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2025
Abstract
We consider the possibility of indirect detection of dark sector processes by investigating a novel form of interaction between ambient dark matter (DM) and primordial black holes (PBHs). The basic scenario we envisage is that the ambient DM is “dormant”, i.e., it has interactions with the SM, but its potential for an associated SM signal is not realized for various reasons. We argue that the presence of PBHs with active Hawking radiation (independent of any DM considerations) can act as a catalyst in this regard by overcoming the aforementioned bottlenecks. The central point is that PBHs radiate all types of particles, whether in the standard model (SM) or beyond (BSM), which have a mass at or below their Hawking temperature. The emission of such radiation is “democratic” (up to the particle spin), since it is based on a coupling of sorts of gravitational origin. In particular, such shining of (possibly dark sector) particles onto ambient DM can then activate the latter into giving potentially observable SM signals. We illustrate this general mechanism with two specific models. First, we consider asymmetric DM, which is characterized by an absence of ambient anti-DM, and consequently the absence of DM indirect detection signals. In this case, PBHs can “resurrect” such a signal by radiating anti-DM, which then annihilates with ambient DM in order to give SM particles such as photons. In our second example, we consider the PBH emission of dark gauge bosons which can excite ambient DM into a heavier state (which is, again, not ambient otherwise), this heavier state later decays back into DM and photons. Finally, we demonstrate that we can obtain observable signals of these BSM models from asteroid-mass PBHs (Hawking radiating currently with ~
$$ \mathcal{O}\left(\textrm{MeV}\right) $$
O
MeV
temperatures) at gamma-ray experiments such as AMEGO-X.- Book : 2025(2)
- Pub. Date : 2025
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2025
Abstract
A study of EPC-type 3D printer materials has been carried out, which has the potential to become a kidney organ phantom. The parameters studied include material density, CT-Number, electron density, effective atomic number, and radiation dose, as well as to determine the visibility of kidney cancer nodules on variations in CT-Scan exposure voltage. The phantom sample was printed using a 3D printer in the shape of a kidney organ. The CT-Scan exposure voltage is set at 80 kV, 100 kV, and 120 kV. The nodule diameters were 2 mm, 4 mm, 6 mm, 8 mm, and 10 mm. The research showed that the material’s density was 1.05 grams/cm3. The CT-Number of samples at each voltage was obtained respectively 35.28 HU, 38.98 HU, and 50.45 HU. The electron density results at each voltage were obtained: 1.035, 1.039, and 1.050, respectively. The EDG results obtained were 3.25 x 1023 electrons/gram. The EDV results obtained were 3.33 x 1023 electrons/cm3. The effective atomic number results were 3.98. These parameters are by the parameters of the kidney organ so that the EPC material has the potential to become a phantom material for the kidney organ. The practical dose value obtained for each voltage is 2.47 mSv, 3.12 mSv, and 3.12 mSv, which is still below the abdominal CT-Scan value of 5-7 mSv. The results of exposure to kidney cancer nodules showed that for nodule visibility for each voltage variation, nodules measuring 4 mm, 6 mm, 8 mm, and 10 mm were visible, while nodules measuring 2 mm were not visible.- Book : 2945(1)
- Pub. Date : 2025
- Page : pp.012027-012027
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2025
Extraosseous osteosarcoma is a rare tumour that mostly affects males more than females. It accounts for 1.2% of all soft tissue sarcomas. It arises from soft tissues without direct attachment to the skeletal system and produces osteoid, bone, or chondroid material. Extraosseous osteosarcoma usually occurs middle-aged and elderly patients (5th–6th decade of life). Extraosseous osteosarcoma is highly aggressive. Due to rarity of this tumour, few data is available in the literature regarding the causes, symptom, and treatment of the disease hence this case report aims to focus some light on the rarity of this tumour along with its radiological features, presentations, and course of treatment. Here, we are discussing a rare case of extraosseous osteosarcoma of 35-year-old female with no prior history of trauma or radiation exposure.- Book : 12()
- Pub. Date : 2025
- Page : pp.1-4
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2025
