• Book : 13(01)
• Pub. Date : 2025
• Page : pp.163-172
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Conventional circularly polarized antennas have been employed to deliver microwave illumination in microwave-induced thermoacoustic tomography (TAT). However, these antennas exhibit several limitations in TAT systems, including low efficiency, poor axial ratio (AR) roundness, and narrow axial ratio beamwidth (ARBW). These issues lead to uniform radiation only within a relatively confined area, thereby restricting their effectiveness in clinical applications such as breast imaging. To address these issues, we propose a novel planar slot array antenna that offers a wide ARBW and improved axial ratio (AR) roundness, enabling homogeneous illumination over a larger field. We validated this approach both theoretically and experimentally. Tissue-mimicking phantoms were imaged, demonstrating that the antenna generated a circularly polarized electric field as well as a uniformly illuminated area. These advantages make the antenna proposed in this paper more suitable for clinical imaging compared to traditional microwave radiating antennas.

• Book : 17(2)
• Pub. Date : 2025
• Page : pp.197-197
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The purpose of this study was to extract the lipophilic fraction from one of the largest source of waste in the industrial sector, namely, the tomato residue from processing the fruit. In order to make this process more environmentally sustainable, this study used a green extraction protocol employing natural deep eutectic solvents (NADESs) combined with a less energy-consuming technology, the ultrasound-assisted extraction (UAE) method, to simultaneously recover carotenoids and tocopherol from dried powder tomato waste. Two NADESs, one hydrophilic and one hydrophobic, were prepared and compared to support high extraction efficiency and increase the stability of the extracted compounds. The optimal extraction parameters were identified as choline chloride:1,3-butanediol (1:5)-based NADES, a solid-to-liquid ratio of 1:20 (w/v), time of extraction 12 min, temperature 65 °C, radiation frequency 37 Hz, and an ultrasound power level of 70%. The extraction process was intensified and resulted in extracts rich in lycopene (215.13 ± 4.31 μg/g DW), β-carotene (206.95 ± 3.27 μg/g DW), and tocopherol (130.86 ± 8.97 μg/g DW) content, with the highest antioxidant capacity 93.84 ± 0.18 mM Trolox equivalent. Incorporating NADESs for the extraction of bioactive compounds offers numerous benefits, such as improved sustainability, enhanced extraction efficiency, better protection of sensitive compounds, and reduced environmental impact. These advantages make NADESs a promising alternative to traditional organic solvents, especially in industries that require natural, green, and efficient extraction processes for valuable bioactive molecules.

• Book : 30(3)
• Pub. Date : 2025
• Page : pp.591-591
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• Pub. Date : 2025
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Abstract Background Radiotherapy as a complement or an alternative to neurosurgery has a central role in the treatment of skull base grade I-II meningiomas. Radiotherapy techniques have improved considerably over the last two decades, becoming more effective and sparing more and more the healthy tissue surrounding the tumour. Currently, hypo-fractionated stereotactic radiotherapy (SRT) for small tumours and normo-fractionated intensity-modulated radiotherapy (IMRT) or proton-therapy (PT) for larger tumours are the most widely used techniques. It is expected a decrease of the risk of cognitive impairment with these modern techniques. However prospective data about cognitive long-term consequences of partial brain irradiation with SRT, PT, or IMRT remain very scarce to date. Methods CANCER COG is one of the first multicentric study in the world to prospectively assess the cognitive performances of patients following different modalities of cerebral radiotherapy (stereotactic radiotherapy, proton therapy, intensity modulated radiotherapy) for the treatment of grade I-II skull base meningioma, up to at least 10 years after the end of radiotherapy. This longitudinal study includes the follow-up of 3 cohorts, including: patients treated with PRT, IMRT, and SRT. An additionally control group will be formed. The primary objective is to report long-term cognitive deterioration in each cohort until 10 years after the end of irradiation. The rate of clinical symptomatology improvement over time after irradiation, the evolution of health-related quality-of-life, anxiety/depression, fatigue, over time after irradiation, the tumoral local control after irradiation, the progression-free survival (PFS), the professional reintegration for working-age patients will also be assessed. CANCER COG aims to help clinicians to choose the best irradiation techniques with the best benefit/risk ratio. Inclusions started on september 2023. Trial registration The study was registered on clinicaltrials.gov with the following number: NCT 06036706.

• Book : 20(1)
• Pub. Date : 2025
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• Pub. Date : 2025
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