Novel compounds that are improved analogs and mimetics of DSHN and methods to treat or inhibit cancer using the compounds. The methods can require lower doses than for DSHN and the compounds can have a larger biological maximum than DSHN. Nuclear receptor NR0B2 is activated by the disclosed compounds to reduce immune-suppressive T, thereby attenuating tumor growth and metastasis. The therapy disclosed herein results in an inhibition of T expansion and an expansion of cytotoxic T cells. This therapy can significantly reduce tumor growth with lower doses compared to other available treatments.

• 출원번호 : US2024/024094
• 출원인 : THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS
• 특허번호 :
• IPC : C07D-209/60(2006.01);C07C-311/42(2006.01);

Asymmetric interferometry is used with various embodiments of Optical Photothermal Infrared (OPTIR) systems to suppress thin film interference effects. Systems and methods are described herein for operating a photothermal infrared microscope to accomplish these objectives. These can include illuminating a sample region with an infrared pump beam, splitting a probe beam into two paths (one towards the sample and the other towards a reference reflector), directing the probe beam towards the sample to create interfering radiation, collecting the interfering radiation as collected probe light, recombining the collected probe light with reflected probe radiation, dividing the recombined light between two detectors, and using signals from the detectors to generate a composite photothermal signal that suppresses the effects of thin film interference caused by the interfering radiation.

• 출원번호 : US2024/024138
• 출원인 : PHOTOTHERMAL SPECTROSCOPY CORP.
• 특허번호 :
• IPC : G01J-003/28(2006.01)

A method for reducing eyestrain relates to eye health and is applicable during the use of devices with screens. The claimed method is characterized in that during the viewing of information on a screen, the viewer's eyes are irradiated by sources of ultraviolet and infrared radiation. The source of ultraviolet radiation is a semiconductor source of radiation in a wavelength range of from 360 to 420 nm and with an irradiance of from 2 to 20% of the irradiance on the user's eyes from the screen. The source of infrared radiation in a wavelength range of from 720 to 1700 nm is an incandescent lamp or a semiconductor source of radiation with an irradiance of from 2 to 80% of the irradiance on the user's eyes from the screen. The invention reduces eyestrain and increases the perceived contrast and saturation of colours.

• 출원번호 : RU2024/050079
• 출원인 : VILISOV, Denis Victorovich
• 특허번호 :
• IPC : A61N-005/08(2006.01);A61F-009/00(2006.01);

The invention relates to a photonic device (1) comprising a photonic chip (PIC) comprising at least one waveguide (WG) arranged in the main plane (P) and at least one receiving zone (Z) arranged on a surface of the photonic chip (PIC), the waveguide (WG) and the receiving zone (Z) being optically coupled to each other in order to propagate internal light radiation formed of at least one mode. The photonic device also comprises a multi-plane conversion device (MPLC) assembled to the photonic chip (PIC) and comprising a first optical port (P1), optically associated with the receiving zone (Z) of the photonic chip (PIC), and a second optical port (P2) for receiving external radiation, the external light radiation being capable of propagating between the second optical port (P2) and the first optical port (P1) during a plurality of reflections and/or transmissions on microstructured zones of the multi-plane conversion device (MPLC).

• 출원번호 : EP2024/059729
• 출원인 : CAILABS
• 특허번호 :
• IPC : G02B-006/30(2006.01);G02B-006/42(2006.01);G02B-006/14(2006.01);

The invention relates to a method for determining state information with respect to a first sensor (1) for solar radiation, comprising the following steps: a) irradiating the first sensor (1) by means of a radiation source (3) which emits electromagnetic radiation (2), and capturing a first signal from the first sensor (1) during the irradiation, b) capturing an environmental signal generated by a second sensor (4) for solar radiation, wherein no or a negligible amount of electromagnetic radiation (2) from the radiation source (3) reaches the second sensor (4), c) determining a second signal from the first sensor (1), the second signal corresponding to an expected signal from the first sensor (1) without irradiation with the electromagnetic radiation from the radiation source, on the basis of the environmental signal from the second sensor (4), d) determining a differential signal by subtracting the second signal from the first sensor (1) from the first signal from the first sensor (1), e) evaluating the differential signal, wherein the state information with respect to the first sensor (1) is determined on the basis of the differential signal.

