The present invention provides agents and compositions for modulating expression (e.g., enhanced or reduced expression) of a hepatocyte nuclear factor 4 alpha (HNF4α) gene by targeting an HNF4α expression control region and methods of use thereof for treating an HNF4α associated disorder, e.g., cirrhosis.

• 출원번호 : 18637630
• 출원인 : Omega Therapeutics, Inc.
• 특허번호 :
• IPC : C12N-015/11(2006.01);C12N-009/22(2006.01);

A radiation device comprises: a housing comprising: a base portion; a head portion connected to the base portion; a radiation emission window in the head portion; a radiation source arranged in the region of the base portion in the interior of the housing for emitting electromagnetic radiation, the radiation source having an emission intensity maximum at a wavelength in the range from 350 to 600 nm; and a mirror arranged in the region of the head portion in the interior of the housing. A radiation path extends between the radiation source and the mirror. Electromagnetic radiation emitted by the radiation source arrives at the mirror via the radiation path. The electromagnetic radiation arriving at the mirror via the radiation path is reflected by the mirror, such that the reflected electromagnetic radiation exits the housing through the radiation emission window.

• 출원번호 : 18637795
• 출원인 : UTTERODT, Andreas
• 특허번호 :
• IPC : A61C-013/15(2006.01);A61K-006/884(2006.01);G02B-026/02(2006.01);G02B-026/08(2006.01);H05B-047/105(2006.01);

A measurement system for measuring at least one thermal magnitude at a point of a propulsion assembly of an aircraft. The measurement system is connected to a structure integral with the propulsion assembly and comprises at least one thermal sensor as well as at least one barrier transparent to infrared radiation in at least one zone of the barrier. The barrier at least partially delimits a cavity in which the thermal sensor is positioned. Also an aircraft propulsion system with at least one such measurement system.

• 출원번호 : 18637736
• 출원인 : FLEMIN, Christian
• 특허번호 :
• IPC : G01K-013/024(2006.01);F01D-017/08(2006.01);

An electromagnetic radiation sensor device (10) is described, comprising: a first photodiode (PD1) comprising a first semiconductor having a first forbidden band and having a first terminal (A1) connected to ground (GND) and a second terminal (C1); a second photodiode (PD2) comprising a second semiconductor having a second forbidden band and having a third terminal (A2) connected to a readout terminal (SNS) and a fourth terminal (C2) in direct contact with said second terminal (C1); a control device (CT) comprising: a control terminal (CTR) to receive a control voltage (VCTR ), a terminal connected to ground (GND) and a control terminal (D) connected to the second terminal (C1). In which the sensor device (10) such to assume the following operating conditions: a first condition in which the first photodiode (PD1) assumes a photovoltaic configuration to generate a first photo-current (Iph) and the second photodiode (PD2) is inhibited from generating a photo-current; a second condition in which the control device (CT) short-circuits the first photodiode (PD1) to ground and the second photodiode (PD2) assumes a photovoltaic configuration to generate a second photo-current (Iph) which is such that it reaches the readout terminal (SNS).

• 출원번호 : IB2024/053753
• 출원인 : EYE4NIR S.R.L.
• 특허번호 :
• IPC : H01L-031/101(2006.01);H01L-031/0216(2014.01);H01L-031/103(2006.01);H01L-031/105(2006.01);H01L-027/144(2006.01);

하나 이상의 산 스핑고미엘리나제의 기능성 억제제(FIASMA)를 사용하여 방사선 피부염, 방사선 직장병증(radiation proctopathy) 또는 구강 점막염을 포함하는 피부 방사선 손상(CRI)을 치료하기 위한 조성물 및 방법.

• 출원번호 : 10-2024-7012575
• 출원인 : 라이테라 쎄라퓨틱스 아이엔씨.
• 특허번호 :
• IPC : A61K-031/135;A61K-031/137;A61K-009/00;A61K-009/06;A61K-009/20;A61P-017/16;

Described herein arc RF systems and techniques for detecting the presence of and/or characterizing RF signals among RF radiation received by the system. In some embodiments, RF signal characterization may be achieved with high accuracy and low sensitivity while using low cost, scalable electronics that are versatile for deployment in a variety of environments, whether centralized, distributed, and/or vehicle-based. In some embodiments, underlying such systems and techniques are trained models that may be executed by a processor and configured to detect the presence of and/or characterize received RF signals. In some embodiments, received RF signals may be encoded into compact data structure representations that may be transmitted over low bandwidth links and/or processed using fewer computing resources than processing the underlying RF radiation data itself, facilitating deployment of distributed RF sensing systems.

