PROBLEM TO BE SOLVED: To provide newly improved treatment of liver cancers, in particular hepatocellular carcinoma.SOLUTION: The disclosure relates to compositions and methods for treating liver cancer, in particular, hepatocellular carcinoma using an antisense (AS) nucleic acid against an insulin-like growth factor 1 receptor (IGF-1R). The AS allows for systemic administration to the patient or is used for producing an autologous cancer cell vaccine. In embodiments, the AS is provided in an implantable irradiated biodiffusion chamber comprising tumor cells and an effective amount of the AS. The chambers are irradiated with radiation and implanted in the abdomen of the subject and stimulate an immune response that attacks tumors distally. The compositions and methods disclosed herein may be used to treat many different kinds of liver cancer.SELECTED DRAWING: Figure 1A

• 출원번호 : 2024127685
• 출원인 : UNIV THOMAS JEFFERSON
• 특허번호 :
• IPC : C12N-005/10(2006.01);C12N-015/113(2010.01);

The present disclosure relates to the identification of gene signature panels and tumor characteristics for predicting solid tumors (e.g., lung cancer) response to immune checkpoint blockade and/or radiation therapy, and methods of uses thereof.

• 출원번호 : US2024/040687
• 출원인 : CORNELL UNIVERSITY
• 특허번호 :
• IPC : C12Q-001/6886(2018.01)

The invention relates to a stroboscopic light-emitting device (1) for locating purposes, comprising a housing (10) provided with an infrared light emitter (20), a stabilised power supply module (40) contained in the housing and coupled to an electric accumulator (50), and a control module (30) also contained in the housing (10) and capable of controlling the duration and frequency of emission of the emitter (20) so as to generate a strobe light signal, characterised in that the light emitter consists of an infrared thermal emitter (20) comprising a heating element (21) through which an electric current is able to flow such that it causes the heating of the element and the emission of infrared thermal radiation.

• 출원번호 : EP2024/072058
• 출원인 : ACTION COMMUNICATION
• 특허번호 :
• IPC : G08B-005/00(2006.01);G08B-005/38(2006.01);F21L-004/00(2006.01);

A fuel element (1) for a nuclear reactor comprises a box structure (3), containing fuel bars (10), and at least one foot (2) and one head (5) positioned at respective opposite longitudinal ends of the box structure (3); the foot (2) being provided with at least one opening (2b) to allow in use reactor core cooling fluid to enter inside the box structure (3); the foot (2) is provided with a shutter member (30) cooperating with a peripheral edge (37b) of the opening (2b) to selectively open and close the opening (2b), so as to allow circulation of cooling fluid within the box structure (3) during reactor operation, and to prevent circulation of cooling fluid and keep the box structure (3) filled with cooling fluid during and after extraction of the fuel element from the reactor core, even in gas environment.

• 출원번호 : IB2024/057505
• 출원인 : NEWCLEO S.R.L.
• 특허번호 :
• IPC : G21C-003/322(2006.01);G21C-015/18(2006.01);G21C-015/28(2006.01);

An apparatus comprises an electronic component comprising at least one circuit, a shielding material, coupled to the electronic component, forming a protective shield over or partially surrounding said at least one circuit. The protective shield comprises one or more layers formed of a composite material. At least one layer of said is disposed on the electronic component to form the protective shield protecting the electronic component from radiation. The composite material comprises a polymer composite comprising an arrangement of carbon material to increase the emissivity of the composite material, and/or a thermal conductive coating disposed over said at least one layer facing toward the electronic component and/or a thermal reflective coating disposed over said at least one layer facing away from the electronic component.

• 출원번호 : US2024/040790
• 출원인 : COSMIC SHIELDING CORPORATION;SIHVER, Lembit;BARGHOUTY, Fakhri, Yanni;
• 특허번호 :
• IPC : H05K-009/00(2006.01)

The present invention relates to a screen (1) made of radioprotective material(s) for protecting an operator against emissions of ionising radiation such as X-rays or others, the screen comprising a rear face of the screen (2) facing which the operator is intended to be positioned, and a front face of the screen (3) opposite the rear face of the screen (2). According to the invention, this screen (1) comprises means (17, 17a) for generating a luminous marking (18, 18a) on the ground, suitable for delimiting a zone (C) considered to be a protective zone on the side of the rear face of the screen (2).

