Disclosed in the present invention are crystal forms of a nitrogen-containing spiro compound, a preparation method therefor and the use thereof. Provided in the present invention is a crystal form I of a nitrogen-containing spiro compound as shown in formula A, which crystal form I has an X-ray powder diffraction pattern comprising diffraction peaks at 5.67±0.20°, 11.37±0.20°, 16.69±0.20°, 17.32±0.20° and 19.73±0.20° 2θ, as determined by using Cu-Kα radiation. Provided in the present invention is a crystal form II of the nitrogen-containing spiro compound as shown in formula A, which crystal form II has an X-ray powder diffraction pattern comprising diffraction peaks at 11.32±0.20°, 11.70±0.20°, 11.93±0.20°, 18.03±0.20°, 18.81±0.20° and 19.17±0.20° 2θ, as determined by using Cu-Kα radiation. The crystal forms of the nitrogen-containing spiro compound of the present invention have good stability, an inhibitory activity on complement factor D, a good inhibitory effect on rabbit erythrocyte hemolysis, and relatively high in-vivo exposure and relatively high oral bioavailability.
- 출원번호 : CN2024/084387
- 출원인 : WUHAN CREATERNA SCIENCE AND TECHNOLOGY CO., LTD.
- 특허번호 :
- IPC : C07D-221/20(2006.01);C07D-471/10(2006.01);C07D-209/54(2006.01);C07C-069/734(2006.01);A61P-007/00(2006.01);A61P-009/00(2006.01);A61P-037/02(2006.01);A61P-025/28(2006.01);A61P-011/00(2006.01);A61P-013/00(2006.01);A61P-013/12(2006.01);A61P-027/02(2006.01);A61P-029/00(2006.01);A61P-019/02(2006.01);A61P-017/06(2006.01);A61P-021/04(2006.01);A61P-031/14(2006.01);A61K-031/438(2006.01);A61K-031/395(2006.01);