• 출원번호 : US2024/024828
• 출원인 : DISTRIBUTED SPECTRUM INC.
• 특허번호 :
• IPC : H04B-001/00(2006.01);H04W-024/00(2009.01);G06F-018/214(2023.01);H04B-017/30(2015.01);G06N-020/00(2019.01);G06N-003/02(2006.01);G01R-029/08(2006.01);

The invention consists in combining a source of ultraviolet radiation with an electric field source in the form of a part made of an electret or a capacitor plate with a small surface area. Under the effect of the electric field, bacteria and viruses in the air will be attracted by electrostatic induction to the electric field source, which is arranged in the vicinity of the source of ultraviolet radiation, where the flux density of the energy emitted will be greater than in other regions of the irradiated space. Thus, less energy will be required to destroy the same number of bacteria and viruses by comparison with the prior art, where bacteria and viruses are evenly spread throughout the entire volume of irradiated air. An optical focusing system may be included to increase the flux density of the ultraviolet radiation in the vicinity of the electric field source.

• 출원번호 : RU2024/000134
• 출원인 : SAMOSVAT, Anton Sergeevich
• 특허번호 :
• IPC : A61L-009/20(2006.01);A41D-013/11(2006.01);H01G-007/02(2006.01);

The invention relates to a container (13) for receiving pipette tips (15) and/or fluids for use in a laboratory with a base (21) and at least one side wall (23). The base (21) or at least one of the side walls (23) has a marking (27) which is applied to the outer surface of the base (21) or the side wall (23). The marking (27) determines the type of container (13) and its capacity for fluids and/or the type of pipette tips arranged therein. The marker (27) comprises a material which causes a shift in the wavelength between the electromagnetic radiation absorbed and emitted by the marking.

• 출원번호 : CH2024/050020
• 출원인 : INTEGRA BIOSCIENCES AG
• 특허번호 :
• IPC : B01L-003/00(2006.01);G01N-035/00(2006.01);B01L-009/00(2006.01);

Provided are: a radiation-sensitive composition which is capable of exhibiting sufficient levels of sensitivity, LWR performance, CDU performance and MEEF performance during formation of a resist pattern, and has satisfactory storage stability; a pattern formation method; and an onium salt compound.　The radiation-sensitive composition comprises: an onium salt compound represented by formula (1); a polymer containing a structural unit having an acid-dissociable group; and a solvent.　(In formula (1), A represents a monovalent organic group having 1 to 40 carbon atoms. R and R each independently represent a hydrogen atom, a cyano group, a nitro group, a hydroxy group, an alkoxy group, an alkylthio group, an amino group, a mercapto group, a monovalent hydrocarbon group having 1 to 20 carbon atoms, or a monovalent hydrocarbon group having 1 to 20 carbon atoms and substituted by at least one of a cyano group, a nitro group, a hydroxy group, an alkoxy group, an alkylthio group, an amino group, a mercapto group, a chlorine atom, a bromine atom and an iodine atom. When a plurality of R's and a plurality of R's are present, the plurality of R's and the plurality of R's are respectively identical or different from each other. At least one of R and R is a cyano group or a nitro group. m represents an integer of 1 to 8. L represents -COO-, -OCO-, -CO- or -OCOO-, and represents an A-side bonding hand. However, when m is 1, L is -COO-, -CO- or -OCOO-. Z represents a monovalent radiation-sensitive onium cation.)

• 출원번호 : JP2024/015136
• 출원인 : JSR CORPORATION
• 특허번호 :
• IPC : G03F-007/004(2006.01);G03F-007/20(2006.01);G03F-007/038(2006.01);G03F-007/039(2006.01);

Methods and systems are provided for calibrating a single photon emission computed tomography (SPECT) imaging system. In one example, a collimated line source (331) for calibrating a SPECT imaging system (100) comprises a radioactive material aligned along a central axis (348) of the collimated line source (331) and a plurality of collimator plates (335) arranged perpendicularly around the central axis (348), the collimator plates including a material with an atomic number and a density to substantially absorb photons striking the collimator plates (335). The collimator plates (335) may absorb photons emitted by the radioactive material in non-perpendicular directions, which are not used for calibrating the SPECT imaging system (100), thereby reducing an amount of radiation released in an environment of the SPECT imaging system (100) during calibration. Due to the reduced amount of radiation to which people in the environment are exposed, short time increments between patient examinations may be advantageously used to collect calibration data, reducing an overall amount of time used for calibration.

• 출원번호 : 24170391.7
• 출원인 : GE Precision Healthcare LLC
• 특허번호 :
• IPC : G01T-001/164(2006.01);A61B-006/03(2006.01);