional textiles will hold great importance as stable and reusable medical clothing. Given the drastic changes and imbalances in climate conditions, the adoption of bio-functional textiles as a protective layer against harmful radiation and skin cancer in our daily lives becomes imperative. (source : 요약문 3p)
- 연구책임자 : SHANKAR PRABAKARAN
- 주관연구기관 : 성균관대학교
- 발행년도 : 20230600
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