Abstract Introduction & Objectives : Heat shock protein 90 (HSP90) participates in stabilizing and activating client proteins involved in malignant transformation. This study aims to determine whether there are different values for the expression of HSP90 in Conjunctival Intraepithelial Neoplasia (CIN) and Conjunctival Squamous Cell Carcinoma (CSCC). Methods : A total of 24 OSSN samples, including 15 cases of CIN and 9 cases of CSCC were evaluated. The immunohistochemical expression of HSP90 was assessed using a scoring system based on the percentage of positive staining of nuclear and cytoplasmic cells, then the intensity of staining was evaluated using the German Immunoreactive Score. Results : In the study, the average cytoplasmic Immunoreactive Score in CIN was 9.87 and CSCC was 16.89 with a significant result (p=0.007), while the average nuclear Immunoreactive Score in CIN was 11.30 and CSCC was 14.50 with insignificant results (p=0.274). The results of the correlation test showed that the cytoplasmic expression groups with low categories were all in CIN as much as 6 (100%) so they had a ratio of 6:0. and the high category of HSP90 cytoplasmic expression group was only found in CSCC as many as 2 (100%) samples with a ratio of 0:2. The results of the correlation test using the Pearson test obtained a significant correlation value (p=0.006) with a moderate correlation strength (r=0.545). Conclusion : There are differences in the expression of cytoplasmic and nuclear HSP90 but only the cytoplasmic expression of HSP90 is significantly associated with CIN and CSCC.

• Book : 49(S2)
• Pub. Date : 2024
• Page :
• Keyword :

Background: Lots of religious beliefs and doctrines among clergy in Christianity, Islam and traditional worshippers have determined the outcome of pregnancy and health of pregnant mothers in developing countries making them occasionally go through unnecessary risks of childbirth and postpartum conditions. Hence, a study to assess the influence of belief of religious leaders on the acceptance of Caesarean Section as a choice of child delivery is paramount. Methods: A cross-sectional study was conducted in April, 2023 among religious leaders and a total of 422 of them were selected randomly and interviewed using a structured interviewer-administered questionnaire. Results: About 164(38.9%) were below 40 years, 272(64.5%) were males, 150(35.5%) were females; majority 273(64.7%) practice Christianity, 138(32.7%) practice Islam; 354(83.9%) belong to the Yoruba ethnic group; more than half of the respondents 293(69.4%) were married; 314(74.4%) had a nuclear family structure; majority 302(71.6%) had tertiary education; 186(44.1%) were employed, 168(39.8%) were self-employed. 372(88.2%) believed that Caesarean sections a method of child delivery; less than half 144(34.1%) believed that Caesarean section is only used for emergency; 151(35.8%) believed that Complications of caesarean section are more than normal vaginal delivery; 198(46.9%) believed that Caesarean section is an easy way of delivery; 82(19.4%) believed that Caesarean section benefits only the mother; 80(19.0%) believed that Caesarean section affects the bonding between mother and child; amongst others. Conclusion: The study reveals that religious leaders in Ogbomoso will require more scientific information about caesarean section, and a significant proportion of them hold misconceptions about the procedure. Nevertheless, the majority of the religious leaders in the study were willing to accept caesarean section as a mode of delivery. Given their role in influencing their members' health-seeking behaviour, religious leaders could play a significant role in improving maternal and child health outcomes in the community by promoting accurate information about caesarean section and encouraging its acceptance.

• Book : 7(02)
• Pub. Date : 2024
• Page : pp.49-59
• Keyword :

AbstractJurassic sedimentary sequences suitable for nuclear waste storage in northern Germany consist of organic-lean claystone and were uplifted to < 100 m depth in the Hils Syncline area (southern Lower Saxony Basin). This Hils Syncline, showcasing a northwestward increase in thermal maturity, facilitates the study of shale petrophysical properties influenced by burial history. This study introduces a 3D-thermally calibrated numerical model of the Hils Syncline area to analyze its geodynamic evolution and maturity variations. It provides new vitrinite reflectance and sonic velocity data for modeling calibration and erosion estimation. The Hils Syncline area has undergone continuous subsidence, interrupted by a Cretaceous uplift documented by an erosional unconformity. During the latest Early Cretaceous, Jurassic rocks underwent maximum burial reaching up to several thousand meters depth and temperatures up to 160 °C in the northwest. The Late Cretaceous inversion caused stronger erosion towards the northwest removing up to 3300 m of sediment compared to about 1300 m in the south, according to vitrinite reflectance-based estimations. Numerical modeling results along the study area indicate decreasing porosity and permeability northwestward with increasing thermal maturity. Porosity and vertical permeability decreased to 5–14% and 2.8 × 10–23 to 1.5 × 10–19 m2 [1 mD = 10−15 m2], respectively, while vertical thermal conductivity increased to 1.30–2.12 (W/m/K). These trends of porosity/permeability and thermal conductivity with burial align with sonic velocity and published experimental porosity data, except for the thermally most mature region (Haddessen). This anomaly is tentatively attributed here to localized overpressure generation in the Posidonia Shale during maximum burial, affecting both the underlying Pliensbachian and overlying Doggerian units. Graphical abstract 3D numerical model of the Hils Syncline and surrounding area revealing that a northwestward increase in maximum burial resulted in higher temperatures and varying maturity levels. While most locations align well with calibration data (i.e. measured vitrinite reflectance and porosity), discrepancies arise in the Haddessen/Bensen area. The mismatch between porosity, vitrinite reflectance, and sonic velocity response indicates local overpressure in the northernmost region mainly during the Cretaceous. It was likely caused by gas generation in the Posidonia Shale affecting nearby Lower and Middle Jurassic units.

