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Introduction/Objective. Isocitrate dehydrogenase mutations play a
significant role in gliomagenesis. Specific microRNAs such as miR-10b/21 act
as oncogenic microRNAs, while miR-34a acts as tumor suppressors in
glioblastoma. Our study aimed to investigate the mutation status of IDH
correlate with microRNAs-10b/21/34a expression levels in patients with
glioblastoma. Methods. The study included 43 patients diagnosed with
glioblastoma. We examined microRNA-10b, microRNA-21 and microRNA-34a
expression levels in peripheral blood mononuclear cells after surgery and
prior to concurrent radiotherapy with temozolomide, at the 15th and 30th
fractions of radiotherapy with temozolomide. The data on IDH1 mutation
status were gathered from medical history and histopathology. Results. Two
groups were created to assess the association of microRNAs-10b/21/34a
expression levels: glio-blastoma IDH1-wild type and glioblastoma
IDH1-mutant + Not Other Specified (NOS). The median microRNA-10b
expression level before the initiation of concurrent radiotherapy with
temozolomide was 130.44 (52.20 - 622.53) in the IDH1-wildtype glioblastoma
group and 94.61 (2.13 - 816.89) in the IDH1-mutant + glioblastoma NOS group.
The median microRNA-21 expression level was 57.16 (2.68 - 278.98) in the
IDH1-wildtype glioblastoma group and 69.74 (4.60 - 825.43) in the
IDH1-mutant + glioblastoma NOS group. The median microRNA-34a expression
level was 13.52 (3.16 - 105.20) in the IDH1-wildtype glioblastoma group and
10.11 (1.00 - 210.55) in the IDH1-mutant + glioblastoma NOS group. The
results showed no statistically significant difference in the expression
levels of miR-10b/21/34a between the two groups (p > 0.05). Conclusion. Our
results suggest that the IDH1 mutation status may not be a critical factor
for altered expression of microRNAs-10b/21/34a in glioblastoma patients.- Book : (00)
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