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2025
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2025
AbstractWe document results of a set of laboratory experiments aimed at exploring impacts of injection rate and bacterial density on biomineralization across water‐saturated porous media. The study relies on a Low‐Field Nuclear Magnetic Resonance technology and the ensuing transverse spin‐spin relaxation time distributions. The latter is documented to provide a robust quantification of temporal histories of pore size distributions during biomineralization. As such, our work explores and quantifies pore‐size dependent biomineralization across the three‐dimensional pore space. The study also provides a quantitative analysis of alterations in porosity and permeability induced by biomineralization, together with a quantification of (time‐averaged) rates of pore volume change. A plugging ratio efficiency index is introduced to quantify the strength of pore‐size‐related biomineralization. Our results reveal that biomineralization induces significant alterations in the pore size distribution within a porous medium, these changes being modulated by bacterial density and injection rate. We find that CaCO3 mainly precipitates in macropores, consistent with the presence of favorable local hydrodynamic conditions and large surface areas therein. Precipitated CaCO3 volume is found to increase with bacterial density. High bacterial densities amplify rate of pore volume change within macropores and adequate plugging ratio of biomineralization and contribute to a significant permeability reduction. Otherwise, a diminished strength of biomineralization in mesopores and micropores is documented for the highest injection rates considered.- Book : 61(1)
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2025
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2025
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2025
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2025
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2025
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2025
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2025
Background: Coronavirus disease 2019 (COVID-19) was identified in China in late December 2019 and led to a pandemic that resulted in millions of confirmed cases and deaths. The causative agent, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), uses distinct receptors and co-receptors to enter host cells. Vimentin has emerged as a potential co-receptor for SARS-CoV-2 due to the high level of vimentin expression in testis tissue.
Objective: The present study investigated the link between vimentin expression level and SARS-CoV-2-induced orchitis.
Materials and Methods: In this case-control study, testis autopsy samples were collected immediately after the death of both COVID-19 cases and a control group that included individuals who died due to accidental causes. Gene expression and immunohistochemical assays were conducted to evaluate the level of vimentin expression, cell proliferation, and leukocyte infiltration.
Results: A significant expression of vimentin and infiltration of immune cells (CD68+, CD38+, and CD138+) in the testicular tissue of COVID-19 cases, along with extensive immunoglobulin G precipitation and reduced inhibin expression (p = 0.001) were observed. Additionally, gene expression analysis revealed increased expression of vimentin and decreased expression of the proliferation markers Ki67 and proliferating cell nuclear antigen, suggesting that SARS-CoV-2 may disrupt spermatogenesis through immune responses and the arrest of cell proliferation.
Conclusion: There may be a strong link between vimentin expression and COVID-19-induced orchitis. Further studies are needed to confirm these findings. Considering some limitations, vimentin can be used as a biomarker option for testicular damage following COVID-19-induced orchitis.- Book : 22(11)
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2025
In this study, a nanocomposite based on copper oxide–zinc oxide nanoparticles and Gum Arabic (GA@CuO–ZnO nanocomposite) was successfully synthesized using green method for increasing antimicrobial and anticancer activities.- Book : 15(1)
- Pub. Date : 2025
- Page : pp.513-523
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