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2025
- Book : 18()
- Pub. Date : 2025
- Page : pp.100468-100468
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2025
This research examines the interconnection between energy consumption and economic expansion in Central Africa, utilizing advanced econometric methods to guarantee accurate and dependable outcomes. The findings reveal that energy usage and carbon emissions positively impact economic growth, whereas alternative nuclear energy sources have an adverse effect. In contrast, renewable electricity production and agricultural employment showed no significant impact. Notably, a 1% increase in energy consumption yields a 0.4169% rise in economic growth, and a 1% increase in CO2 emissions results in a 0.0669% growth. Cointegration analysis confirmed a long-term equilibrium relationship among these variables at a 1 % significance level, indicating that all the variables are cointegrated. This study contributes to the ongoing discussion on energy consumption, economic growth, and environmental policies, offering robust evidence of their dynamic interplay. The results align with existing research, providing fresh insights and informing policymakers, researchers, and stakeholders about the intricate relationships between energy use, growth, and environmental sustainability in Central Africa.
- Book : 15(2)
- Pub. Date : 2025
- Page : pp.164-170
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2025
ABSTRACTSeparase is a well conserved endopeptidase that facilitates sister chromatid separation at the metaphase-anaphase transition by cleaving cohesins. Beyond its role in chromosome segregation, Separase also participates in various biological processes, including chromatin organization and replication, centrosome disengagement and duplication, cytokinesis, and telomere capping. Here, we report that the loss ofDrosophilaseparase (Sse) function induces significant changes in global protein expression and affects the protein levels of both A/C-type lamin C (LamC) and B-type lamin Dm0 (Dm0). We further demonstrate that SSE physically interacts with lamins and colocalizes with them at the nuclear envelope during interphase. Additionally, loss of SSE activity disrupts nuclear organization in larval muscles and impairs locomotion in adult flies. Notably, similar to SSE in flies, depletion of human separase (ESPL1) in SV40 fibroblasts leads to misshapen nuclei and increased levels of lamin A. Moreover, we show that ESPL1 interacts with lamin A in human fibroblasts, suggesting that the functional interaction between Separase and lamins is evolutionarily conserved across different organisms.- Book : ()
- Pub. Date : 2025
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2025
AbstractDeveloping robust methods for amplifying and analysing highly-polymorphic nuclear genetic markers from environmental samples could assist in the reliable and scalable long-term monitoring of elusive, threatened or invasive species that are otherwise challenging to observe. In this study, we used zebrafish in controlled aquaria to apply forensic science approaches and demonstrate that microhaplotypes, which are short segments of nuclear DNA (100–300bp) containing two or more single nucleotide polymorphisms (SNPs), can be amplified from trace DNA in water samples to accurately estimate population genetic diversity and species abundance. We successfully amplified a panel of 17 microhaplotypes that comprised 69 SNPs which could reliably estimate population-level allele frequencies and genetic diversity estimates from water DNA. The panel of microhaplotypes amplified from water samples from replicate tanks strongly matched allele frequency estimates from corresponding tissue samples, and could also be used for estimating number of contributors from multi-individual samples. Our research demonstrates the effectiveness and potential of amplifying microhaplotype panels from eDNA as a non-invasive and scalable tool for population genetic studies of aquatic species.- Book : ()
- Pub. Date : 2025
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2025
- Book : ()
- Pub. Date : 2025
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2025
- Book : ()
- Pub. Date : 2025
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2025
- Book : ()
- Pub. Date : 2025
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2025
- Book : ()
- Pub. Date : 2025
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2025
- Book : ()
- Pub. Date : 2025
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2025
Abstract
Introduction Concurrent chemoradiation is the treatment of choice for unresectable locally advanced pancreatic cancer (LAPC). Recent progress toward an effective chemotherapeutic regime has seen improvement in systemic control; however, local control remains a significant issue. One strategy to improve local control and survival is stereotactic body radiotherapy (SBRT).
Objectives This study aims to describe the clinical and treatment characteristics of patients with unresectable LAPC treated with SBRT and to assess the outcome.
Material and Methods This is a retrospective observation study of case series involving patients treated with SBRT from January 2015 to December 2023 with unresectable LAPC. Data were recorded from the electronic medical records of the hospital-based cancer registry, and overall survival was calculated using the Statistical Package for the Social Sciences software.
Result We enrolled four patients in this study. This group consisted of four patients with unresectable LAPC who were treated with the FOLFORINOX (folinic acid, fluorouracil, irinotecan, and oxaliplatin) chemotherapy regime followed by SBRT. For most patients, the radiotherapy dose was 30 to 40 Gy five times per week. These patients exhibited no acute or late toxicity, with 5 to 18 months overall survival.
Conclusion Chemotherapy followed by SBRT is an effective treatment in unresectable LAPC besides chemoradiation.- Book : ()
- Pub. Date : 2025
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