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2025
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- Pub. Date : 2025
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2025
Diagnostic radiology is the most significant contributor to irradiation in the general population. Unnecessary irradiation of workers, patients, and the public during radiological procedures should be significantly reduced without affecting the medical diagnostic value. This study was conducted to analyze and evaluate the radiation dose rate, radiation protection facilities and radiation worker dose of Radiology Installation of Pariaman Regional Hospital. The method of determining the radiation dose rate at the Radiology Instalansi of Pariaman Hospital uses a PDR 303 gamma surveymeter and the rooms to be measured are CT-Scan rooms, conventional X-rays and mammography. Collecting data on radiation protection facilities, then it will be analyzed based on Nuclear Energy Regulatory Agency Regulation No. 4 of 2020 and radiation worker dose data in 2023 will be analyzed based on Nuclear Energy Regulatory Agency Regulation No. 4 of 2013. The results of the study showed that the radiation dose rate around the CT-Scan room was found to be (0.24-1.61) μSv/hour, the conventional X-ray room with irradiation using the minimum exposure factor obtained a radiation dose rate around the room ranging from (0.013-0.33) μSv/hour and with the maximum exposure factor obtained a dose rate around the room of (0.33-1.08) μSv/hour and the mammography room obtained a radiation dose rate of (0.03-0.40) μSv/hour. The radiology room facilities used by Pariaman Hospital are in accordance with the standards set by Nuclear Energy Regulatory Agency Regulation No. 4 of 2020. And the dose rate received by radiation workers at Pariaman Hospital is below the Dose Limit Value set by Nuclear Energy Regulatory Agency Regulation No. 4 of 2013. Based on the results of this study, it is found that there are several measurement points in the CT-Scan and conventional X-ray rooms that exceed the community dose limit value.- Book : 21(3)
- Pub. Date : 2025
- Page : pp.269-269
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2025
In this work, the primary objective was to achieve a complete and detailed structural assignment of the 1H and 13C nuclear magnetic resonance (NMR) data for kaurenoic acid (KA) (ent-kaur-16-en-19-oic acid), a widely studied natural diterpene with various reported biological activities. To facilitate this, the kaurenoic acid methyl ester (ent-methyl-kaur-16-en-19-oate) was also elucidated, leveraging its slight structural differences and the corresponding variations in chemical shifts. The comprehensive assignment was accomplished through the analysis of spectra obtained from each sample, enabling the measurement of all hydrogen homonuclear coupling constants and the clarification of signal multiplicity in the 1H-NMR spectra. Consequently, NMR techniques such as 1H-NMR, 13C{1H}, g-COSY, g-HSQC, g-HMBC, and J-resolved experiments were employed. Additionally, two different software programs, FOMSC3 and NMR_MultiSim, were utilized to simulate 1H-NMR signals, which further assisted in the complete assignment. Furthermore, different deuterated solvents were used to clarify overlapping regions and enrich the dataset.- Book : ()
- Pub. Date : 2025
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2025
Triple-negative breast cancer (TNBC) represents the most aggressive breast cancer subtype, defined by its limited therapeutic options and poor outcomes. This study investigated the therapeutic potential of targeting Na+ homeostasis in TNBC cells to induce TNBC inhibition. For this purpose, BALB/c mice were inoculated with 4T1-Luc2 breast cancer cells and treated with the Na+ ionophore monensin (8 mg/kg) or vehicle alone. Tumor development and cellular Na+ content were assessed using vivo live imaging techniques, while intracellular Na+ variations and cytotoxicity were evaluated through live cell analysis. Monensin treatment increased Na+ levels in cancerous tissues and reduced TNBC mass (monensin: 0.146 ± 0.06; vehicle: 0.468 ± 0.2 cm3; p < 0.001). This treatment induced extensive necrosis in TNBC tumors while preserving the structural and functional integrity of healthy organs and maintaining the proliferative activity of both tumor and normal tissues. Monensin did not alter the expression of proliferating nuclear antigen (PCNA) in 4T1-Luc2 cells but triggered cytotoxicity preceded by intracellular Na+ accumulation. Na+-free conditions prevented both Na+ accumulation and 4T1-Luc2 cell death. Thus, monensin exerts its antitumor effects in TNBC through a Na+-dependent and tumor-specific cytotoxic mechanism, without inducing cytostatic effects on normal or transformed tissues. Collectively, these findings underscore the potential of Na+ ionophores as promising therapeutic agents for TNBC.- Book : 14(3)
- Pub. Date : 2025
- Page : pp.185-185
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2025