• Book : ()
• Pub. Date : 2024
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AbstractBackgroundMolecular ageing clocks estimate an individual’s biological age. Our aim was to compare multiple machine learning algorithms for developing ageing clocks from nuclear magnetic resonance (NMR) spectroscopy metabolomics data. To validate how well each ageing clock predicted age-related morbidity and lifespan, we assessed their associations with multiple health indicators (e.g., telomere length and frailty) and all-cause mortality.MethodsThe UK Biobank is a multicentre observational health study of middle-aged and older adults. The Nightingale Health platform was used to quantify 168 circulating plasma metabolites at the baseline assessment from 2006 to 2010. We trained and internally validated 17 machine learning algorithms including regularised regression, kernel-based methods and ensembles. Metabolomic age (MileAge) delta was defined as the difference between predicted and chronological age.ResultsThe sample included 101,359 participants (mean age = 56.53 years, SD = 8.10). Most metabolite levels varied by chronological age. The nested cross-validation mean absolute error (MAE) ranged from 5.31 to 6.36 years. 31.76% of participants had an age-bias adjusted MileAge more than one standard deviation (3.75 years) above or below the mean. A Cubist rule-based regression model overall performed best at predicting health outcomes. The all-cause mortality hazard ratio (HR) comparing individuals with a MileAge delta more than one standard deviation above and below the mean was HR = 1.52 (95% CI 1.41-1.64,p< 0.001) over a median follow-up of 13.87 years. Individuals with an older MileAge were frailer, had shorter telomeres, were more likely to have a chronic illness and rated their health worse.ConclusionsMetabolomic ageing clocks derived from multiple machine learning algorithms were robustly associated with health indicators and mortality. Our metabolomic ageing clock (MileAge) derived from a Cubist rule-based regression model can be incorporated in research, and may find applications in health assessments, risk stratification and proactive health tracking.

• Book : ()
• Pub. Date : 2024
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Aim of the Study: Study of the production of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF-α) in patients with Chronic Epstein-Barr Viral Infection (CEBI). Material and Methods: 90 patients with CVEBI were examined. The group consisted of 66 women and 24 men. The average age of the patients was 38.37 ± 1.15 years. The duration of the course of CVEBI from the appearance of the patient’s first complaints to diagnosis was 3.73 ± 0.22 years. The amount of EBV DNA in saliva samples (PCR method) and the level of production of the cytokine TNF-α ware examined in patients. Results: The copy number of EBV DNA in saliva samples from patients was 135898.61±23196.21 cop/ml. The level of induced TNF-α in the general group was 3288.73±260.88. All patients were divided into three groups: group 1 (n = 49) - the level of induced TNF-α was reduced - 1624.69±105.53 (pg/ ml) (95% CI: 1412.52; 1836.86) ; Group 2 (n =30) - the level of induced TNF-α is normal - 3819.19 ±427.00 (pg/ml) (95% CI: 3045.27; 4701.81); Group 3 (n =11) the level of induced TNF-α is high – 7203.00 ± 627.50 (pg/ml) (95% CI: 6135.37 - 8609.87). Patients did not differ in age, disease duration, or number of EBV DNA copies in saliva samples. The linear and exponential regression method was used to show the effect of disease duration on the level of TNF-α production in the general group of patients (R2 =0.386 F=55.925 p=0.0001 β=0.621 and R2 =0.735 F=246.808 p=0.0001 β=0.857, respectively). TNF-α influences the development of headaches in patients (Pearson correlation R = 0.223 p = 0.040) and the severity of postnasal drip (r = -0.231 p = 0.033 τ = - 0.171 p = 0.039). Conclusion: The study showed that the duration of the disease affects the level of production of induced TNF-α. TNF-α levels contribute to the development of headaches and postnasal drip in patients in the general group.

• Book : ()
• Pub. Date : 2024
• Page : pp.1-10
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Symmetrical solid oxide cells (SSOCs) are very useful for energy generation and conversion. To fabricate the electrode of SSOC, it is very time‐consuming to use the conventional approach. In this work, we design and develop a novel method, extreme heat treatment (EHT), to rapidly fabricate electrodes for SSOC. We show that by using the EHT method, the electrode can be fabricated in seconds (the fastest method to date), benefiting from enhanced reaction kinetics. The EHT‐fabricated electrode presents a porous structure and good adhesion with the electrolyte. In contrast, tens of hours are needed to prepare the electrode by the conventional approach, and the prepared electrode exhibits a dense structure with a larger particle size due to the lengthy treatment. The EHT‐fabricated electrode shows desirable electrochemical performance. Moreover, we show that the electrocatalytic activity of the perovskite electrode can be tuned by the vigorous approach of fast exsolution, deriving from the increased active sites for enhancing the electrochemical reactions. At 900 °C, a promising peak power density of 966 mW cm−2 is reached. Our work exploits a new territory to fabricate and develop advanced electrodes for SSOCs in a rapid and high‐throughput manner.