Background/Objectives: Radiotherapy is one of the various treatment options for patients with metastatic spinal tumors (MST). However, it is difficult to say that this is definitely an optimal treatment for MST, and there are several patients who need surgical treatment because pain or neurologic deficits occur even after radiotherapy. Therefore, this study aimed to analyze which patients received early operative treatment after radiotherapy. Methods: We included 81 patients who underwent decompression and fusion surgery after radiotherapy for MST. Patients who underwent surgery within 6 months after radiotherapy were classified as the early operation group (group E, n = 47), while surgery cases after 6 months after radiotherapy were assigned to the late operation group (group L, n = 34). Risk factor analysis using multivariate regression analysis for early operative treatment after radiotherapy was performed. Also, we analyzed the period from radiotherapy to surgery according to the Bilsky grade. Results: In multivariate analysis, pathologic fractures and semirigid (thoracic) lesions were more frequent in group E than group L (adjusted odds ratio, 4.282, 10.524; p = 0.001, 0.039). In subgroup analysis, there was a difference in the period from radiotherapy to surgery in Bilsky grades above 2 than Bilsky grade 1 (grade 1, 13.6 ± 11.4 months, grade 2, 6.9 ± 6.8 months, grade 3, 6.6 ± 7.5 months; grade 1 vs. 2, p = 0.049, grade 1 vs. 3, p = 0.047). Conclusions: Although the information in this study may only be limited to patients who underwent surgery, early operative treatment after radiotherapy is highly likely for patients with MST accompanied by a Bilsky grade above 2, pathologic fracture and thoracic lesion. In these patients, surgical treatment could be considered as the primary treatment.- Book : 14(3)
- Pub. Date : 2025
- Page : pp.1032-1032
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2025
Palm oil mill effluent (POME) is a major contributor to industrial oily wastewater in Malaysia, demanding effective treatment solutions. This study explores the potential of esterified kenaf core (EKC) fiber as an oil adsorbent for oil removal from POME, optimized using a full central composite design (CCD) within the response surface methodology (RSM) framework. The optimum conditions achieved 76% oil removal efficiency, with a 1:0.5 ratio of mercerized kenaf core to stearic acid (MKC:SA), 15 wt% of catalyst, and 1 h reflux time during the esterification process. The regression model exhibited strong predictive capability, with a significant quadratic correlation and an R2 value of 0.94. The Fourier transform infrared (FTIR) spectroscopy revealed the existence of ester functional groups characterized by significant hydrophobicity and a decrease in hydroxyl groups, indicating the chemical changes of EKC. Moreover, the scanning electron microscopy (SEM) research demonstrated structural alterations in EKC, including heightened surface roughness, fibrillation, and pore development, which improved oil adhesion relative to raw kenaf core (RKC). These findings indicate that EKC provides an effective, environmentally sustainable solution for managing oil wastewater issues in the palm oil sector, facilitating enhanced ecological sustainability and resource management.- Book : 13(2)
- Pub. Date : 2025
- Page : pp.463-463
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2025
Emery–Dreifuss muscular dystrophy type 1 (EDMD1) is a rare genetic disease caused by mutations in the EMD gene, which encodes the nuclear envelope protein emerin. Despite understanding the genetic basis of the disease, the molecular mechanism underlying muscle and cardiac pathogenesis remains elusive. Progress is restricted by the limited availability of patient-derived samples; therefore, there is an urgent need for human-specific cellular models. In this study, we present the generation and characterization of induced pluripotent stem cell (iPSC) lines derived from EDMD1 patients carrying EMD mutations that lead to truncated or absent emerin, together with iPSCs from healthy donor. The patient-specific iPSCs exhibit stable karyotypes, maintain appropriate morphology, express pluripotency markers, and demonstrate the ability to differentiate into three germ layers. To model EDMD1, these iPSCs were differentiated into myogenic progenitors, myoblasts, and multinucleated myotubes, which represent all stages of myogenesis. Each developmental stage was validated by the presence of stage-specific markers, ensuring the accuracy of the model. We present the first iPSC-based in vitro platform that captures the complexity of EDMD1 pathogenesis during myogenesis. This model can significantly contribute to understanding disease mechanisms and develop the targeted therapeutic strategies for EDMD1.- Book : 26(4)
- Pub. Date : 2025
- Page : pp.1539-1539
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2025
Abstract
Superconducting material enables fusion reactor magnet concepts to operate with current densities that would melt materials with non-zero resistance. The application of superconducting material is considered essential for net-positive power machines. Catastrophic damage can occur when superconductivity is lost and the current generates heat. This scenario is called a quench. Stabilizer material carries the magnet current (typically copper) during a quench and is the focus of this work.

