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2025
- Book : 128()
- Pub. Date : 2025
- Page : pp.107074-107074
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- Pub. Date : 2025
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AbstractThe Airborne Warning and Control System (AWACS) are pivotal assets in aerial operations, necessitating specialised protection measures, and serving as prime targets for enemy anti‐radiation missiles (ARMs). This paper explores approaches to enhance the battlefield survivability of frequency diverse array AWACS (FDA‐AWACS) by incorporating airborne radar technology onto the platform. The study commences by analysing the typical operational methods of anti‐radiation missiles. Following this, a deception model is formulated for the frequency diverse array (FDA) against the passive radar homing head of anti‐radiation missiles utilising the adjacent antenna single‐pulse amplitude‐comparison direction‐finding technique. Expanding on this groundwork, the research further assesses the deceptive impacts of FDA‐AWACS on direction finding cross‐location techniques. Simulation results validate that FDA‐AWACS can effectively counter the threat of anti‐radiation missiles by diminishing their direction‐finding and positioning systems.- Book : 19(1)
- Pub. Date : 2025
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- Pub. Date : 2025
- Page : pp.1-16
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Introduction. Previous studies identified genetic links between the TCF7L2 C/T variant rs7903146, type 2 diabetes (T2D), and obesity. We wished to deepen our understanding of how specific diets interact with this variant to affect blood metabolites, an aspect not previously investigated. Hence, we conducted a controlled study where individuals with different genotypes followed a Mediterranean (Med) or low-fat (LF) diet for one week.
Methods. Participants were recruited from the Boston, MA (USA) area. Anthropometric and clinical measures were taken. Genotypes at rs7903146 were ascertained, with homozygous carriers of the more common and protective CC or risk TT genotype invited to participate. Participants followed both diets (LF or Med) for one week with ~10 days’ washout between diets. Blood samples taken at the beginning and end of each diet period underwent metabolomics analysis using nuclear magnetic resonance spectroscopy. We evaluated how the diet affected different metabolites based on genetic profile.
Results. The cohort of 35 persons was 43% female, aged 18 to 70 y, with BMI between 26.4 to 33.9 kg/m2. Focusing on fatty acids (FAs) and other lipid metabolic factors (n = 23), we observed a greater number and stronger correlations among these factors in the CC genotype-Med diet group than the other three genotype-diet combinations. An aggregate of 11 factors, each negatively correlating with delta saturated fatty acids (SFA), showed a significant genotype-Med diet interaction on delta-SFA in CC individuals on the Med diet (p = 0.0046). A similar genotype-Med diet interaction was observed for delta-monounsaturated fatty acids (MUFA) (p = 0.0078). These interactions were not statistically significant at the end of the LF intervention.
Conclusion. Our findings suggest that the Mediterranean diet has stronger influence on regulating lipid factors in individuals with the CC genotype at TCF7L2 variant rs7903146. This diet-genotype interaction may have significant implications for understanding the inter-individual variation of metabolic response on specific dietary regimens.- Book : ()
- Pub. Date : 2025
- Page : pp.1-24
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Background: Traditional freehand techniques in high tibial osteotomy (HTO) have been shown to lack precision and accuracy. Patient-specific instrumentation (PSI) and fixation created from cross-sectional imaging have recently been introduced to address this problem. Purpose/Hypothesis: The purpose of the study was to compare traditional freehand techniques versus PSI in a human cadaveric model of HTO. It was hypothesized that the osteotomies performed using PSI would require less radiation exposure for operating room staff and would reduce deviation from the planned correction in the coronal, sagittal, and axial planes. Study Design: Controlled laboratory study. Methods: Sixteen matched cadaveric knees underwent medial opening-wedge HTO via the freehand method (n = 8) or PSI technique (n = 8) with a predetermined planned opening-wedge size. Computed tomography was used to measure the achieved wedge size as well as alignment parameters in the coronal, sagittal, and axial planes. Radiation dose, number of fluoroscopic images taken, and total operative time were recorded. Results: The mean deviation from the planned wedge size was smaller in the PSI group compared with the freehand group (0.505 vs 3.016 mm, respectively; P < .01). Total radiation dose to medical staff (0.85 vs 2.04 mGy; P < .01) and number of fluoroscopic images (15.5 vs 41; P < .01) were also smaller in the PSI versus the freehand group, respectively. No difference was seen in total operative time between the 2 groups ( P = .62). Conclusion: In cadaveric specimens, the PSI technique demonstrated superior accuracy and decreased radiation exposure for medical staff compared with the traditional freehand technique without compromising operative efficiency. Clinical Relevance: The use of PSI when HTO is performed can lead to more accurate operations and potentially improve outcomes. - Book : 13(1)
- Pub. Date : 2025
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