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• Pub. Date : 2024
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The incidence of cutaneous metastasis in head and neck cancers is less than 1%. Carcinoma of the oral cavity is one of the most common cancers of the head neck region with frequent metastasis to internal organs, especially the lungs, liver, and bone.We present a case of Carcinoma of floor of mouth with cutaneous metastasis.A 55 year old lady presented to our department with complaints of non-healing ulcer in the oral cavity and ulcerated nodules over neck and chest. On examination, mouth opening tongue mobility was restricted with grade 2 trismus. An ulcer in left gb sulcus, bilateral lymphadenopathy and multiple ulcerated skin nodules on neck and chest wall were noted. CECT Face and Neck showed heterogenously ehancing mass at the floor of mouth involving left buccal mucosa and erosion of mandible, lymph node mets and skin nodules. ECOGPS was 1.She was treated with palliative systemic chemotherapy and thereafter Palliative radiation. Now she is having stable disease and is on metronomic chemotherapy with regular follow up.Our case has highlighted that cutaneous metastasis can be seen in the cancers of floor of mouth. Palliative chemotherapy and radiotherapy can significantly increase Progression free survival and hence the Quality of life of patients with such presentation.

• Book : 9(4)
• Pub. Date : 2024
• Page : pp.147-149
• Keyword :

The multifaceted health benefits of curcumin (Curcuma longa), attributed to its antioxidant, antitumor, and anti-inflammatory activities, have drawn significant scientific attention. Curcumin shows promise as a potential modulator of macrophage polarization, offering a natural strategy for managing inflammation and promoting tissue repair. However, a limiting factor for this beneficial molecule is its limited bioavailability due to its low solubility in water. This study aimed to quantify the effect of curcumin gold nanoparticle (CurAuNP)-mediated ultrasound irradiation on THP-1-derived macrophages as potential therapeutic targets. The photoreduction method was applied to synthesize the gold nanoparticles with curcumin as a ligand (CurAu). The effect of adding polyethylene glycol in the synthesis process was studied (CurAuPEG). CurAuNP characterization included UV/Vis, Zeta potential, transmission electron microscopy, and FTIR. The amount of singlet oxygen released by curcumin and CurAuNPs was quantified by observing 1.3-diphenylisobenzofuran quenching upon ultrasound irradiation (1 MHz and 1 W/cm2). The results indicated that ultrasound therapy for 4 min with CurAuNPs significantly enhanced singlet oxygen generation and reduced macrophage viability compared to curcumin alone. The increased sonoluminescence and curcumin delivery facilitated by CurAuNPs led to greater curcumin activation. Consequently, CurAuNPs could offer promising therapeutic options for modulating macrophage polarization in pro-inflammatory and anti-inflammatory stages.

• Book : 4(1)
• Pub. Date : 2024
• Page : pp.70-85
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Currently, there is an active growth in the use of unmanned systems in various spheres of activity. The qualitative fulfillment by unmanned systems of their target tasks depends on the efficiency of information exchange channels for their control, which consists of several criteria, which makes the problem of its evaluation a multi-criteria one. This article presents the corresponding evaluation methodology, which is based on the use of the probability of achieving a set of functioning goals as a generalized efficiency indicator. To determine the probability, the widely used Rosenblatt-Parzen nuclear estimation method is used. The main stages of the methodology are described and recommendations for its use in the framework of ensuring qualitative fulfillment by unmanned systems of their target tasks are offered.

• Book : 10(1)
• Pub. Date : 2024
• Page : pp.18-25
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This study presents a solar energy roadmap aimed at attracting investors to capitalize on the abundant solar resources in Zakho, Iraq, for clean energy technology. The objective is to mitigate global warming effects caused by fossil fuel combustion and promote sustainable technological development. To end this, the study employs RETScreen Expert software to validate the techno-economic and environmental viability of a grid-connected solar photovoltaic system utilizing climatic data from the Astronaut Office Information System (NASA) Database. Additionally, the Photovoltaic Geographical Information System (PVGIS) modeling method determines optimal angles for installing residential rooftop Photovoltaic (PV) systems across selected locations. Results indicate that all selected locations are suitable for solar photovoltaic projects, with Rezgari identified as the optimal district due to its highest annual solar radiation of 1863.117 kWh/m2 and the highest annual electricity production at 7905.38 kWh. The capacity factor (CF) values fall within the range of 17.395-17.574%. The study reveals an annual greenhouse gas (GHG) emissions reduction ranging from 6.9876 to 7.1123 (tCO2) across four districts. Considering the financial and environmental indicators, Rooftop Photovoltaic Systems emerge as a sustainable and efficient solution to enhance the environment and prove economically viable in Zakho City.

• Book : ()
• Pub. Date : 2024
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