• 출원번호 : EP2024/072036
• 출원인 : LEMER PAX
• 특허번호 :
• IPC : A61B-006/10(2006.01)

The invention provides methods of using chloroplast-selectable markers to detect nuclear genome editing. The methods involve selecting a genetic modification that has occurred in a nuclear genome of a photosynthetic cell; transforming a photosynthetic cell with a ribonucleoprotein complex that effects a genetic modification in the genome in the nucleus of a photosynthetic cell; transforming the photosynthetic cell with a construct that effects an insertion of a selectable marker into the plastome of a plastid of the cell; selecting for photosynthetic cells having the selectable marker inserted into the plastome; and thereby selecting for the genetic modification to the genome in the nucleus of the photosynthetic cell.

• 출원번호 : US2024/040732
• 출원인 : VIRIDOS, INC.
• 특허번호 :
• IPC : C12N-015/64(2006.01);C12N-015/87(2006.01);C12N-015/63(2006.01);C12N-015/65(2006.01);C12N-015/66(2006.01);C12N-015/82(2006.01);

The present invention addresses the problem of providing: a radiation-sensitive composition and a pattern formation method with which it is possible to achieve sufficient levels of sensitivity, development contrast, development residue suppression property, and limit resolution property during formation of a pattern; and a polymer which can be used suitably for the radiation-sensitive composition. The radiation-sensitive composition contains: a polymer (A) containing a structural unit that has an acid-dissociable group, a structural unit that has a first organic acid anion (b1) and a first onium cation (c1) and includes a first acid-generating structure capable of generating, when exposed, an acid that induces the dissociation of the acid-dissociable group, and a structural unit that has a second organic acid anion (b2) and a second onium cation (c2) and includes a second acid-generating structure capable of generating, when exposed, an acid that does not induce the dissociation of the acid-dissociable group; and a solvent (B). The polymer (A) includes a partial structure represented by formula (i). (In formula (i), Ar represents a 5- to 20-membered aromatic ring having a valency of (m1 + m2 + m3 +1); X represents a hydroxy group, a carboxy group, a sulfonic acid group, or a mercapto group, wherein, when there are a plurality of X's, the plurality of X's are the same as or different from each other; R represents an acid-dissociable group or a non-acid-dissociable group, wherein, when there is one R, the R represents an acid-dissociable group, and when there are a plurality of R's, at least one of the plurality of R's represents an acid-dissociable group, and when there are a plurality of R's, the plurality of R's are the same as or different from each other; R represents a halogen atom, a cyano group, a nitro group, or a monovalent organic group (excluding -COOR), wherein, when there are a plurality of R's, the plurality of R's are the same as or different from each other; m1 represents an integer of 1-5, m2 represents an integer of 0-5, and m3 represents an integer of 0-6, wherein 2 ≤ m1 + m2; and "*" represents a bond to another structure in the polymer (A).)

• 출원번호 : JP2024/027546
• 출원인 : JSR CORPORATION
• 특허번호 :
• IPC : G03F-007/004(2006.01);C08F-212/14(2006.01);C08F-220/10(2006.01);G03F-007/20(2006.01);G03F-007/039(2006.01);

A circuit for testing power source conduction of a plasma ball lamp. The circuit is connected to an alternating-current output end of an external power source; and the circuit comprises a rectifying circuit (1) and a switch power source (2), wherein one end of the rectifying circuit (1) is connected to the alternating-current output end of the external power source, and the other end thereof is connected to the switch power source (2); the rectifying circuit (1) is used for converting an alternating current, which is output by the alternating-current output end, into a direct current and outputting the direct current to the switch power source (2); and the rectifying circuit (1) comprises at least two diodes and a substrate, each diode being integrated on the substrate. The present application has the effects of being high in terms of integration level, low in terms of cost and capable of improving the conduction and radiation performance of a testing circuit, and the circuit in the present application can also be used for other devices and can be used as a power adapter or a charger.

• 출원번호 : CN2024/109197
• 출원인 : CHANGZHOU SHENGDAN ELECTRICAL EQUIPMENT CO., LTD.
• 특허번호 :
• IPC : G01R-031/00(2006.01);G01R-031/40(2020.01);

The invention relates to a material comprising a transparent substrate coated with a functional coating that can act on solar radiation and/or infrared radiation. The invention also relates to glazings comprising said materials and to the use of said kind of materials for manufacturing thermal insulation and/or solar protection glazings. The invention is specifically concerned with developing a material comprising a functional coating which has two silver-based functional layers and has a selectivity close to that of functional coatings with three functional layers, while maintaining excellent color neutrality.

• 출원번호 : EP2024/071920
• 출원인 : SAINT-GOBAIN GLASS FRANCE
• 특허번호 :
• IPC : C03C-017/36(2006.01)