• Book : 521(p1)
• Pub. Date : 2025
• Page : pp.113566
• Keyword :

• Book : 51()
• Pub. Date : 2025
• Page : pp.102161
• Keyword :

• Book : 1010()
• Pub. Date : 2025
• Page : pp.116754
• Keyword :

ABSTRACT

This study aimed to explore the effect of toll‐like receptor 4 (TLR4)/nuclear factor‐kappa B (NF‐κB)/NOD‐like receptor thermal protein domain‐associated protein 3 (NLRP3) signalling on Henoch-Schonlein purpura nephritis (HSPN). We established a HSPN rat model in a high‐altitude hypoxic (HH) environment. Renal tissue lesions were observed by haematoxylin and Eosin (H&E) staining and terminal deoxynucleotidyl transferase‐mediated dUTP nick end labelling (TUNEL), CD20‐postive B cells and CD68‐postive macrophage cells were detected by immunohistochemistry, T‐cell activation was detected by flow cytometry and toll‐like receptor 4 (TLR4)/nuclear factor‐kappa B (NF‐κB)/NOD‐like receptor thermal protein domain associated protein 3 (NLRP3) signalling was detected by western blot. TAK‐242 inhibited the expression of TLR4/NF‐κB/NLRP3 signalling related‐proteins, decreased the levels of 24 h urinary protein, serum creatinine, circular immune complex (CIC) and kidney immunoglobulin A (IgA), and improved renal histopathological damage in HH‐HSPN rats. Furthermore, TAK‐242 attenuated the infiltration of CD20 and CD68 into the kidney and increased the percentage of CD3+, CD4+ and CD4+/CD8+ cells in the blood of HH‐HSPN rats. The study revealed that suppressing TLR4/NF‐κB/NLRP3 signalling improved renal function and histopathological damage, and this improvement was related to inhibiting the inflammatory response and enhancing immune competence.

• Book : 52(1)
• Pub. Date : 2025
• Page : pp.e70008
• Keyword :

• Book : 1054()
• Pub. Date : 2025
• Page : pp.122983
• Keyword :

Abstract

Background

Adult survivors of unilateral, nonmetastatic, non‐syndromic Wilms tumor (WT) treated with whole abdomen radiation therapy (WART) are at risk for impaired kidney function. The impact of bias and accuracy on estimated glomerular filtration rate (eGFR) among adult survivors of WT has not been well documented.

Procedure

We clinically evaluated male and female WT survivors with creatinine and cystatin C, calculated eGFR using the Chronic Kidney Disease-Epidemiology equations with and without cystatin C, and measured ^99mTc diethylenetriamine pentaacetic acid (DTPA) plasma clearance. WT survivors treated with unilateral nephrectomy (UN), non‐nephrotoxic chemotherapy (NNC) and WART or treated with UN, no radiation therapy, and NNC were enrolled. Correlations between ^99mTc DTPA clearance and eGFR were calculated. Bias and the percentage of eGFR calculations that differed from the ^99mTc DTPA clearance by 10% or less (P10) or 30% or less (P30) (accuracy) were calculated.

Results

Among female WT survivors, none of the eGFR calculations was statistically significantly correlated with ^99mTc DTPA clearance. Among both unirradiated and WART‐treated male WT survivors, ^99mTc DTPA clearance correlated well with eGFR calculations that included creatinine. eGFR calculations that included creatinine were positively biased among female participants compared to ^99mTc DTPA clearance, and no P30 was greater than 90% among either irradiated males or females.

Conclusions

Among female survivors of unilateral, nonmetastatic, non‐syndromic WT who have undergone UN, eGFR is poorly correlated with, is positively biased, and lacks sufficient accuracy, compared to ^99mTc DTPA clearance.

• Book : 72(1)
• Pub. Date : 2025
• Page : pp.e31409
• Keyword :

Abstract

Sulfonamide derivatives as semiconductor materials for organic optoelectronic devices, including photovoltaic (PV), have received considerable interest. In the present work, the synthesis of novel pyrogallol-sulfonamide derivatives based on a molecular hybridization approach yielded N-((4-((2,3,4-trihydroxyphenyl)diazenyl)phenyl)sulfonyl)acetamide (N-DPSA). The techniques of spectroscopy, Fourier transform infrared spectroscopy (FTIR), nuclear magnetic resonance (¹H NMR), and mass spectrum were utilized to identify the structural composition of the synthesized N-DPSA. The new N-DPSA was investigated by Hall-effect measurement to prove the positive charge carrier (hole mobility) with mobility and conductivity of 2.39 × 10³ cm²/Vs and 1.76 × 10^-1 1/Ω cm, respectively. Consequently, N-DPSA could be proposed as a strong candidate as a p-type semiconductor (hole transport layer (HTL)). The optical energy gap was computed at 2.03 eV, indicating the direct optical transition nature of N-DPSA. The elaborated molecular semiconductor's thermal features, molecular modelling, and electronic energy levels were also investigated. The new N-DPSA at various concentrations provided easy synthesis, cheap cost, high performance, and a straightforward design approach for a possible HTL in effective perovskite solar cells (PSCs). A PCE of 7.3% is shown for the N-DPSA-based PSC at its optimal concentration.

• Book : 14(1)
• Pub. Date : 2025
• Page : pp.3
• Keyword :

Abstract

Purpose

To harmonize the use of color for MR relaxometry maps and therefore recommend the use of specific color‐maps for representing , , and maps and their inverses.

Methods

Perceptually linearized color‐maps were chosen to have similar color settings as those proposed by Griswold et al. in 2018. A Delphi process, polling the opinion of a panel of 81 experts, was used to generate consensus on the suitability of these maps.

Results

Consensus was reached on the suitability of the logarithm‐processed Lipari color‐map for and the logarithm‐processed Navia color‐map for and . There was consensus on color bars being mandatory and on the use of a specific value indicating “invalidity.” There was no consensus on whether the ranges should be fixed per anatomy.

Conclusion

The authors recommend the use of the logarithm‐processed Lipari color‐map for displaying quantitative maps and maps; likewise, the authors recommend the logarithm‐processed Navia color‐map for displaying , , , and maps.

This work originated with the Quantitative MR Study Group of the International Society of Magnetic Resonance in Medicine (ISMRM); it has the approval of the Publication Committee and of the Board of the ISMRM.

• Book : 93(2)
• Pub. Date : 2025
• Page : pp.490-506
• Keyword :

• Book : 65(1)
• Pub. Date : 2025
• Page : pp.010401
• Keyword :

• Book : 1054()
• Pub. Date : 2025
• Page : pp.122982
• Keyword :