Irradiation-induced defects store energy in the Cu crystalline lattice. The presence of defects reduces thermal conductivity (thermally insulating the superconductor), electrical conductivity (increasing temperature ramp rate during a quench), and specific heat capacity (increasing thermodynamic instability). The release of stored energy in the magnet materials, in combination with the magnet material property changes, has the potential to cause extreme off-normal events in superconducting magnets that worsen with fluence.

Stored energy can be released causing local heating and increasing the risk of a quench. For example, following irradiation at 4.6K and a fluence of 0.45*10^18 n/cm^2, an energy release of 0.023 J/g was measured from Cu when increased in temperature from 10K to 18K, which would have been enough energy to create the same temperature increase spontaneously.

Extrapolations of experimental data are used to estimate when spontaneous heating can occur due to the release of energy stored in irradiation-induced defects. Critical fluence values are estimated between 1.74*10^18 n/cm^2 and 2.85*10^19 n/cm^2 for neutron irradiation of Cu at a temperature of 20K.

In-situ cryogenic calorimetry experiments, operated at high-temperature-ramp rates on irradiated magnet materials, could offer certainty for fusion magnet system designers. Periodic annealing of defects through controlled temperature cycling will be essential in fusion power plants to manage the increasing risk of quench as the superconducting magnets accumulate dose. The ideal frequency and dynamics of these maintenance temperature cycles will be established with further experimental examination. 
- Book : ()
- Pub. Date : 2025
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2025
- Book : 37(2)
- Pub. Date : 2025
- Page : pp.509-509
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2025
Background/Objectives: Many patients evaluated by shoulder specialists suffer from intractable pain, neuropathy, and weakness. The pectoralis minor (PM) remains the only scapula muscle to receive lower trunk (C8-T1) input. We propose a novel, unifying musculoskeletal and neurologic syndrome: the Human Disharmony Loop. This model portrays how this unique PM innervation causes scapular dyskinesia which deranges the anatomy of the upper limb girdle and produces a refractory symptom complex of pain, neuropathy, and weakness. Methods: Ten patients of diverse etiologies presented with a similar constellation of complaints. Patients included: female athlete, female with macromastia, male bodybuilder, post-radiation breast cancer, postoperative shoulder arthroplasty, interscalene block injury, cervical spine disease, persistent impingement after rotator cuff repair, direct traction injury, and occupational disorder. All patients exhibited coracoid tenderness, scapula protraction with internal rotation and anterior tilt, and pain involving the neck, shoulder, and upper back. Patients demonstrated varying degrees of arm neuropathy, subacromial impingement, occipital headaches. Patients failed all prior treatments by multiple subspecialists including surgery. Each patient underwent isolated open PM tenotomy. Results: PM tenotomy completely resolved presenting signs and symptoms in all patients. This included elimination of shoulder, upper back, and neck pain, clearance of concomitant neuropathy, resolution of rotator cuff impingement, restoration of full motion, and eradication of headaches. Response to surgery was rapid, dramatic, and durable. Conclusions: The unique asymmetric neurologic innervation to the sole ventral stabilizer of the scapula, the pectoralis minor, predisposes the human shoulder to neurologic and musculoskeletal imbalance. This produces the Human Disharmony Loop: a clinical syndrome spanning the neck to the fingertips of chronic pain, neuropathy, and weakness. These challenging patients may benefit dramatically from isolated PM tenotomy.- Book : ()
- Pub. Date : 2025
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2025
Abstract
The epidermis is the outermost layer of the skin and acts as the primary barrier to protect the body. Dendritic epidermal T cells (DETCs), which are specifically distributed in epidermal tissues, play a crucial role in skin immune surveillance and wound healing. DETCs are one of the most important components of the epidermis and exert a steady-state monitoring function, facilitating wound healing and tissue regeneration after skin injury. Skin wounds are often linked to other pathological conditions such as ageing, ultraviolet radiation, and metabolic diseases such as diabetes mellitus and obesity. Therefore, it is crucial to investigate how DETCs regulate themselves and the external environment during these pathological states. DETCs interact closely with keratinocytes in the epidermis, and this intercellular interaction may be essential for maintaining health and integrity. In this review, we focus on the characteristics and underlying mechanisms of DETCs in maintaining epidermal homeostasis and re-epithelialization in different pathological states.- Book : 13()
- Pub. Date : 2025
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