The quest for alternatives to traditional cold chain preservation and heat-based shelf-life extension has become increasingly important in recent years. As a result, investigation into the effects of ultraviolet (UV) radiation on the physicochemical properties of various substances, including milk, has gained significant attention. UV-C light, in particular, is recognized for its effectiveness in inactivating a wide range of bacteria and spores in aqueous solutions. This work aims to design a continuous annular UV reactor for milk treatment to examine the impacts on milk’s microbial and physicochemical characteristics and compare these outcomes to those achieved through conventional pasteurization methods. For the same, a 11 W conventional UV-C lamp (254 nm) and an in house designed 17.5 W far UV-C (222 nm) lamp have been used. The key parameters, such as pH, conductivity, temperature, fat/solid not fat, and microbial load, are assessed. The UV dosage supplied to milk samples is determined using actinometry and measured to be 6.16 J/ml. The methylene blue reduction test of milk increases up to more than 5 h, with just four passes through the UV reactor. Approximately 5 log reductions in the Salmonella typhimurium and Staphylococcus aureus have been achieved in just three passes (residence time 24.3 s) of whole milk. The results obtained are compared to those obtained using the pasteurization technique. We found that the proposed UV reactor has an identical performance in inactivating the micro-organisms compared to pasteurization without altering the physico-chemical properties. This suggests the possibility of utilizing UV sources to improve milk’s safety, quality, and shelf life. This study expands the scope of applications for UV-C irradiation as a feasible non-thermal method in the dairy industry.

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AbstractOne hypothesized mechanism that triggers deep‐focus earthquakes in oceanic subducting slabs below ∼300 km depth is transformational faulting due to the olivine‐to‐spinel phase transition. This study uses finite element modeling to investigate phase transformation‐induced stress redistribution and material weakening in olivine. A thermodynamically consistent constitutive model is developed to capture the evolution of phase transformation in olivine under different pressure and temperature conditions. The overall numerical model enables considering multiscale material features, including the polycrystalline structure, mesoscale heterogeneity, and various phases or variants of phases at the microscopic level, and accounts for viscoplastic behaviors with thermo‐mechanical coupling effects. The model is validated with several benchmarks, including a phase diagram of phase transformation from olivine to spinel. The validated model is used to study the interactive behaviors between defects (heterogeneity) and phase transformation. The simulation results reveal that spinel formation under pressure initiates near inclusions and along the grain boundaries, consistent with experimental observations. At lower temperatures, the transformation leads to the formation of thin conjugate bands of spinel diagonal to the compression loading direction. Local stress analysis along these bands also suggests the initiation of faulting. In contrast, the numerical results at higher transformation rates show that significant spinel formation occurs over a larger area at elevated temperatures, leading to ductile behavior, which agrees with experimental findings. Numerical simulation of multiple inclusions under confined pressure also shows the formation of a network of spinel bands resembling phase‐transformation patterns observed in the laboratory experiments. Additionally, stress softening patterns due to phase transformation are similar to experimental observations.

• Book : 130(2)
• Pub. Date : 2025
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Abstract Purpose To investigate the presence of tubulation in the outer nuclear layer of patients with Bietti crystalline dystrophy (BCD) using optical coherence tomography (OCT) and evaluate its relationship with visual field, visual field progression, and retinal volume. Methods This retrospective cross-sectional study included 37 patients diagnosed with BCD who underwent spectral-domain OCT examination. OCT examinations and Humphrey visual field tests (10–2 program) were conducted. We performed correlation analyses to assess the correlation of the number of tubulations with the visual field parameters and retinal volume. We also compared the number and prevalence of tubulations in groups based on median values of the parameters. The primary outcome measure was the number and prevalence of tubulations. Results The average age of the participants was 58.7 ± 9.6 years. The mean deviation (MD) value was −25.0 ± 9.0 decibels (dB). The MD slope value during an average follow-up period of 5.9 ± 3.8 years was −0.91 ± 1.02 dB/year. The number of tubulations tended to increase as the MD values worsened (P = 0.055, r = −0.33). Moreover, the number (P = 0.48) and prevalence (P = 0.42) of tubulations tended to be higher in the group with lower MD values. The number of tubulations decreased with worsening logarithmic minimum angle of resolution (logMAR) (P = 0.68, r = −0.07). The prevalence of tubulations was higher in the group with poorer logMAR (P = 0.068). We observed no significant correlations between the number of tubulations and the retinal outer, inner, or center volume (P = 0.46, r = −0.13; P = 0.76, r = 0.05; P = 0.47, r = 0.12, respectively). However, the prevalence of tubulations in the group with smaller retinal center volume was lower (P = 0.054). Conclusion The number of tubulations correlated with the severity of visual field loss in patients with BCD; however, it did not correlate with visual field progression or retinal volume measurements. Further studies are needed to understand the development of tubulations and their implications for retinal atrophy in BCD.

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Purpose: Peptide Receptor Radionuclide Therapy (PRRT) with 177Lu-DOTATATE (177 Lu DOTA-TATE therapy is a form of PRRT which targets Somatostatin Receptors (SSR). It is a form of targeted drug delivery, which is applicable to treat neuroendocrine tumors. PRRT applications are continuously expanding in most departments of nuclear medicine in Iran, but the best of all, no one has studied the mean doses of organs of the patients. This research aims to specify the absorbed dose to patients for the treatment of neuroendocrine tumors using imaging with 177Lu-[DOTA0-Tyr3] octerotate. Materials and Methods: Whole body planar scintigraphy images were collected for 10 patients, which are used as the basis for the personalized patient dosimetry calculations. The patients had a mean age of 53.5 ± 12 years (ranging from 36 to 70 years) and imaging data were collected at roughly 0 to 2 hours, 4 to 6 hours, 18 to 24 hours, and 36 to 48 hours after the injection of 6401± 628.4 MBq (range of 5500 MBq-7400 MBq) of 177Lu-[DOTA0-Tyr3] octerotate. Models of time-activity were established for different organs. Finally, using absorbed dose formulation and IDIAC-Dosage software, the mean absorbed dose in the organs was determined. Results: Mean calculated dose in the kidney and liver were obtained as 0.30-0.82 mGy/ MBq, and 1.05-2.11 mGy/MBq, respectively. Conclusion: Based on the results, PRRT therapy is a safe method for the treatment of castration-resistant neuroendocrine cancer patients in terms of patient dose. Large inter-individual differences in organ dose were discovered, highlighting the importance of patient-specific dosimetry and treatment planning in the treatment with 177Lu-DOTATATE.

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