• 출원번호 : EP2024/059750
• 출원인 : DEUTSCHES ZENTRUM FÜR LUFT- UND RAUMFAHRT E.V.;
• 특허번호 :
• IPC : G01J-001/02(2006.01);G01N-021/94(2006.01);G01J-001/42(2006.01);

An optical fibre (10) comprising at least one first core (2) and at least one second core (12), wherein: the first core (2) comprises at least one active dopant (9); the first core (2) and the second core (12) are separated by a first cladding (3); the first cladding (3) has a first refractive index (5) which is less than a refractive index (4) of the first core (2) and less than a refractive index (14) of the second core (12); the optical fibre (10) being characterized in that: when the optical fibre (10) is configured in a straight line or with a uniform bend radius, first optical modes (101) having a first propagation constant β can propagate along the second core (12) but are isolated from the active dopant (9); and when the optical fibre (10) is subject to a perturbation (29), the first optical modes (101) can be coupled to second optical modes (102) having a second propagation constant β and which overlap the active dopant (9); thereby enabling control over at least one of a fractional inversion of the active dopant (9) along the optical fibre (10), an optical gain characteristic of the optical fibre (10), and a thermal load on the optical fibre (10), by propagating pump radiation along the second core (12) as the first optical modes (101), electively coupling the first optical modes (101) to the second optical modes (102) with one or more of the perturbations (29), and absorbing the pump radiation that has been electively coupled to the second optical modes (102) with the active dopant (9), which active dopant (9) is able to amplify by stimulated emission one or more signal modes (31) that are guided by the first core (2).

• 출원번호 : EP2024/059733
• 출원인 : TRUMPF LASER UK LIMITED
• 특허번호 :
• IPC : H01S-003/067(2006.01);H01S-003/094(2006.01);H01S-003/00(2006.01);H01S-003/04(2006.01);H01S-003/042(2006.01);H01S-003/0941(2006.01);H01S-003/16(2006.01);H01S-003/23(2006.01);

Systems and method for tissue treatment are provided. The systems include an electromagnetic radiation (EMR) source configured to generate a treatment EMR beam, a plurality of optical elements configured to shape and focus the treatment EMR beam to a focal point within a tissue, a window assembly located down-beam from the plurality of optical elements and configured to contact the tissue, and a controller configured to control the EMR source to generate the treatment EMR beam during a treatment procedure. The first axicon and the second axicon are configured to shape the treatment EMR beam such that the shaped EMR beam has a transverse asymmetric energy profile. The plurality of optical elements include a first axicon and a second axicon, and the window assembly is configured to transmit the treatment EMR beam.

• 출원번호 : US2024/023896
• 출원인 : AVAVA, INC.
• 특허번호 :
• IPC : A61B-018/20(2006.01);A61N-005/06(2006.01);

The present invention is provided with: a housing; an optical fiber that is connected to the housing and that causes heat radiation light from an object to enter the housing; a branch unit that is disposed in the housing and branches the heat radiation light into first light and second light; a first optical filter that is disposed in the housing and extracts a first component in a first wavelength range from the first light; a second optical filter that is disposed in the housing and extracts a second component in a second wavelength range from the second light; a first light detection unit that is disposed in the housing, detects the first component, and outputs a first signal corresponding to the light quantity of the detected first component; a second light detection unit that is installed in the housing, detects the second component, and outputs a second signal corresponding to the light quantity of the detected second component; and a calculation unit that calculates the temperature of the object on the basis of the ratio between the first signal output from the first light detection unit and the second signal output from the second light detection unit.

• 출원번호 : JP2024/014559
• 출원인 : HAMAMATSU PHOTONICS K.K.
• 특허번호 :
• IPC : G01J-005/60(2006.01);G01J-005/0802(2022.01);

A transmission line unit (2) of this multilayer substrate (101A) constitutes a strip line having an upper ground conductor (21), a lower ground conductor (22), and a signal line conductor (23). An antenna unit (1) has: a signal line conductor interlayer connection conductor (33) that electrically connects a radiation conductor (11) to the signal line conductor (23); and ground conductor interlayer connection conductors (31, 32) that electrically connect an upper surface annular ground conductor (12) to the lower ground conductor (22) and the upper ground conductor (21) of the transmission line unit (2). When viewed in the layering direction of a plurality of base materials, the entire surface of the radiation conductor (11) overlaps the lower ground conductor (22), and an end (21e) of the upper ground conductor (21) overlaps the signal line conductor (23) inside of an annular shape formed by the upper surface annular ground conductor (12) and is arranged at a position not overlapping the radiation conductor (11).

• 출원번호 : JP2024/014504
• 출원인 : MURATA MANUFACTURING CO., LTD.
• 특허번호 :
• IPC : H01Q-013/08(2006.01);H01Q-001/24(2006.01);H01Q-001/48(2006.01);H01Q-005/378(2015.01);H05K-001/02(2006.01);

A system and a method for determining a physiological parameter of a body comprising blood perfused tissue, the system comprising a first sensor configured to receive first radiation from the blood perfused tissue and, based on the received first radiation, provide first information relating to an amount of blood in the tissue, such as from an absorption of the first radiation in the tissue, a second sensor configured to receive second radiation from the blood perfused tissue and, based on the received second radiation, provide second information relating to a speed of blood in the tissue, such as from Doppler shift of the second radiation, a controller configured to determine the physiological parameter from the first information and the second information.

• 출원번호 : EP2024/059669
• 출원인 : SONION NEDERLAND B.V.
• 특허번호 :
• IPC : A61B-005/021(2006.01);A61B-005/024(2006.01);A61B-005/026(2006.01);A61B-005/00(2006.01);