The operation of floating nuclear power plants is subject to a number of environmental factors in addition to the typical working temperature and pressure loads. These include marine environmental loads, which can cause fatigue damage and therefore must be taken into account. The fatigue analysis of marine structures frequently employs frequency domain methods, whereas the fatigue analysis of pressure equipment predominantly utilizes time-domain methods. At present, there is no comprehensive and accessible approach for conducting a fatigue analysis of pressure equipment in floating nuclear power plants. In light of the aforementioned considerations, this paper puts forth a novel approach to evaluating fatigue damage based on the principle of damage combination. This article presents a finite element model of pressure equipment and a methodology for calculating the transfer function of such equipment under wave loads. The frequency domain method is employed to calculate the fatigue damage caused by wave loads, with consideration given to both the working temperature and pressure load. The stress time history curve of pressure-bearing equipment is then calculated using the time-domain method. Subsequently, the fatigue damage caused by thermal pressure loads is obtained through a combination of the rainflow counting method and cumulative damage theory, with verification conducted using time-domain calculations. In comparison to alternative damage combination methodologies, the novel approach offers more precise and straightforward damage calculations, with promising potential for integration into engineering design.- Book : 13(2)
- Pub. Date : 2025
- Page : pp.236-236
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2025
- Book : ()
- Pub. Date : 2025
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2025
The aim of this study was to investigate the antioxidant capacity of fruit wines and their protective effects against hydrogen peroxide-induced oxidative stress in rat synaptosomes in vitro. The wines were produced from strawberries and drupe fruits (i.e., plum, sweet cherry, peach, and apricot) through microvinification with a pure S. cerevisiae yeast culture. Fruit wines were produced with and without added sugar before the start of fermentation, whereas subvariants with and without pits were only applied to drupe fruit wines. First, synaptosomes were treated with the wines, while oxidative stress was induced with H2O2. Subsequently, the activities of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx)) and the content of malondialdehyde (MDA), an indicator of membrane injury, were determined. In addition, the Briggs–Rauscher reaction (BR) was used to evaluate the inhibition capacity against free radicals. All investigated fruit wines increased the activity of the studied antioxidant enzymes and decreased MDA content compared to the corresponding controls (synaptosomes treated with H2O2). After synaptosomal treatment with plum wine, the highest activities were observed for SOD (5.57 U/mg protein) and GPx (0.015 U/mg protein). Strawberry wine induced the highest CAT activity (0.047 U/mg protein) and showed the best ability to reduce lipid peroxidation, yielding the lowest MDA level (2.68 nmol/mg). Strawberry, plum, and sweet cherry wines were identified as samples with higher antioxidant activity in both principal component analysis (PCA) and hierarchical cluster analysis (HCA). Finally, plum wine exhibited the highest inhibitory activity in the BR reaction (397 s). The results suggest that fruit wines could be considered potential functional food due to their protective effects against oxidative stress.- Book : 14(2)
- Pub. Date : 2025
- Page : pp.155-155
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2025
The quest for alternatives to traditional cold chain preservation and heat-based shelf-life extension has become increasingly important in recent years. As a result, investigation into the effects of ultraviolet (UV) radiation on the physicochemical properties of various substances, including milk, has gained significant attention. UV-C light, in particular, is recognized for its effectiveness in inactivating a wide range of bacteria and spores in aqueous solutions. This work aims to design a continuous annular UV reactor for milk treatment to examine the impacts on milk’s microbial and physicochemical characteristics and compare these outcomes to those achieved through conventional pasteurization methods. For the same, a 11 W conventional UV-C lamp (254 nm) and an in house designed 17.5 W far UV-C (222 nm) lamp have been used. The key parameters, such as pH, conductivity, temperature, fat/solid not fat, and microbial load, are assessed. The UV dosage supplied to milk samples is determined using actinometry and measured to be 6.16 J/ml. The methylene blue reduction test of milk increases up to more than 5 h, with just four passes through the UV reactor. Approximately 5 log reductions in the Salmonella typhimurium and Staphylococcus aureus have been achieved in just three passes (residence time 24.3 s) of whole milk. The results obtained are compared to those obtained using the pasteurization technique. We found that the proposed UV reactor has an identical performance in inactivating the micro-organisms compared to pasteurization without altering the physico-chemical properties. This suggests the possibility of utilizing UV sources to improve milk’s safety, quality, and shelf life. This study expands the scope of applications for UV-C irradiation as a feasible non-thermal method in the dairy industry.- Book : 15(2)
- Pub. Date : 2025
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2025
- Book : 196()
- Pub. Date : 2025
- Page : pp.109315-109315
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2025
- Book : ()
- Pub. Date : 2025
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