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2025
The transport properties of a nanobridge superconducting quantum interference device made of Al/Pt bilayer have been studied. Measurement and approximation of the voltage‐field dependencies allow to estimate the inductance of the structure. It is found that this value significantly exceeds the expected geometric inductance and exhibits an atypical temperature dependence. To explain this effect, a microscopic model of electron transport in SN bilayers is developed, considering the proximity effect, and the available regimes of the current distribution are described. The measured properties may be indicative of the formation of high‐resistance aluminum with high values of kinetic inductance during the fabrication of Al/Pt bilayers.- Book : ()
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2025
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2025
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2025
- Book : 1012()
- Pub. Date : 2025
- Page : pp.116811-116811
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2025
Background and Objective: Mammea siamensis (MS) is a Thai herb used in traditional medicine. Previous studies have reported the antiproliferative effects of its constituents in various cancer cell lines. However, the effects of MS extract on cytotoxicity and mo-lecular mechanisms of apoptosis induction in HCT116 colon cancer cells have not been fully explored. Methods and Results: The cytotoxic effect of MS extract on HCT116 cells was assessed using the MTT assay. MS extract increased cytotoxicity in a concentra-tion-dependent manner. It also induced nuclear morphological changes and disrupted the mitochondrial membrane potential (ΔΨm), as assessed by Hoechst 33342 and JC-1 staining, respectively. These findings indicated that MS extract induced apoptosis, which was further confirmed by flow cytometry showing an increase in the sub-G1 phase. To investigate the expression of signaling proteins, western blot analysis was conducted. The results showed that MS extract activated caspase activity (caspase-8, -9, and -7) and inhibited PARP activity. Additionally, MS extract upregulated pro-apoptotic proteins (tBid, Bak, and cytochrome c) while downregulating anti-apoptotic proteins (Bcl-2 and Bcl-xL). Mechanistic studies revealed that MS extract activated MAPK pathways while inactivating the PI3K/Akt/NF-κB and GSK-3β/β-catenin pathways. Notably, MS extract also inhibited V-ATPases, as evaluated by acridine orange staining and western blot analysis. Conclusions: Our findings suggest that MS extract induces apoptosis via the activation of both intrinsic and extrinsic pathways associated with the key signaling pathways. Therefore, MS extract shows potential as a therapeutic agent for colon cancer.- Book : ()
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2025
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2025
- Book : 44(2)
- Pub. Date : 2025
- Page : pp.115250-115250
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2025
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- Pub. Date : 2025
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2025
A novel compound, 8-[(E)-(3-hydroxyphenyl)diazenyl]-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione (PAT), was synthesized via the diazotization and coupling reaction of m-amino phenol with theophylline. In addition, complexes of the ligand (PAT) with [Ce (IV) and La (III)] were synthesized. The structural features of the synthesized compounds were examined using several spectroscopic techniques including elemental analyses [CHN], Fourier transform infrared spectroscopy (FTIR), UV-Visible spectroscopy (UV-Vis) and proton nuclear magnetic resonance spectroscopy (1H NMR). Other characterization techniques employed were magnetic measurement, molar conductance data, thermal analysis (thermogravimetric analysis, TGA), inductive coupled plasma (ICP), and scanning electron microscopy (SEM). Through the FTIR study, it was found that the PAT ligand behaves as a neutral N,N- bidentate ligand and that the two complexes have octahedral coordination geometry with six coordination sites. The ligand and its complexes were assessed as antioxidant by DPPH free radical scavenging with ascorbic acid as a positive control for comparative with the synthesized compounds which were appeared good activities, also all compounds were tested for their antibacterial activity via disk diffusion method (MIC) at two concentration (50 mg/ml and 100 mg/mol) they had varying effectiveness compared to amoxicillin as reference- Book : ()
- Pub. Date : 2025
- Page : pp.39-51
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2025
Lung cancer is one of the most common malignancies and causes the most cancer deaths in the United States. Targeted therapies have improved the survival of patients with advanced disease. Neurotrophic tropomyosin receptor kinase (NTRK) fusions are a rare oncogenic driver that has been targeted with the tumor-agnostic drug, larotrectinib. There are limited data on the treatment of non-small-cell lung cancer (NSCLC) with larotrectinib because of the rarity of this fusion in this population. We present the case of a patient who was diagnosed with SQSTM1-NTRK1 fused NSCLC with polymetastatic disease involving the brain and subsequently treated with a multidisciplinary approach via neurosurgical resection, radiotherapy, and larotrectinib. The combination of aggressive local treatments and systemic therapy is a relatively new treatment paradigm and represents a new area of research to optimize local control of metastatic lesions and potentially improve progression-free survival compared to the trials that show the efficacy of systemic monotherapies. The patient has experienced a sustained complete response to treatment almost 3 years later, and he has tolerated the drug without any significant adverse effects. The combination of systemic therapy with larotrectinib and aggressive local treatments could benefit patients with targetable fusions even with multiple metastatic lesions. - Book : 17()
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